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Role of T Helper Lymphocytes in Autoimmune Diseases

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Pathology Reviews · 1989

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Abstract

A large amount of experimental work on autoimmune diseases has been concentrated on the study of autoantibodies, cytotoxic T lymphocytes (CTL), or on deficiencies of T suppressor cells. The purpose of this review is to present evidence that in many autoimmune diseases, either organ-specific or systemic, T helper (Th) lymphocytes play a predominant role. The importance of the Th cell in autoimmune diseases should come as no surprise, in view of the central role that these cells play in almost all immune responses.

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References

  1. Ackermann HP, Ulrich J, Heitz PU: Experimental allergic encephalomyelitis. Exudate and cellular infiltrate in the spinal cord of Lewis rats. Acta Neuropathol 54: 149, 1981

    PubMed  CAS  Google Scholar 

  2. Adkins B, Mueller C, Okada CY, Reichert RA, Weissman IL, Spangrude GJ: Early events in T-cell maturation. Ann Rev Immunol 5: 325, 1987

    CAS  Google Scholar 

  3. Aichinger G, Fill H, Wick G: In situ immune complexes, lymphocyte populations and HLA-DR positive epithelial cells in Hashimoto thyroiditis. Lab Invest 52: 132, 1985

    PubMed  CAS  Google Scholar 

  4. Allen PM, Babbitt BP, Unanue ER: T cell recognition of lyso-zyme: the biochemical basis of presentation. Immunol Rev 98: 171, 1987

    PubMed  CAS  Google Scholar 

  5. Allison JP: Structure, function, and serology of the T-cell antigen receptor complex. Ann Rev Immunol 5: 503, 1987

    CAS  Google Scholar 

  6. Altman A, Theofilopoulos AN, Weiner R, Katz DH, Dixon FJ: Analysis of T cell function in autoimmune murine strains. Defects in production of and responsiveness to interleukin 2. J Exp Med 154: 791, 1981

    PubMed  CAS  Google Scholar 

  7. Altman A, Theofilopoulos AN, Weiner R, Katz DH, Dixon FJ: Analysis of T cell function in autoimmune murine strains. Defects in production of and responsiveness to interleukin 2. J Exp Med 154: 791, 1981

    PubMed  CAS  Google Scholar 

  8. Arnon R: Experimental allergic encephalomyelitis-susceptibility and suppression. Immunol Rev 58: 5, 1981

    Google Scholar 

  9. Arthur RP, Mason D: T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin-2 on mitogenic or allogeneic stimulation. J Exp Med 163: 774, 1986

    PubMed  CAS  Google Scholar 

  10. Bendelac A, Carnaud C, Boitard C, Bach JF: Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. J Exp Med 166: 823, 1987

    PubMed  CAS  Google Scholar 

  11. Ben-Nun A, Cohen IR: Vaccination against autoimmune encephalomyelitis: attenuated autoimmune T cells confer resistance to induction of active EAE but not to EAE mediated by the intact T lymphocyte line. Eur J Immunol 11: 949, 1981

    PubMed  CAS  Google Scholar 

  12. Ben-Nun A, Wekerle H, Cohen IR: The rapid isolation of clonable, antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur J Immunol 11: 195, 1981

    PubMed  CAS  Google Scholar 

  13. Beschorner WE, Farmer ER, Sarai R, Stirling WL, Santos GW: Epithelial class II antigen expression in cutaneous graft versus host disease. Transplantation 44: 237, 1987

    PubMed  CAS  Google Scholar 

  14. Bjorkman PJ, Saper MA, Samraoui B, Bennett WS, Strominger JL, Wiley DC: The foreign antigen-binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329: 512, 1987

    PubMed  CAS  Google Scholar 

  15. Bluestone JA, Pardoll D, Sharrow SO, Fowlkes BJ: Characterization of murine thymocytes with CD3-associated T cell receptor structures. Nature 326: 82, 1987

    PubMed  CAS  Google Scholar 

  16. Boitard C, Bach JF: Cell-mediated versus humoral immunity in autoimmune diseases and their pharmacologic control with particular reference to type 1 diabetes mellitus. In Concepts in Immunopathology, Vol 3, edited by Cruse JM, Lewis RE, p 193. Basel, Karger, 1986

