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Growth Stimulation and Immunoglobulin (Ig) Secretion in Epstein-Barr Virus (Ebv)-Infected B Cells by Interleukin 6 (IL-6)

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Epstein-Barr Virus and Human Disease • 1988

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 20))

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Abstract

Human resting B lymphocytes infected by EBV proliferate, produce immunoglobulin and become immortalized (1). The mechanisms of B cell activation by EBV are largely unknown. Recently, attention has been focused on the observation that growth of EBV-immortalized B lymphocytes is dependent, at least in part, upon the availability of growth factors produced either by the same EBV-immortalized cells (autocrine growth factors) (2, 3) or by activated monocytes (paracrine growth factors) (4, 5). This has raised the possibility that maintenance of an immortalized state by EBV might require the establishment of an autocrine loop, and/or the expression of appropriate growth factor receptors (6).

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References

  1. G. Tosato, Adv. Cancer Res. 49, 75 (1987).

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  6. B. Sudgen, J. Yates, and W. Mark, J. Invest. Dermatol. 83, 825 (1984).

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Author information

Authors and Affiliations

  1. Center for Biologies Evaluation and Research, FDA, Bethesda, MD, 20892, USA

    Giovanna Tosato & Sandra E. Pike

Authors
  1. Giovanna Tosato
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  2. Sandra E. Pike
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Editor information

Editors and Affiliations

  1. National Cancer Institute, Bethesda, Maryland, USA

    Dharam V. Ablashi

  2. Universitá “La Sapienza,”, Roma, Italy

    Alberto Faggioni

  3. University of Cologne, Cologne, West Germany

    Gerhard R. F. Krueger

  4. University of North Carolina, Chapel Hill, North Carolina, USA

    Joseph S. Pagano

  5. Georgetown University Medical School, Washington, DC, USA

    Gary R. Pearson

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© 1989 The Humana Press Inc.

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Tosato, G., Pike, S.E. (1989). Growth Stimulation and Immunoglobulin (Ig) Secretion in Epstein-Barr Virus (Ebv)-Infected B Cells by Interleukin 6 (IL-6). In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_34

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  • DOI: https://doi.org/10.1007/978-1-4612-4508-7_34

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8852-7

  • Online ISBN: 978-1-4612-4508-7

  • eBook Packages: Springer Book Archive

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