Abstract
Adenosine is a purine nucleoside, derived predominantly from the cleavage of 5’adenosine monophosphate (AMP) by 5’nucleotidase (Arch and Newsholme, 1978). The nucleoside subserves both intraand extracellular functions, the latter being effected through specific purine receptors. Two types of extracellular purine receptors have been described: A1 and A2, which can, respectively, inhibit and stimulate adenylate cyclase, modifying intracellular levels of the second messenger cyclic 3’,5’-adenosine monophosphate (Londos and Wolff, 1977; Londos, et al., 1980). More recently, however, these receptors have been defined in terms of their agonist pharmacology (Hamprecht and Van Calker, 1985).
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References
Acker, H. and Starlinger, H. (1984) Adenosine triphosphate content in the cat carotid body under different arterial O2 and CO2 conditions. Neurosci. Leu. 50, 175–179.
Adams, G. K., III and Lichtenstein, L. (1979) In vitro studies of antigen-induced bronchospasm: Effect of anti-histamine and SRB-A antagonist on response of sensitized guinea pig and human airways to antigen. J. Immunol. 122, 555–562.
Altounyan, R. E. C., Lee, T. B., Rocchiccioli, K. M. S., and Shaw, C. L. (1986) A comparison of the inhibitory effects of nedocromil sodium and sodium cromoglycate on adenosine monophosphate-induced bronhoconstriction in atopic subjects. Eur. J. Respir. Dis. (Suppl.147), 69, 277–279.
Anichkov, S. V. and Belen’kii, M. L. (1963) Pharmacology of the carotid body chemoreceptors. ( Pergamon, Oxford).
Aranda, J. V. and Turmen, T. (1979) Methylxanthines in apnoea of prematurity. Clin. Perinatol. 6, 87–108.
Arch, J. R. S. and Newsholme, E. A. (1978) The control of the metabolism and the hormonal role of adenosine. Essays Biochem. 14, 82–123.
Bellardinelli, L., Shryock, J., West, G. A., Clemo, H. F., DiMarco, J. P., and Berne, R. M. (1984) Effects of adenosine and adenine nucleotides on the atrioventricular node of isolated guinea pig hearts. Circulation 70, 1083–1091.
Benyon, R. C., Church, M. K., and Holgate, S. T. (1984) The effect of methyl-transferase inhibitors on histamine release from human dispersed lung mast cells activated with anti-human IgE and calcium ionophore A23187. Biochem. Pharmacol. 33, 2881–2886.
Berne, R. M. (1980) The role of adenosine in the regulation of coronary blood flow. Circ. Res. 47, 807–813.
Berne, R. M., Rubio, R., and Curnish, R. R. (1974) Release of adenosine from the ischaemic brain: Effect on cerebral vascular resistance and incorporation into cerebral adenine nucleotides. Circ. Res. 35, 262–271.
Berne, R. M., Rubio, R., Dobson, J. G., Jr., and Curnish, R. R. (1971) Adenosine and adenine nucleotides as possible mediators of cardiac and skeletal muscle blood flow regulation. Circ. Res. 28, Suppl. 1, 115–119.
Biaggioni, I., Olafsson, B., Robertson, R., Hollister, A. S., and Robertson, D. (1986a) Failure of aminophylline to antagonize the haemodynamic and respiratory effects of adenosine boluses. Pflugers Arch. 407, Suppl. 1, S54.
Biaggioni, I., Olafsson, B., Robertson, R., Hollister, A. S., and Robertson, D. (1986b) Characteristics of adenosine-induced stimulation of respiration in man. Pflugers Arch. 407, Suppl. 1, S55.
Biaggioni, I., Olafsson, B., Robertson, R. M., Hollister, A. S., and Robertson, D. (1987) Cardiovascular and respiratory effects of adenosine in conscious man. Evidence for chemoreceptor activation. Circ. Res. 61, 779–786.
Biscoe, T. J., Bradley, G. W., and Purves, M. J. (1970) The relation between carotid body chemoreceptor discharge, carotid sinus pressure and carotid body venous flow. J. Physiol. 208, 99–120.
Bockuran, E. L., Berne, R. M., and Rubio, R. (1975) Release of adenosine and lack of release of ATP from contracting skeletal muscle. Pflugers Arch. 355, 229–241.
Brown, C. M. and Collis, M. G. (1982) Evidence for an A2/R. adenosine receptor in guinea-pig trachea. Br. J. Pharmacol. 76, 381–387.
Bruce, E. N. and Cherniack, N. S. (1987) Central chemoreceptors. J. Appl. Physiol. 62, 389–402.
Bureau, M. A. and Begin, R. (1982) Postnatal maturation of the respiratory response to 02 in awake newborn lambs. J. Appl. Physiol. 52, 428–433.