    Google Scholar 

  17. Boitard C, Debray-Sachs M, Pouplard A, Assan R, Hamburger J: Lymphocytes from diabetics suppress insulin release in vitro. Diabetologia 21: 41, 1981

    PubMed  CAS  Google Scholar 

  18. Boitard C, Chatenoud LM, Debray-Sachs M: In vitro inhibition of pancreatic B cells by T lymphocytes in diabetes. J Immunol 129: 2529, 1982

    PubMed  CAS  Google Scholar 

  19. Bottazzo GF, Dean BM, McNally JM, McKay EH, Swift PGF, Gamble DR: In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med 313: 353, 1985

    PubMed  CAS  Google Scholar 

  20. Bottazzo GF, Todd I, Mirakian R, Belfiore A, Pujol-Borrell R: Organ-specific autoimmunity: a 1986 overview. Immunol Rev 94: 137, 1986

    PubMed  CAS  Google Scholar 

  21. Burkart V, Apples B, Kolb H: In vitro cytotoxic activity of macrophages against isolated islet cells (abstr). Diabetes 37 (Suppl): 21A, 1988

    Google Scholar 

  22. Burkart V, Apples B, Kolb H: In vitro cytotoxic activity of macrophages against isolated islet cells (abstr). Diabetes 37 (Suppl): 21A, 1988

    Google Scholar 

  23. Cantor H, McVay-Boudreau L, Hugenberger J, Naidorf K, Shen FW, Gershon RK: Immunoregulatory circuits among T cell sets. II. Physiological role of feedback inhibition in vivo: absence in NZB mice. J Exp Med 147: 1116, 1978

    PubMed  CAS  Google Scholar 

  24. Carson DA, Chen PP, Kipps TJ, Radoux V, Jirik F, Goldfien RD, Fox RI, Silverman GJ, Fong S: Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors). In Autoimmunity and Autoimmune Disease, edited by Evered D, Whelan J, p 123. Chichester, John Wiley and Sons, 1987

    Google Scholar 

  25. Charron D, Teyton L: Autoimmunity in rheumatoid arthritis. In Concepts in Immunopathology, Vol 4, edited by Cruse JM, Lewis RE, p 200. Basel, Karger, 1987

    Google Scholar 

  26. Cher DJ, Mosmann TR: Two types of murine helper T cell clone. 2. Delayed -type hypersensitivity is mediated by Thl clones. J Immunol 138: 3688, 1987

    PubMed  CAS  Google Scholar 

  27. Cherwinski HM, Schumaker JH, Brown KD, Mosmann TR: Two types of mouse helper T cell clone: J Exp Med 166: 1229, 1987

    PubMed  CAS  Google Scholar 

  28. Chused TM, McCoy KL, Lai RB, Brown EL, Bake PJ: Multigenic basis of autoimmune disease in New Zealand mice. In Concepts in Immunopathology, Vol 4, edited by Cruse JM, Lewis RE, p 129. Basel, Karger, 1987

    Google Scholar 

  29. Cohen IR: Regulation of autoimmune disease: physiological and therapeutic. Immunol Rev 94: 5, 1986

    PubMed  CAS  Google Scholar 

  30. Combe B, Pope RM, Fishbach M, Darnell B, Baron S, Talal N: Interleukin 2 in rheumatoid arthritis: production of and response to IL-2 in rheumatoid synovial fluid, synovial tissue and peripheral blood. Clin Exp Immunol 59: 520, 1985

    PubMed  CAS  Google Scholar 

  31. Creighton WD, Katz DH, Dixon FJ: Antigen-specific immuno-competency, B cell function and regulatory helper and suppressor T cell activities in spontaneously autoimmune mice. J Immunol 123: 2627, 1979

    PubMed  CAS  Google Scholar 

  32. Cresswell P: Antigen recognition by T lymphocytes. Immunol Today 8: 67, 1987

    Google Scholar 

  33. Dean BM, Walker R, Boen AJ, Baird JD, Cooke A: Pre-diabetes in the spontaneously diabetic BB/E rat: lymphocyte subpopula-tions in the pancreatic infiltrate and expression of rat MHC class II molecules in endocrine cells: Diabetologia 28: 614, 1985

    Google Scholar 

  34. De Baets MH: Autoimmune endocrine diseases. In Concepts in Immunopathology, Vol 2, edited by Cruse JM, Lewis RE, p 1. Basel, Karger, 1985

