Abstract
B cells latently infected with Epstein-Barr virus(EBV) express at least 5 nuclear antigens (EBNA) (1, 2) and a membrane protein (IMP) (3). The EBNA-1 molecule has a large glycine-alanine repeat, which carries the major epitope(s) for IgM anti-EBNA-1 antibodies that develop during infectious mononucleosis (IM) (4). The repeat is also the major epitope for IgG antibodies that occur post EBV infection (4). Some autoimmune sera have elevated IgG levels to EBNA-1; these antibodies are in part directed to the glycine-alanine repeating sequence (5). However, the prevalence of antibodies to possible epitope(s) located outside the glycine-alanine region is not known.
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© 1989 The Humana Press Inc.
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Petersen, J., Rhodes, G., Roudier, J., Carson, D.A., Vaughan, J.H. (1989). The Immune Response to Glycine-Rich Sequences of Epstein-Barr Nuclear Antigen-1 (EBNA-1) in Autoimmunity: B and T Cell Epitopes. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_30
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DOI: https://doi.org/10.1007/978-1-4612-4508-7_30
Publisher Name: Humana Press
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