Burr, D. and Sinclair, J. D. (1988) The effect of adenosine on respiratory chemosensitivity in the awake rat. Respir. Physiol. 72, 47–57.
Buss, D. C., Routledge, P. A., and Watt, A. H. (1986) Respiratory effects of intravenous adenosine in anaesthetised rabbits before and after carotid nerve section. Br. J. Pharmacol. 88, 413 p.
Butcher, R. W. and Sutherland, E. W. (1962) Adenosine 3’,5’-phosphate in biological materials. J. Biol. Chem. 237, 1244–1250.
Chan-Yeung, M. (1977) The effect of SCH 1000 and disodium cromoglycate on exercise-induced asthma. Chest 71, 320–323.
Church, M. K., Holgate, S. T., and Hughes, P. J. (1983) Adenosine inhibits and potentiates IgE-dependent histamine release from human basophils from an A2-receptor mediated mechanism. Br. J. Pharmacol. 80, 719–726.
Church, M. K., Benyon, R. C., Hughes, P. J., Cushley, M. J., Mann, J. S., and Holgate, S. T. (1985) Adenosine as a putative mediator in asthma: Its role in bronchoconstriction and modulation of histamine release from human lung mast cells and basophil leukocytes, in Purines: Pharmacology and Physiological Roles ( Stone, T. W., ed.), Macmillan, London, pp. 175–184.
Coburn, R. F. and Tomita, T. (1973) Evidence for non-adrenergic inhibitory nerves in guinea-pig trachealis muscle. Am. J. Physiol. 224, 1072–1080.
Cotes, J. E. (1979) Control of respiration, in Lung Function Assessment and Application in Medicine, 4th Ed. ( Cotes, J. E., ed.) Blackwell, Oxford, pp. 251–264.
Crimi, N., Palermo, F., Ciccarello, C., Oliven, R., Vancheri, C., Palermo, B., and Mistretta, A. (1989) Effect of theophylline on adenosine-induced bronchoconstriction. Ann. Allergy. 62, 123–127.
Crimi, N., Palermo, F., Vancheri, C., Oliven, R., Distefano, S. M., Polosa, R., and Mistretta, A. (1988) Effect of sodium cromoglycate and nifedipine on adenosine-induced bronchoconstriction. Respiration 53, 74–80.
Cross, K. W. and Oppe, T. E. (1952) Effect of inhalation of high and low concentration of oxygen on the respiration of the premature infant. J. Physiol. 117, 38–55.
Cushley, M. J. and Holgate, S. T. (1985) Adenosine-induced bronchoconstriction in asthma: Role of mast cell-mediator release. J. Allergy Clin. Immunol. 75, 272–278.
Cushley, M. J., Tallant, N., and Holgate, S. T. (1985) The effect of dipyridamole on histamine-and adenosine-induced bronchoconstriction in normal and asthmatic subjects. Eur. J. Respir. Dis. 67, 185–192.
Cushley, M. J., Tattersfield, A. E., and Holgate, S. T. (1983) Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br. J. Clin. Pharmacol. 15, 161–165.
Cushley, M. J., Tattersfield, A. E., and Holgate, S. T. (1984) Adenosine-induced bronchoconstriction in asthma: Antagonism by inhaled theophylline. Am. Rev. Respir. Dis. 129, 380–384.
Dahlen, S.-E., Hansson, G., Heqvist, P., Bjorck, T., and Ganstrom, E. (1983) Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4,134, and E4. Proc. Natl. Acad. Sci. USA 80, 1712–1716.
Daly, J. W. (1982) Adenosine receptors: Targets for future drugs. J. Med. Chem. 25, 197–207.
Darnall, R. A. (1982) Theophylline reduces ventilatory depression in hypoxic newborn piglets. Pediatr. Res. 16, 347A.
Darnall, R. A. (1983) The effect of opioid and adenosine antagonists on hypoxic ventilatory depression in the newborn piglet. Pediatr. Res. 17, 374A.
Davi, M. J., Sankaran, K., Simons, K. J., Simons, F. E. R., Seshia, M. M., and Rigatto, H. (1978) Physiologic changes induced by theophylline in the treatment of apnoea in preterm infants. J. Pediatr. 92, 91–95.
Davis, C., Kannan, M. S., Jones, T. R., and Daniel, E. E. (1982) Control of human airway smooth muscle: In vitro studies. J. Appl. Physiol. 53, 1080–1087.
Dazsun, Z., Rafferty,P.,Richards, R., Summerell, S., and Holgate, S. T. (1989) Airways refractoriness to adenosine 5’-monophosphate after repeated inhalation. J. Allergy Clin. Immunol. 83, 152–158.
DeBoeck, C., Van Reempts, P., Rigatto, H., and Chernick, V. (1983) Endorphins and the ventilatory depression during hypoxia in newborn infants. Pediatr. Res. 17, 374A.