    Google Scholar 

  35. Debray-Sachs M, Boitard C, Assau R, Hamburger J: Are activated macrophages cytotoxic against normal cells. Transplant Proc 13: 1111, 1981

    PubMed  CAS  Google Scholar 

  36. Dixon FJ, Theofilopoulos AN, McConahey P, Prud’homme GJ: Murine systemic lupus erythematosus (SLE). In Progress in Immunology V, edited by Yamamura Y, Tada T, p 1115. Japan, Academic Press, 1983

    Google Scholar 

  37. Dobashi K, Ono S, Murakami S, Takahama Y, Katoh Y, Hamaoka T: Polyclonal B cell activation by a cell differentiation factor, B151–TRF2. III. B151–TRF2 as a B cell differentiation factor closely associated with autoimmune disease. J Immunol 138: 780, 1987

    PubMed  CAS  Google Scholar 

  38. Dobersen MJ: Humoral autoimmune aspects of insulin dependent diabetes mellitus. In Concepts in Immunopathology, Vol 2, edited by Cruse JM, Lewis RE, p 32. Basel, Karger, 1985

    Google Scholar 

  39. Dolph OA, Hamilton TA: Molecular transductional mechanisms by which interferon gamma and other signals regulate macrophage development. Immunol Rev 97: 5, 1987

    Google Scholar 

  40. Durum SK, Schmidt JA, Oppenheim JJ: Interleukin 1: an immunological perspective. Ann Rev Immunol 3: 263, 1985

    CAS  Google Scholar 

  41. Dyrberg T, Nakhooda AF, Baekkeskov S, Lernmark A, Poussier P, Marliss EB: Islet cell surface antibodies and lymphocyte antibodies in the spontaneously diabetic BB Wistar rat. Diabetes 31: 278, 1982

    PubMed  CAS  Google Scholar 

  42. Dziarski R: Preferential induction of autoantibody secretion in polyclonal activation by peptidoglycan and lipopolysaccharide. J Immunol 128: 1026, 1982

    PubMed  CAS  Google Scholar 

  43. Emery P, Williamson DJ, Mackay IR: Role of cytokines in rheu-matological inflammation. In Concepts in Immunopathology, Vol 4, edited by Cruse JM, Lewis RE, p 171. Basel, Karger, 1987

    Google Scholar 

  44. Fauci AS: Immunoregulation and autoimmunity: J Allergy Clin Immunol 66: 5, 1980

    PubMed  CAS  Google Scholar 

  45. Feldmann M: Regulation of HLA class II expression and its role in autoimmune disease. In Autoimmunity and Autoimmune Disease, edited by Evered D, Whelan J, p 88. Chichester, John Wiley and Sons, 1987

    Google Scholar 

  46. Fish F, Ziff M: The in vitro and in vivo induction of anti-double stranded DNA antibodies in normal and autoimmune mice. J Immunol 128: 409, 1982

    PubMed  CAS  Google Scholar 

  47. Forbes RDC, Parfrey NA, Gomersall M, Darden AG, Guttmann RD: Dendritic cell-lymphoid cell aggregation and major histocompatibility expression during rat cardiac allograft rejection. J Exp Med 164: 1239, 1986

    PubMed  CAS  Google Scholar 

  48. Foulis AK, Farquharson MA: Aberrant expression of HLA-DR antigens by insulin-containing beta cells in recent-onset type I diabetes mellitus: Diabetes 35: 1215, 1986

    PubMed  CAS  Google Scholar 

  49. Freund J, Stern ER, Pisani TM: Isoallergic encephalomyelitis in guinea pigs after one injection of brain and mycobacteria in water-in-oil emulsion. J Immunol 57: 179, 1947

    PubMed  CAS  Google Scholar 

  50. Garman RG, Jacobs KA, Clark SC, Raulet DH: BSF2 (beta2 interferon) functions as a second signal for IL-2 production by mature murine T cells. Proc Natl Acad Sci USA 84: 7629, 1987

    PubMed  CAS  Google Scholar 

  51. Gay D, Maddon P, Sekaly R, Talle MA, Godfrey M, Long E, Goldstein G, Chess L, Axel R, Kappler J, Marrack P: Functional interaction between human T cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature 328: 626, 1987

