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Encephalopathy of Reye’s Syndrome: Studies of the Pathogenic Process in Animal Models

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Hepatic Encephalopathy

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 22))

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Abstract

Reye’s Syndrome (RS) is a frequently fatal disease that occurs in children as a rare sequelae to a relatively benign viral illness such as influenza or varicella (1). Its hallmark features include fatty infiltration, particularly of the liver, mitochondrial degeneration, and severe cerebral encephalopathy. The latter is the usual cause of death. The sequence of events that occurs during the early stages of RS are not known; however, this information is of great importance, since unlike true viral encephalopathies, tissue destruction in this disease can be minimal and reversible, and the disease can be recoverable (2). If appreciable brain edema does develop, however, approximately 20% of the patients sustain residual CNS damage.

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Author information

Authors and Affiliations

  1. Depts. of Pharmacology and Pediatrics, Dalhousie University and the Izaak Walton Killam Hospital for Children, Halifax, Nova Scotia, B3H 4H7, Canada

    M. G. Murphy, S. C. Digout & J. F. S. Crocker

Authors
  1. M. G. Murphy
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  2. S. C. Digout
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  3. J. F. S. Crocker
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Editor information

Editors and Affiliations

  1. Laboratory of Neurochemistry, André-Viallet Clinical Research Centre, Hôpital St-Luc (University of Montreal), Montreal, Quebec, Canada

    Roger F. Butterworth PhD

  2. Hepatology Unit, André-Viallet Clinical Research Centre, Hôpital St-Luc (University of Montreal), Montreal, Quebec, Canada

    Gilles Pomier Layrargues MD

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© 1989 The Humana Press Inc.

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Murphy, M.G., Digout, S.C., Crocker, J.F.S. (1989). Encephalopathy of Reye’s Syndrome: Studies of the Pathogenic Process in Animal Models. In: Butterworth, R.F., Layrargues, G.P. (eds) Hepatic Encephalopathy. Experimental Biology and Medicine, vol 22. Humana Press. https://doi.org/10.1007/978-1-4612-4506-3_17

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  • DOI: https://doi.org/10.1007/978-1-4612-4506-3_17

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8851-0

  • Online ISBN: 978-1-4612-4506-3

  • eBook Packages: Springer Book Archive

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