Dobson, G., Rubio, R., and Berne, R. M. (1971) Role of adenine nucleotides, adenosine and inorganic phosphate in the regulation of skeletal muscle blood flow. Circ. Res. 29, 375–384.
Dowell, A. R., Heyman, A., Sieker, H. O., and Tripathy, K. (1965) Effect of aminophylline on respiratory-center sensitivity in Cheyne-Stokes respiratory and in pulmonary emphysema. New Eng. J. Med. 273, 1447–1453.
Drury, A. N. and Szent-Györgyi, A. (1929) The physiological action of adenosine compounds with special reference to their action upon mammalian heart. J. Physiol. 68, 213–237.
Eiser, N. M. and Guz, A. (1982) Effect of atropine on experimentally-induced airway obstruction in man. Bull. Eur. Physiopathol. Respir. 18, 449–460.
Eldridge, F. L., Millhom, D. E., and Kiley, J. P. (1984) Respiratory effects of a longacting analog of adenosine. Brain Res. 301, 273–280.
Eldridge, F. L., Millhom, D. E., and Kiley, J. P. (1985) Antagonism by theophylline respiratory inhibition induced by adenosine. J. Appl. Physiol. 59, 1428–1433.
Eldridge, F. L., Millhom, D. E., Waldrop, T. G., and Kiley, J. P. (1983) Mechanism of respiratory effects of methylxanthines. Respir. Physiol. 53, 239–261.
Ellwood, R. K., Belzberg, A., Hogg, J. C., and Pare, P. D. (1982) Bronchial mucosal permeability in asthma. Am. Rev. Respir. Dis. 125, Suppl. 63.
Eyzaguirre, C. and Zapata, P. (1984) Perspectives in carotid body research. J. Appl. Physiol. 57, 931–957.
Fagenholz, S. A., O’Connell, K., and Shannon, D. C. (1976) Chemoreceptor function and sleep state in apnoea. Pediatrics 58, 31–36.
Finney, M. J. B., Karlsson, J.-A., and Persson, C. G. A. (1985) Effects of bronchoconstrictors and bronchodilators on a novel human small airway preparation. Br. J. Pharmacol. 85, 29–36.
Fish, J. E., Lenfant, C., and Newball, H. H. (1983) In vivo immunopharmacology of the lung, in Immunopharmacology of the Lung, vol 19 of Lung Biology in Health and Disease ( Newball, H. H., ed.), Marcel Dekker, New York, pp. 273–346.
Fredholm, B. B. (1981) Release of adenosine from rat lung by antigen and compound 48/80. Acta. Physiol. Scand. 111, 507–508.
Fredholm, B. B. (1982) Adenosine receptors. Med. Biol. 60, 289–293.
Fredholm, B. B., Brodn, K., and Strandberg, K. (1979) On the mechanism of relaxation of tracheal muscle by theophylline and other cyclic nucleotide phosphodiesterase inhibitors. Acta. Pharmacol. Toxicol. 45, 336–344.
Fuchs, B. D., Gorman, M. W., and Sparks, H. V. (1986) Adenosine release into venous plasma during free flow exercise. Proc. Soc. Exp. Biol. Med. 181, 364–370.
Fuller, R. W., Maxwell, D. L., Conradson, T.-B. G., Dixon, C. M. S., and Barnes, P. J. (1987) Circulatory and respiratory effects of infused adenosine in conscious man. Br. J. Clin. Pharmacol. 24, 309–317.
Gaba, S., Trigui, F., Dujols, P., Godard, P., Michel, F. B., and Prefaut, C. (1986) Compared effects of ATP vs adenosine on pulmonary circulation of COPD. Eur. J. Respir. Dis. (Suppl. 146), 69, 515–522.
Gottlieb, J. E., Peake, M. D., and Sylvester, J. T. (1984) Adenosine and hypoxic pulmonary vasodilatation. Am. J. Physiol. 247, H541 - H547.
Gottlieb, J. E., Peake, M. D., and Sylvester, J. T. (1984) Adenosine and hypoxic pulmonary vasodilatation. Am. J. Physiol. 247, H541 - H547.
Grunstein, M. M., Hazinski, T. A., and Schlueter, M. A. (1981) Respiratory control during hypoxia in newborn rabbits: Implied action of endorphins. J. Appl. Physiol. 51, 122–130.
Hamprecht, B. and Van Calker, D. (1985) Nomenclature of adenosine receptors. Trends Pharmacol. Sci. 6, 153–154.
Hansen, J. T. (1985) Ultrastructure of the primate carotid body: A morphometric study of the glomus cells and nerve endings in the monkey (Macaca fascicularis). J. Neurocytol. 14, 13–32.