    PubMed  CAS  Google Scholar 

  52. Gefler M, Marrack P: Development and modification of the lymphocyte repertoire. Nature 321: 116, 1986

    Google Scholar 

  53. Gepts W: Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 14: 619, 1965

    PubMed  CAS  Google Scholar 

  54. Gillis S: Interleukin-2: biology and biochemistry. J Clin Immunol 3: 1, 1983

    PubMed  CAS  Google Scholar 

  55. Gleichmann E, VanElven EH, Vander Veen JPW: A systemic lupus erythematosus-like disease in mice induced by abnormal T- B cooperation. Preferential formation of autoantibodies characteristic of SLE. Eur J Immunol 12: 152, 1982

    PubMed  CAS  Google Scholar 

  56. Greene WC, Depper JM, Kronke M, Leonard WJ: The human interleukin 2 receptor analysis of structure and function. Immunol Rev 92: 29, 1986

    PubMed  CAS  Google Scholar 

  57. Greiner DL, Mordes JP, Handler ES, Angelillo M, Nakamura N, Rossini AA: Depletion of RT6.1+ T lymphocytes induces diabetes in resistant BB/W rats. J Exp Med 166: 461, 1987

    PubMed  CAS  Google Scholar 

  58. Gromo G, Geller RL, Inverardi L, Bach FH: Signal requirements in a step-wise functional maturation of cytotoxic T lymphocytes. Nature 327: 424, 1987

    PubMed  CAS  Google Scholar 

  59. Guttmann RD, Colle E, Michel F, Seemayer T: Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. J Immunol 130: 1732, 1983

    PubMed  CAS  Google Scholar 

  60. Hall BM, Bishop GA, Duggin GG, Horvath JS, Philips J, Tiller DJ: Increased expression of HLA-DR antigens on renal tubular cells in renal transplants: relevance to the rejection response. Lancet 2: 247, 1984

    PubMed  CAS  Google Scholar 

  61. Hamaoka T, Ono S: Regulation of B-cell differentiation. Ann Rev Immunol 4: 167, 1986

    CAS  Google Scholar 

  62. Hanafusa T, Pujol-Borrell R, Chiovato L, Russell RCG, Doniach D, Bottazzo GF: Aberrant expression of HLA-DR antigen on thyrocytes in Grave’s disease: relevance for autoimmunity. Lancet ii: 1111, 1983

    Google Scholar 

  63. Hang L, Slack JH, Amundson C, Izui S, Theofilopoulos AN, Dixon FJ: Induction of murine autoimmune disease by chronic polyclonal B cell activation. J Exp Med 157: 874, 1983

    PubMed  CAS  Google Scholar 

  64. Hang LM, Theofilopoulos AN, Dixon FJ: A spontaneous rheumatoid arthritis-like disease in MRL/1 mice. J Exp Med 155:1690,1982.

    PubMed  CAS  Google Scholar 

  65. Hashim GA: Myelin basic protein: structure, function and antigen determinants. Immunol Rev 39: 60, 1978

    PubMed  CAS  Google Scholar 

  66. Herberman RB: Multiple functions of natural killer cells, including immunoregulation as well as resistance to tumor growth. In Concepts in Immunopathology, Vol 1, edited by Cruse JM, Lewis RE, p 96, Basel, Karger, 1985

    Google Scholar 

  67. Herzenberg LA, Stall AM, Lalor PA, Sidman C, Moore WA, Parks DR, Herzenber LA: The Ly-1 B cell lineage. Immunol Rev 93: 81, 1986

    PubMed  CAS  Google Scholar 

  68. Hinrichs DJ, Wegmann KW, Dietsch GN: Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element. J Exp Med 166: 1906, 1987

    PubMed  CAS  Google Scholar 

  69. Hirano T, Yasukawa K, Harada H, Taga T, Watanabe Y, Matsuda T, Kashiwamura S-I, Nakajima K, Koyama K, Iwamatsu A, Tsunasawa S, Sakiyama F, Matsui K, Takahara Y, Taniguchi T, Kishimoto T: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73, 1986

    PubMed  CAS  Google Scholar 

  70. In’t Veld PA, Van De Winkel M, Markholst H, Rozing J, Gepts W, Pipeleers DG: Insulin-reactivity of non-endocrine la postive islet cells (abstr). Diabetes 37 (Suppl): 6A, 1988

