Characterization of the EBV Alkaline Exonuclease Expressed in a Recombinant Prokaryotic System
Epstein-Barr virus (EBV) is a human herpesvirus which is the cause of infectious mononucleosis and is associated with two malignancies, Burkitt’s lymphoma and nasopharyngeal carcinoma (NPC). One of the major constraints on studying EBV is the lack of a fully permissive tissue culture system, which has limited both the quality and quantity of EBV proteins available for analysis. However, despite this limitation the EBV genome has been shown to encode a number of open reading frames (orfs), the protein products of which are likely to be involved in DNA replication and metabolism. These proteins include a DNA polymerase; a major DNA binding protein; a ribonucleotide reductase; a thymidine kinase; a dUTPase and an alkaline DNase (1,6,9,10).
KeywordsZinc Magnesium Lymphoma Manganese Radium
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