Harabin, A. L., Peake, M. D., and Sylvester, J. T. (1981) Effect of severe hypoxia on the pulmonary vascular response to vasoconstrictor agents. J. Appl. Physiol. 50, 561–565.
Hauge, A. (1968) Role of histamine in hypoxic pulmonary hypertension in the rat. I. Blockade or potentiation of endogenous amines, kinins and ATP. Circ. Res. 22, 371–383.
Hauge, A., Lunde, P. K. M., and Waaler, B. A. (1966) Vasoconstriction in isolated blood-perfused rabbit lungs and its inhibition by cresols. Acta. Physiol. Scand. 66, 226–240.
Heath, D. and Kay, J. M. (1976) Respiratory system, in Muir’s Textbook of Pathology, 10th Ed. ( Anderson, J. R., ed.) Edward Arnold, London, pp. 378–449.
Hedner, T., Hedner, J., Jonason, J., and Wessberg, P. (1984) Effects of theophylline on adenosine-induced respiratory depression in the preterm rabbit. Eur. J. Respir. Dis. 65, 153–156.
Hess, A. (1968) Electron microscopic observations of normal and experimental cat carotid bodies, in Arterial Chemoreceptors ( Torrance, R. W., ed.) Blackwell, Oxford and Edinburgh, pp. 51–56.
Hess, A. and Zapata, P. (1972) Innervation of the cat carotid body: Normal and experimental studies. Fed. Proc. 31, 1365–1382.
Hogg, J. C., Pare, P. D., Boucher, R. C., Michoud, M. C., Guerzon, G., and Moroz, L. (1977) Pathologic abnormalities in asthma, in Asthma, Physiology, Immunopharmacology and Treatment ( Lichtenstein, L. M., Austen, K. F., and Simon, A. S., eds.) Academic, New York, pp. 1–19.
Holgate, S. T. and Mann, J. S. (1984) Release of adenosine and its metabolites from human leukocytes activated with the calcium ionophore A23187. Br. J. Pharmacol. 82, 262 p.
Holgate, S. T., Lewis, R. A., and Austen, K. F. (1980a) Role of adenylate cyclase in immunologic release of mediators from rat mast cells: Agonist and antagonist effects of purine-and ribose-modified adenosine analogs. Proc. Natl. Acad. Sci. USA 77, 6800–6804.
Holgate, S. T., Lewis, R. A., and Austen, K. F. (1980b) 3’,5’-cyclic adenosine monophosphate-dependent protein kinase of the rat serosal mast cell and its immunologic activation. J. Immunol. 124, 2093–2099.
Holgate, S. T., Cushley, M. J., Mann, J. S., Hughes, P., and Church, M. K. (1986) The action of purines on human airways. Arch. Int. Pharmacodyn. 280, Suppl., 240–252.
Holgate, S. T., Cushley, M. J., Rafferty, P., Beasley, R., Phillips, G., and Church, M. K. (1987) The bronchoconstrictor activity of adenosine in asthma, in Topics and Perspectives in Adenosine Research ( Gerlach, S. and Becker, B. F., ed.), Springer-Verlag, Berlin and Heidelberg, pp. 614–624.
Honey, R. M., Ritchie, W. T., and Thomson, W. A. R. (1930) The action of adenosine upon human heart. PE Q. J. Med. 23, 485–489.
Hughes, P. J., Holgate, S. T., and Church, M. K. (1984) Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism. Biochem. Pharmacol. 33, 3847–3852.
Ishizaka, T. and Ishizaka, K. (1984) Activation of mast cells for mediator release through IgE receptors. Prog. Allergy 34, 188–235.
Jarisch, A., Landgren, A., Neil, E., and Zotterman, Y. (1952) Impulse activity in the caritod sinus nerve following intra-carotid injection of potassium chloride, veratrine, sodium citrate, adenosine-triphosphate and a-dinitrophenol. Acta. Physiol. Scand. 25, 195–211.
Jarisch, A., Landgren, A., Neil, E., and Zotterman, Y. (1952) Impulse activity in the caritod sinus nerve following intra-carotid injection of potassium chloride, veratrine, sodium citrate, adenosine-triphosphate and a-dinitrophenol. Acta. Physiol. Scand. 25, 195–211.
Jeffrey, P. and Corni, B. (1984) Structural analysis of the respiratory tract, in Immunology of the Lung and Upper Respiratory Tract ( Bienenstock, J., ed.), McGraw Hill, New York and Toronto, pp. 1–27.
Jobsis, F. F. (1977) What is a molecular oxygen sensor? What is a transduction process? Adv. Exp. Med. Biol. 78, 3–18.
Kaliner, M. A. (1980) Mast-cell derived mediators and bronchial asthma, in Airway Reactivity, Mechanisms and Clinical Relevance ( Hargreave, F. E., ed.), Astra, Mississauga, Ontario, pp. 175–187.