    Google Scholar 

  71. Isenberg D, Shoenfeld Y: The origin and significance of anti-DNA antibodies. Immunol Today 8: 279, 1987

    CAS  Google Scholar 

  72. Jabs DA, Prendergast RA: Reactive lymphocytes in lacrimal gland and vasculitic renal lesions of autoimmune MRL/lpr mice express L3T4. J Exp Med 166: 1198, 1987

    PubMed  CAS  Google Scholar 

  73. Jansson R, Karlsson A, Forsum U: Intrathyroid HLA-DR expression and T lymphocyte phenotypes in Graves’s thyrotoxicosis, Hashimoto’s thyroiditis and nodular colloid goitre. Clin Exp Immunol 58: 264, 1985

    Google Scholar 

  74. Jenkinson EJ, Jhittay P, Kingston R, Owen JJ: Studies of the role of the thymic microenvironment in the induction of tolerance to HMC antigens. Transplantation 39: 331, 1985

    PubMed  CAS  Google Scholar 

  75. Kabat EA, Wolf A, Bezer AE: Rapid production of acute disseminated encephalomyelitis in rhesus monkey by injection of heterologous and homologous brain tissue with adjuvants. J Exp Med 85: 117, 1947

    PubMed  CAS  Google Scholar 

  76. Katooka S, Stoh J, Fujiya H, Toyota T, Suzuki R: Immunologic aspects of the non-obese diabetic (NOD) mouse. Diabetes 32:247,1983.

    Google Scholar 

  77. Kibler RF, Fritz RB, Chou FC-H, Chou C-HJ, Peacocke NY, Brown NM, McFarlin DF: Immune response of Lewis rats to peptide CI (residues 68–88) of guinea pig and rat myelin basic proteins. J Exp Med 146: 1323, 1977

    PubMed  CAS  Google Scholar 

  78. Kinashi T, Harada N, Severinson E, Tanabe T, Sideras P, Konishi M, Azuma C, Tominaga A, Bergstedt-Lindqvist S, Takahashi M, Matsuda F, Yaoita Y, Takatsu K, Honjo T: Cloning of complementary DNA encoding T-cell replacing factor and identity with B cell-growth factor II. Nature 324: 70, 1986

    PubMed  CAS  Google Scholar 

  79. Kingston R, Jenkinson EJ, Owen JJT: A single stem cell can recolonise an embryonic thymus producing phenotypically distinct T-cell populations. Nature 317: 811, 1985

    PubMed  CAS  Google Scholar 

  80. Klareskog L, Forsum U, Scheynius A, Kabelitz D, Wigzell H: Evidence in support of a self-perpetuating HLA-DR-dependent delayed-type cell reaction in rheumatoid arthritis. Proc Natl Acad Sci USA 72: 3632, 1982

    Google Scholar 

  81. Klasen IS, Ladestein RMT, Donselaar IG, Van Den Berg WB, Tees R, Benner R: Joint inflammation in mice induced by a MT4+ Lyt2- T cell clone. J Immunol 139: 3275, 1987

    PubMed  CAS  Google Scholar 

  82. Klinman DM, Steinberg AD: Systemic autoimmune disease arises from polyclonal B cell activation. J Exp Med 165: 1755, 1987

    PubMed  CAS  Google Scholar 

  83. Koevary S, Rossini AA, Stoller W, Chich W, Williams RM: Passive transfer of diabetes in the BB/W rat. Science 220: 727, 1983

    PubMed  CAS  Google Scholar 

  84. Koevary S, Williams RM, Stoller W, Chick W: Passive transfer of diabetes in BB/W and WF rats (abstr). Diabetes 32: 200, 1983

    Google Scholar 

  85. Kofler R, Dixon FJ, Theofilopoulos AN: The genetic origin of autoantibodies. Immunol Today 8: 374, 1987

    Google Scholar 

  86. Krakauer RS, Waldmann TA, Strober W: Loss of suppressor T cells in adult NZB/NZW mice. J Exp Med 144: 662, 1976

    PubMed  CAS  Google Scholar 

  87. Kronenberg M, Siu G, Hood LE, Shastri N: The molecular genetics of the T-cell antigen receptor and T-cell antigen recognition. Ann Rev Immunol 4: 529, 1986

    CAS  Google Scholar 

  88. Kruisbeek A, Mond J, Fowlkes BJ, Carmen J, Bridges S, Longo DL: Abscence of the Lyt-2-, L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intra-thymic I-A bearing antigen-presenting cell. J Exp Med 161:1029,1982.

