Summary
Seropositive donors were screened in the regression assay using the two defined types of EBV. Most donors yielded a similar T cell response to A- and B-types. However two A-type seropositive donors were recognised who showed little, if any regression with B-type virus in spite of a strong A-type response. Similarly two B-type donors showed little if any regression with A-type virus. An analysis of T cell clones generated from lymphocytes stimulated by A- and B-type autologous transformants generally supported the above data and confirmed the existence of seropositive donors whose T cell response is restricted to one strain of EBV. This result is important in the development of a vaccine strategy for EBV.
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References
Moss, D.J., Misko, I.S., Burrows, S.R., Burman, K., McCarthy, R and Sculley, T.B. Cytotoxic T-cell clones distinguish between A- and B-Type Epstein-Barr virus transformants. Nature, 311, 719–721 (1988).
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Sculley, T.B., Appoloni, A., Moss, D.J., Mueller-Lantczh, N., Misko, I.s. and Cooper, D.A. Expression of Epstein-Barr virus nuclear antigens 3, 4 and 6 are altered in cell lines containing B-type virus (submitted).
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© 1989 The Humana Press Inc.
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Moss, D.J., Misko, I.S., Burrows, S.R., Burman, K., McCarthy, R., Sculley, T.B. (1989). An Analysis of the Cytotoxic T-Cell Response of A- and B-Type EB Virus. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_29
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DOI: https://doi.org/10.1007/978-1-4612-4508-7_29
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