Karisson, J.-A., Kjellin, G., and Persson, C. G. A. (1982) Effect on tracheal smooth muscle of adenosine and methylxanthines and their interaction. J. Pharm. Pharmacol. 34, 788–793.
Klabund, R. E. (1983) Dipyridamole inhibition of adenosine metabolism in human blood. Eur. J. Pharmacol. 93, 21–26.
Knauer, K. A., Lichtenstein, L. M., Adkinson, N. F., Jr., and Fish, J. E. (1981) Platelet activation during antigen-induced airway reactions in asthmatic subjects. New Engl. J. Med. 304, 1404–1407.
Konche, H. and Kienecker, E.-W. (1977) Sympathetic innervation of the carotid bifurication in the rabbit and cat: Blood vessels, carotid body and carotid sinus. A fluorescence and electron microscopic study. Cell Tissue Res. 184, 103–112.
Kondo, H., Iwanaga, T., and Nakajima, T. (1982) Immunocytochemical study on the localization of neuron-specific enolase and S-100 protein in the carotid body of rats. Cell Tissue Res. 227, 291 295.
Lagercrantz, H., Yamamoto, Y., Fredholmm, B. B., Prabhakar, N. R., and von Euler, C. (1984) Adenosine analogues depress ventilation in rabbit neonates. Theophylline stimulation of respiration via adenosine receptors? Pediatr. Res. 18, 387–390.
Lahiri, S. (1977) Introductory remarks: Oxygen linked response of carotid chemoreceptors. Adv. Exp. Med. Biol. 78, 185–202.
Lahiri, S., Smatresk, N. J., and Mulligan, E. (1983) Responses of peripheral chemoreceptors to natural stimuli, in Physiology of the Peripheral Arterial Chemoreceptors (Acker, H. and O’Regan, R. G., eds.), Elsevier BV, Amsterdam, pp. 221–256.
Lakshminarayan, S., Sahn, S. A., and Weil, J. V. (1978) Effect of aminophylline on ventilatory responses in normal man. Am. Rev. Respir. Dis. 117, 33–38.
Lamb, D. and Lumsden, A. (1982) Intra-epithelial mast cells in human airway epithelium: Evidence for smoking-induced changes in their frequency. Thorax 37, 334–342.
Lande, P. K. M., Waaler, B. A., and Walloe, L. (1968) The inhibitory effect of various phenols upon ATP-induced vasoconstriction in isolated perfused rabbit lungs. Acta Physiol. Scand. 72, 331–337.
Langer, I. (1967) The bronchoconstrictor action of propranolol aerosol in asthmatic subjects. J. Physiol. (Lond.) 190, 41 pp.
Larsson, K. and Sollevi, A. (1988) Influence of infused adenosine on bronchial tone and bronchial reactivity in asthma. Chest 93, 280–284.
Lee, L.-Y. and Milhom, H. T., Jr. (1975) Central ventilatory responses to 02 and CO2 at three levels of carotid chemoreceptor stimulation. Respir. Physiol. 25, 319–333.
Lewis, R. A. and Austen, K. F. (1981) Mediation of local homeostasis and inflammation by leukotrienes and other mast cell-dependent compounds. Nature 293, 103–108.
Lewis, R. A., Soter, N. A., Diamond, P. T., Austen, K. F., Oates, J. A., and Roberts J. L., II (1982) Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE. J. Immunol. 129, 1627–1631.
Londos, C. and Wolff, J. (1977) Two distinct adenosine-sensitive sites on adenylate cyclase. Proc. Natl. Acad. Sci. USA 74, 5482–5486.
Londos, C., Cooper, D. M. F., and Wolff, J. (1980) Subclasses of external adenosine receptors. Proc. Natl. Acad. Sci. USA 77, 2551–2554.
Lugliani, R., Whipp, B. J., Seard, C., and Wasserman, K. (1971) Effect of bilateral carotid-body resection on ventilatory control at rest and during exercise in man. New Engl. J. Med 285, 1105–1111.
McCormack, D. G., Clarke, B., and Barnes, P. J. (1989) Characterization of the adenosine receptors in human pulmonary arteries. Am. J. Physiol. H41 - H46.
McDonald, D. M. and Haskell, A. (1983) Morphology of connections between arterioles and capillaries in the rat carotid body analysed by reconstructing serial sections, in The Peripheral Arterial Chemoreceptors ( Pallot, D. J., ed.), Croom Helm, London and Canberra, pp. 195–206.
McDonald, D. M. and Mitchell, R. A. (1981) The neural pathway involved in “efferent inhibition” of chemoreceptors in the cat carotid body. J. Comp. Neurol. 201, 457–476.