    Google Scholar 

  89. Kurt-Jones EA, Hamberg S, Ohara J, Paul WE, Abbas AK: Heterogeneity of helper/inducer T lymphocytes. J Exp Med 166: 1774, 1987

    PubMed  CAS  Google Scholar 

  90. Lampert IA, Suitters AJ, Chisholm PM: Expression of la antigen on epidermal keratinocytes in graft vs host disease. Nature 293: 149, 1981

    PubMed  CAS  Google Scholar 

  91. Laupacis A, Gardell C, Dupre J, Stiller CR, Keown P, Wallace AC: Cyclosporin prevents diabetes in BB Wistar rats. Lancet i: 10, 1983

    Google Scholar 

  92. Lernhardt W, Karasuyama H, Rolind A, Melchers F: Control of the cell cycle of murine B lymphocytes: The nature of alpha and beta-B-cell growth factors and of B-cell maturation factors. Immunol Rev 99: 241, 1987

    PubMed  CAS  Google Scholar 

  93. Li JH, Shevach EM, Mizuguchi J, Ohara J, Mosmann T, Paul WE: B cell stimulatory factor 1 (IL-4) is a potent costimulant for normal resting T lymphocytes. J Exp Med 165: 157, 1987

    Google Scholar 

  94. Like AA, Biron CA, Weringer EJ, Byman K, Sroczynski E, Guberski DL: Prevention of diabetes in BB rats with monoclonal antibodies that recognize T lymphocytes or natural killer cells. J Exp Med 164: 1145, 1986

    PubMed  CAS  Google Scholar 

  95. Like AA, Kislauskis E, Williams RM, Rossini AA: Neonatal thymectomy prevents spontaneous diabetes mellitus in the BB/ W rat. Science 216: 644, 1982

    PubMed  CAS  Google Scholar 

  96. Like AA, Weringer EJ, Holdash A, McGill P, Atkinson D, Rossini AA: Adoptive transfer of autoimmune diabetes mellitus in BB/W inbred and hybrid rats. J Immunol 134: 1583, 1985

    PubMed  CAS  Google Scholar 

  97. Linker-Israeli M, Bakke AC, Kitridou RC, Gendler S, Gillis S, Horwitz DA: Defective production of IL-1 and IL-2 in patients with systemic lupus erythematosus. J Immunol 130: 2651, 1983

    PubMed  CAS  Google Scholar 

  98. Littman DR: The structure of the CD4 and CDS genes. Ann Rev Immunol 5: 561, 1987

    CAS  Google Scholar 

  99. Lo D, Sprent J: Identity of cells that imprint H-2-restricted T- cell specificity in the thymus. Nature 319: 672, 1986

    PubMed  CAS  Google Scholar 

  100. Logothetopoulos J, Valiquette N, MacGregor D, Hsia T: Transfer of Diabetes in neonatal rats: tissue localization of injected blasts. Diabetes 36: 1116, 1987

    PubMed  CAS  Google Scholar 

  101. Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien Y-H, Weiss A: Identification and sequence of a fourth human T cell antigen receptor chain. Nature 330: 569, 1987

    PubMed  CAS  Google Scholar 

  102. Londei M, Bottazzo GF, Feldmann M: Human T cell clones from autoimmune thyroid glands: specific recognition of autologous thyroid cells. Science 228: 85, 1985

    PubMed  CAS  Google Scholar 

  103. Londei M, Lamb JR, Bottazzo GF, Feldmann M: Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells. Nature 312: 639, 1984

    PubMed  CAS  Google Scholar 

  104. Longo DL, Davis ML: Early appearance of donor-type antigen-presenting cells in the thymus of 1200 R radiation-induced bone marrow chimeras correlates with self-recognition of donor I region gene products. J Immunol 130: 2525, 1983

    PubMed  CAS  Google Scholar 

  105. Mahi-Brown CA, Yule TD, Tung KSK: Adoptive transfer of murine autoimmune orchitis to naive recipients with immune lymphocytes. Cell Immunol 106: 408, 1987

    PubMed  CAS  Google Scholar 

  106. Mandrup-Poulsen T, Bendtzen K, Nerup J, Dinarello CA, Svenson M, Nielsen JH: Affinity-purified human I 7 interleukin 1 is cytotoxic to isolated islets of Langerhans. Diabetologia 29:63, 1986

