Abstract
Epstein-Barr Virus immortalized B lymphocytes axe subject to autocrine stimulation because of, their capacity to produce endogenous factors which stimulate growth. This study questions whether B lymphocytes producing growth factor can also affect proliferation of T lymphocytes. The helper. T cell line, D10.G4.1, is exquisitely sensitive to immunomodulating factors (IL-1 and IL-2) and requires exogenously supplied IL-1 to proliferate in response to ConA. D10.G4.1 cells are stimulated by released soluble factors from virally stimulated B lymphocyte. Para-fornaldehyde-fixed EBV-carrying lymphoblastoid cells also are potent stimulators of ConA treated D10.G4.1 cells in blastogenesis assays. In acute EBV infection T lymphocyte proliferation may be stimulated by released soluble factors from virally infected B lymphocytes. Leukocytosis of T lymphocytes also may result from direct paracrine stimulation by virus carrying B lymphocytes.
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References
Blazar, B.A., Sutton, L.M. and Strom, M. Cancer Res. 43:4562 (1983).
Gordon, J., Ley, S.C.I, Melamed, N.D., Aman, P. and Hughes Jones, N.C. J. Exp. Med. 159:1554 (1984).
Scala, G.I, Kuang, Y., Hall, P.E., Muchmore, A.V., and Oppenheim, J.J. J. Exp. Med. 159:1637 (1984).
Blazar, B.A., Sutton, L.M. and Strom, M. Cancer Immunol. Immunother. 22:62 (1986).
Rimsky, L., Wakasugi, H., Ferrara, P., Robin, P., Capdevielle, J.I, Turz, T., Fradelizi, D. and Bertoglio, J. J. Immunol. 136:3304 (1986).
Ambrus, J.L., Jr. and Fauci, A.S. J. Clin. Invest. 75:732 (1985).
Gordon, J., Ley, S.C., Melamed, M.D., English L.S., Hughes-Jones, N.C. Nature 310:145 (1984).
Blazar, B.A., Rodrick, N.L., Sutton, L.M. and Strom, M. Manuscript submitted.
Kaye, J.I, Porcelli, S., Tite, J.I, Jones, B. and Janeway, C.A., Jr. J. Exp. Med. 158:836 (1983).
Abbas, A.K. Immunology Today 9:89 (1988).
Kurt-Jones, E.A., Beller, D.I., Mizel, S.B., Unanue, E. PNAS 82:1804 (1985).
Niederman, J. In: Infectious Diseases Ed. Paul Hoeprick 3rd edition, Harper & Row, Phil. pp. 1205 (1983).
Schooley, R.T., and Dolin, R. In: Principle and practice of Infectious Disease, Eds. Mandel, G., Douglas, R.G., Bennett, 2nd edition, Wiley, New York (1985).
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Blazar, B.A., Sereno, P., Stevenson, L., Murphy, A.M. (1989). Helper T Lymphocyte Proliferation is Stimulated by the Presence of EBV-Carrying B Lymphocytes. In: Ablashi, D.V., Faggioni, A., Krueger, G.R.F., Pagano, J.S., Pearson, G.R. (eds) Epstein-Barr Virus and Human Disease • 1988. Experimental Biology and Medicine, vol 20. Humana Press. https://doi.org/10.1007/978-1-4612-4508-7_27
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DOI: https://doi.org/10.1007/978-1-4612-4508-7_27
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