McFadden, E. R. (1984) Pathogenesis of Asthma. J. Allergy Clin. Immunol. 73, 413–424.
McNeil, R. S. and Ingram, C. G. (1966) Effect of propranolol on ventilatory function. Am. J. Cardiol. 18, 473–475.
McQueen (1983) Pharmacological aspects of putative transmitters in the carotid body, in Physiology of the Peripheral Arterial Chemoreceptors ( Acker, H. and O’Regan, R. G., eds.), Elsevier, Amsterdam, pp. 149–195.
McQueen, D. S. and Ribeiro, J. A. (1981a) Effect of adenosine on carotid chemoreceptor activity in the cat. Br. J. Pharmacol. 74, 129–136.
McQueen, D. S. and Ribeiro, J. A. (1981b) Excitatory action of adenosine on cat carotid chemoreceptors. J. Physiol. 315, 38 pp.
McQueen, D. S. and Ribeiro, J. A. (1983) On the specificity and type of receptor involved in carotid body chemoreceptor activation by adenosine in the cat. Br. J. Pharmacol. 80, 347–354.
McQueen, D. S. and Ribeiro, J. A. (1986) Pharmacological characterization of the receptor involved in chemoexcitation induced by adenosine. Br. J. Pharmacol. 88, 615–620.
Mann, J. S. and Holgate, S. T. (1985) Specific antagonism of adenosine-induced bronchoconstriction in asthma by oral theophylline. Br. J. Clin. Pharmacol. 19, 685–692.
Mann, J. S., Cushley, M. J., and Holgate, S. T. (1985) Adenosine induced bronchoconstriction in asthma: Role of parasympathetic stimulation and adrenergic inhibition. Am. Rev. Respir. Dis. 132, 1–6.
Mann, J. S., Holgate, S. T., Renwick, A. G., and Cushley, M. J. (1986a) Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma. J. Appl. Physiol. 61, 1667–1676.
Mann, J. S., Renwick, A. G., and Holgate, S. T. (1986b) Release of adenosine and its metabolites from activated human leukocytes. Clin. Sci. 70, 460–468.
Mannix, S. E., Bye, P., Hughes, J. M. B., Cover, D., and Davies, E. E. (1984) Effect of posture on ventilatory response to steady-state hypoxia and hypercapnia. Respir. Physiol. 58, 87–99.
Marquardt, D. L., Gruber, H. E., and Wasserman, S. I. (1984a) Adenosine release from stimulated mast cells. Proc. Natl. Acad. Sci. USA 81, 6192–6196.
Marquardt, D. L., Parker, C. W., and Sullivan, T. J. (1978) Potentiation of mast cell mediator release by adenosine. J. Immunol. 120, 871–878.
Marquardt, D. L., Walker, L. L., and Wasserman, S. I. (1984b) Adenosine receptors on mouse bone marrow-derived mast cells: Functional significance and regulation by animophylline. J. Immunol. 133, 932–937.
Maxwell, D. L. (1986) Effect of adenosine infusion on resting ventilation in man. J. Physiol. 374, 23 pp.
Maxwell, D. L., Fuller, R. W., Nolop, K. B., Dixon, C. M. S., and Hughes, J. M. B. (1986) Effects of adenosine on ventilatory responses to hypoxia and hypercapnia in humans. J. Appl. Physiol. 61, 1762–1766.
Maxwell, D. L., Fuller, R. W., Conradson, T.-B., Dixon, C. M. S., Aber, V., Hughes, J. M. B., and Barnes, P. J. (1987a) Contrasting effects of two xanthines, theophylline and enprofylline, on the cardio-respiratory stimulation of infused adenosine in man. Acta. Physiol. Scand. 131, 459–465.
Maxwell, D. L., Fuller, R. W., Conradson, T.-B., Dixon, C. M. S., Hughes, J. M. B., and Barnes, P. J. (1987b) Oxygen and theophylline reduce the cardio-respiratory effects of adenosine infusion in man. Clin. Sci. 72, 13 pp.
Mentzer, R. M., Jr., Rubio, R., and Berne, R. M. (1975) Release of adenosine by hypoxic canine lung tissue and its possible role in pulmonary circulation. Am. J. Physiol. 229, 1625–1631.
Milic-Emili, J. and Grunstein, M. M. (1976) Drive and timing components of ventilation. Chest 70, Suppl. 131–133.
Millhorn, D. E., Eldridge, F. L., Kiley, J. P., and Waldrop, T. G. (1984) Prolonged inhibition of respiration following acute hypoxia in glomectomized cats. Respir. Physiol. 57, 331–340.
Mir, A. K., Pallot, D. J., and Nahorski, S. R. (1983) Biogenic amine-stimulated cyclic adenosine 3’,5’-monophosphate formation in the rat carotid body. J. Neurochem. 41, 663–669.