    PubMed  CAS  Google Scholar 

  107. Mandrup-Poulsen T, Bendtzen K, Nerup J, Egeberg J, Nielsen JH: Mechanisms of pancreatic islet destruction: dose-dependent cytotoxic effect of soluble blood mononuclear cell mediators on isolated islet of Langerhans. Allergy 41: 250, 1986

    PubMed  CAS  Google Scholar 

  108. Mandrup-Poulsen T, Bendtzen, Nielsen JH, Bendenes G, Nerup J: Cytokines cause functional and structural damage to isolated islets of Langerhans. Allergy 40: 424, 1985

    PubMed  CAS  Google Scholar 

  109. Markmann JF, Hichey WF, Kimura H, Woehrle M, Barker CF, Naji A: Gamma interferon induces novel expression of la antigens by rat pancreatic islet endocrine cells. Pancreas 2: 258, 1987

    PubMed  CAS  Google Scholar 

  110. Marliss EB, Nakhooda AF, Poussier P, Sima AAF: The diabetic syndrome of the BB rat: possible relevance to type 1 (insulin-dependent) diabetes in man. Diabetologia 22: 225, 1982

    PubMed  CAS  Google Scholar 

  111. Miescher GC, Budd RC, Lees RK, MacDonald HR: Abnormal expression of T cell receptor genes in Lyt2-, L3T4+ lymphocytes of lpr mice: comparison with normal immature thymocytes. J Immunol 138: 1959, 1987

    PubMed  CAS  Google Scholar 

  112. Milich DR: Genetic and Molecular basis for T- and B-cell recognition of hepatitis B viral antigens. Immunol Rev 99: 71, 1987

    PubMed  CAS  Google Scholar 

  113. Miller BJ, Appel MC, O’Neil JJ, Wicker LS: Adoptive transfer of T cell subsets in NOD mice (abstr). Diabetes 37 (Suppl): 4A, 1988

    Google Scholar 

  114. Mordes JP, Desemone J, Rossini AA: The BB rat: Diab Metab Rev 3: 725, 1987

    CAS  Google Scholar 

  115. Morgan I: Allergic encephalomyelitis in monkeys in response to injection of normal monkey nervous tissue. J Exp Med 85: 131, 1947

    PubMed  CAS  Google Scholar 

  116. Morrison LR: Disseminated encephalomyelitis experimentally produced by use of homologous antigen. Arch Neurol Psychiatry 58: 391, 1947

    PubMed  CAS  Google Scholar 

  117. Mosmann TR, Coffman RL: Two types of mouse helper-T cell clone. Immunol Today 8: 223, 1987

    Google Scholar 

  118. Naji A, Silvers WK, Barker CF: Autoimmunity and type I (insu-lin-dependent) diabetes mellitus. Transplantation 36: 355, 1983

    PubMed  CAS  Google Scholar 

  119. Nerup J, Andersen OO, Bendixen G, Egeverg J, Poulsen JE: Antipancreatic cellular hypersensitivity in diabetes mellitus. Diabetes 20: 424, 1971

    PubMed  CAS  Google Scholar 

  120. Ortiz-Ortiz L, Nakamura RM, Weigle WO: T cell requirement for experimental allergic encephalomyelitis induction in the rat. J Immunol 117: 576, 1976

    PubMed  CAS  Google Scholar 

  121. Oschilewski V, Kiesel V, Kolb H: Administration of silica prevents diabetes in BB rats. Diabetes 34: 197, 1985

    PubMed  CAS  Google Scholar 

  122. Oschilewski V, Kiesel V, Kolb H: Administration of silica prevents diabetes in BB rats. Diabetes 34: 197, 1985

    PubMed  CAS  Google Scholar 

  123. Oschilewski V, Kiesel V, Kolb H: Administration of silica prevents diabetes in BB rats. Diabetes 34: 197, 1985

    PubMed  CAS  Google Scholar 

  124. Paterson, PY, Day ED, Whitacare CC: Neuroimmunologic Diseases: Effector cell responses and immunoregulatory mechanisms. Immunol Rev 55: 89, 1981

