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Adenosine Release

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Adenosine and Adenosine Receptors

Part of the book series: The Receptors ((REC))

Abstract

In contrast to the progress towards consensus regarding the sites and mechanisms of adenosine actions (Williams and Jacobson, 1990; Trivedi et al., 1990), the sites and mechanisms of adenosine formation and subsequent release are still the subjects of heated controversy. However, taken together with the demonstration of specific receptors for adenosine, the study of purine formation and release from tissues has contributed to at least two important hypotheses of tissue control and metabolic regulation. One is the purinergic nerve hypothesis (Burnstock, 1972, 1981), and the second is that adenosine might be an autonomous signal of cellular energy status (Berne, 1964; Lowenstein et al., 1983; Newby, 1984). In this chapter, the stimuli that give rise to adenosine release from various tissues will be reviewed in relation to the specific cell types involved. The biochemical mechanisms available for the formation of adenosine will then be discussed with emphasis given to the possibility of formation from both cytoplasmic and released nucleotides. Finally, some conclusions will be drawn as to the mechanisms of adenosine formation and release, and their physiological significance.

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Authors
  1. Trevor W. Stone
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  2. Andrew C. Newby
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  3. Hilary G. E. Lloyd
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Editors and Affiliations

  1. Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois, USA

    Michael Williams

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© 1990 The Humana Press Inc.

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Stone, T.W., Newby, A.C., Lloyd, H.G.E. (1990). Adenosine Release. In: Williams, M. (eds) Adenosine and Adenosine Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4504-9_6

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  • DOI: https://doi.org/10.1007/978-1-4612-4504-9_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8850-3

  • Online ISBN: 978-1-4612-4504-9

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