Monteiro, E. C. and Ribeiro, J. A. (1987) Ventilatory effects of adenosine mediated by carotid body chemoreceptors in the rat. Naunyn-Schmiedebergs Arch. Pharmacol. 335, 143–148.
Moss, I. R., Denavit-Saubie, M., Eldridge, F. L., Gillis, R. A., Herkenham, M., and Lahiri, S. (1986) Neuromodulators and transmitters in respiratory control. Fed. Proc. 45, 2133–2147.
Mulligan, E. and Lahiri, S. (1982) Separation of carotid body chemoreceptor responses to 02 and CO2 by oligomycin and by antimycin A. Am. J. Physiol. 242, C200 - C206.
Nadel, J. A. (1973) Neurophysiologic aspects of asthma, in Asthma, Physiology, Immunopharmacology, and Treatment ( Austen, K. F. and Lichtenstein, L. M., eds.), Academic, New York, pp. 29–38.
Obeso, A., Almaraz, L., and Gonzalez, C. (1987) ATP content in the cat carotid body under different experimental conditions. Support for the metabolic hypothesis, in Chemoreceptors inRespiratory Control ( Ribeiro, J. A. and Pallot, D. J., eds.), Croom Helm, London and Sydney, pp. 78–90.
Orehek, J., Gayrard, P., Grimaud, C., and Charpin, J. (1977) Bronchial response to inhaled prostaglandin F2. in patients with common or aspirin-sensitive asthma. J. Allergy Clin. Immunol. 59, 414–419.
Peake, M. D.,Harabin,A. L., Brennan, N. J., and Sylvester, J. T. (1981) Steady-state vascular responses to graded hypoxia in isolated lungs of five species. J. Appl. Physiol. 51, 1214–1219.
Phillis, J. W., Edstrom, J. P., Kostopoulos, G. K., and Kirkpatrick, J. R. (1979) Effects of adenosine and adenosine nucleotides on synaptic transmission in the cerebral cortex. Can. J. Physiol. Pharmacol. 57, 1289–1312.
Proctor, K. G. and Duling, B. R. (1982) Adenosine and free-flow functional hyperaemia in striated muscle. Am. J. Physiol. 242, H688 - H697.
Rebuck, A. S. and Campbell, E. J. M. (1974) A clinical method for assessing the ventilatory response to hypoxia. Am. Rev. Respir. Dis. 109, 345–350.
Reeves, J. T., Jokl, P., Merida, J., and Leathers, J. E. (1967) Pulmonary vascular obstruction following administration of high-energy nucleotides. J. Appl. Physiol. 22, 475–479.
Reid, P. G., Watt, A. H., Routledge, P. A., and Smith, A. P. (1987) Intravenous infusion of adenosine but not inosine stimulates respiration in man. Br. J. Clin. Pharmacol. 23, 331–338.
Ribeiro, J. A. and McQueen, D. S. (1984) Effects of purines on carotid chemoreceptors, in Peripheral Arterial Chemoreceptors (Pallot, D. J., ed.), Oxford University Press, Oxford, pp. 383–390.
Richardson, J. B. (1981) Nonadrenergic inhibitory innervation of the lung. Lung 159, 315–322.
Richardson, P. S., and Sterling, G. M. (1969) Effects of ß-adrenergic receptor blockade on airway conductance and lung volume in normal and asthmatic subjects. Br. Med. J. 3, 143–145.
Richmond, G. H. (1949) Action of caffeine and aminophylline as respiratory stimulants in man. J. Appl. Physiol. 2, 16–23.
Rigatto, H., Brady, J. P., and de la Torre Verduzco, R. (1975) Chemoreceptor reflexes in pretenn infants: 1. The effect of gestational and postnatal age on the ventilatory response to inhalation of 100% and 15% oxygen. Pediatrics 55, 604–613.
Robinson, C. and Holgate, S. T. (1985) Mast cell-dependent inflammatory mediators and their putative role in bronchial asthma. Clin. Sci. 68, 103–112.
Routledge, P. A. and Watt, A. H. (1986) Effect of aminophylline on respiratory stimulation and heart rate changes produced by intravenous adenosine boluses in man. Br. J. Pharmacol. 89, 711 p.
Rubio, R., Berne, R. M., and Dobson, J. G., Jr. (1973) Sites of adenosine production in cardiac and skeletal muscle. Am. J. Physiol. 225, 938–953.
Rubio, R., Berne, R. M., Bockman, E. L., and Cumish, R. R. (1975) Relationship between adenosine concentration and oxygen supply in rat brain. Am. J. Physiol. 228, 1896–1902.
Schleimer, R. P., MacGlashan, D. W., Jr., Schulman, E. S., Peters, S. P., Adkinson, N. F., Jr., Newball, H. H., Adams, G. K., III, and Lichtenstein, L. M. (1982) Effects of glucocorticoids on mediator release from human basophils and mast cells. Fed. Proc. 41, 487.
Sheppard, D., Rizk, N. W., Boushey, H. A., and Bethel, R. A. (1983) Mechanism of cough and bronchoconstriction induced by distilled water aerosol. Am. Rev. Respir. Dis. 127, 691–694.
Sheppard, D., Epstein, J., Holtzman, M. J., Nadel, J. A., and Boushey, H. A. (1982) Dose-dependent inhibition of cold air-induced bronchoconstriction by atropine. J. Appl. Physiol. 53, 169–174.
Sheppard, D., Wong, W. S., Uehara, C. F., Nadel, J. A., and Boushey, H. A. (1980) Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am. Rev. Respir. Dis. 122, 873–878.
Smith, P., Jago, R., and Heath, D. (1982) Anatomical variation and quantative histology of the normal and enlarged carotid body. J. Pathol. 137, 287–304.
Smits, P., Schonten, J., and Thien, T. H. (1987) Respiratory stimulant effects of adenosine in man after caffeine and enprofylline. Br. J. Clin. Pharmacol. 24, 816–819.
Snyder, S. H., Katims, J. J., Annau, Z., Bruns, R. F., and Daly, J. W. (1981) Adenosine receptors and behavioral actions of methylxanthines. Proc. Natl. Acad. Sci. USA 78, 3260–3264.
Stone, T. W. (1984) Purine receptors classification: A point for discussion. Trends. Pharmacol. Sci. 5, 492, 493.
Tenney, S.M. and Brooks, J. G., III. (1966) Carotid bodies, stimulus interaction, and ventilatory control in unanesthetized goats. Respir. Physiol. I, 211–224.
Watt, A. H. and Routledge, P. A. (1985) Adenosine stimulates respiration in man. Br. J. Clin. Pharmacol. 20, 503–506.
Watt, A. H. and Routledge, P.A. (1987) Dipyridamol modulation of heart rate and ventilatory changes produced by intravenous adenosine boluses in man. Br. J. Clin. Pharmacol. 23, 632–633.
Watt, A. H., Reid, P. G., Stephens, M. R., and Routledge, P. A. (1987) Adenosine-induced respiratory stimulation in man depends on site of infusion. Evidence for an action on the carotid body? Br. J. Clin. Pharmacol. 23, 486–490.
Watt, J. G., Dumke, P. R., and Comm, J.H., Jr. (1943) Effects of inhalation of 100 percent and 14 percent oxygen upon respiration of unanaesthetized dogs before and after chemoreceptor denervation. Am. J. Physiol. 138, 61–67.
Wechsler, R. L., Kleiss, L. M., and Kety, S. S. (1950) The effects of intravenously administered aminophylline on cerebral circulation and metabolism in man. J. Clin. Invest. 29, 28–30.
Wessberg, P., Hedner, J., Hedner, T., Person, B., and Jonasen, J. (1985) Adenosine mechanisms in the regulation of breathing in the rat. Eur. J. Pharmaco1. 106, 59–67.
Wetzel, R. C. and Sylvester, J.T. (1983) Gender differences in hypoxic vascular response of isolated sheep lungs. J. Appl. Physiol. 55, 100–104.
Wiklund, N. P., Cederqvist, B., Matsuda, H., and Gustafsson, L. E. (1987) Adenosine can stimulate pulmonary artery. Acta Physiol. Scand. 131, 477–478.
Winn, H. R., Rubio, R., and Berne, R. M. (1981) Brain adenosine concentration during hypoxia in rats. Am. J. Physiol. 241, H235 - H242.
Woodrum, D. E., Standaert, T. A., Maryock, D. E., and Guthrie, R. D. (1981) Hypoxic ventilatory response in the newborn monkey. Pediatr. Res. 15, 367–370.
Wyman, R. J. (1977) Neural generation of the breathing rhythm. Annu. Rev. Physiol. 39, 417–448.
Zapata, P., Stenaas, L. J., and Eyzaguirre, C. (1976) Axon regeneration following a lesion of the carotid nerve: Electrophysiological and ultrastructural observations. Brain Res. 113, 235–253.
Zetterstrom, T., Vernet, L., Ungerstedt, U., Tossman, U., Jonzon, B., and Fredholm, B. B. (1982) Purine levels in the intact rat brain. Studies with an implanted perfused hollow fibre. Neurosci. Leu. 29, 111–115.
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Griffiths, T.L., Holgate, S.T. (1990). The Role of Adenosine in Respiratory Physiology. In: Williams, M. (eds) Adenosine and Adenosine Receptors. The Receptors. Humana Press. https://doi.org/10.1007/978-1-4612-4504-9_10
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