    PubMed  CAS  Google Scholar 

  125. Paul WE, Ohara J: B-cell stimulatory factor-1/interleukin 4. Ann Rev Immunol 5: 429, 1987

    CAS  Google Scholar 

  126. Penhale WJ, Farmer A, Irvine WJ: Thyroiditis in T cell depleted rats. Clin Exp Immunol 21: 362, 1975

    PubMed  CAS  Google Scholar 

  127. Pfeifer JD, McKenzie DT, Swain SL, Dutton RW: B cell stimulatory factor 1 (IL-4) is sufficient for the proliferation and differentiation of lectin-stimulated CTL precursors. J Exp Med 166: 1464, 1987

    PubMed  CAS  Google Scholar 

  128. Pike BL, Alderson MR, Nossal GJV: T-independent activation of single B cells: an orderly analysis of overlapping stages in thee activation pathway. Immunol Rev 99: 119, 1987

    PubMed  CAS  Google Scholar 

  129. Pontes de Carvalho L, Wick G, Roitt IM: Requirement of T cells for the development of spontaneous autoimmune thyroiditis in obese strain chickens. J Immunol 126: 750, 1981

    Google Scholar 

  130. Prud’homme GJ, Balderas RS, Dixon FJ, Theofilopoulos AN: B cell dependence on and response to accessory signals in murine lupus strains. J Exp Med 157: 1815, 1983

    PubMed  Google Scholar 

  131. Prud’homme, GJ, Colle E, Fuks A, Goldner-Sauve A, Guttmann RD: Cellular immune abnormalities and autoreactive T lymphocytes in insulin-dependent diabetes mellitus in rats. Immunol Today 6: 160, 1985

    Google Scholar 

  132. Prud’homme GJ, Colle E, Fuks A, Guttmann RD: Major histocompatibility complex restriction of T lymphocyte responses to islet cell antigens in IDDM rats. Diabetes 36: 237, 1987

    PubMed  Google Scholar 

  133. Prud’homme GJ, Fieser TM, Dixon FJ, Theofilopoulos AN: B cell-tropic interleukins in murine systemic lupus erythematosus (SLE). Immunol Rev 78: 159, 1984

    PubMed  Google Scholar 

  134. Prud’homme GJ, Fuks A, Colle E, Guttmann RD: Isolation of T lymphocyte lines with specificity for islet cell antigens from spontaneously diabetic (insulin-dependent) rats. Diabetes 33: 801, 1984

    PubMed  Google Scholar 

  135. Prud’homme GJ, Fuks A, Colle E, Seemayer TA, Guttmann RD: Immune dysfunction in diabetes-prone BB rats. J Exp Med 159: 463, 1984

    PubMed  Google Scholar 

  136. Prud’homme GJ, Fuks A, Guttmann RD, Colle E: T cell hybrids with specificity for islet cell antigens. J Immunol 151: 1535, 1986

    Google Scholar 

  137. Prud’homme GJ, Lapchak P, Parfrey NA, Colle E, Guttmann RD: Autoimmunity-prone BB rats lack functional cytotoxic T cells. Cell Immunol 114: 198, 1988

    PubMed  Google Scholar 

  138. Prud’homme GJ, Park CL, Feiser TM, Kofler R, Dixon FJ, Theofilopoulos AN: Identification of a B cell differentiation factor (s) spontaneously produced by proliferating T cells in murine lupus strains of the lpr/lpr genotype. J Exp Med 157: 730, 1983

    PubMed  Google Scholar 

  139. Prud’homme GJ, Sohn U, Delovitch TL: The role of H-2 and la antigens in graft-vs-host reactions. J Exp Med 149: 137, 1979

    PubMed  Google Scholar 

  140. Pujol-Borrell R, Todd I, Doshi M, Bottazzo GF, Sutton R, Gray D, Adolf GR, Feldmann M: HLA class II induction in human islet cells by interferon gamma plus tumor necrosis factor or lympho-toxin: Nature 326: 364, 1987

    Google Scholar 

  141. Pujol-Borrell R, Todd I, Doshi M, Gray D, Feldmann M, Bottazzo GF: Differential expression and regulation of MHC products in the endocrine and exocrine cells of the human pancreas. Clin Exp Immunol 65: 128, 1986

    PubMed  CAS  Google Scholar 

  142. Pukel C, Baquerizo, Rabinovitch A: Interleukin 2 activates BB/ W diabetic rat lymphoid cells cytotoxic to islet cells. Diabetes 36: 1217, 1987

    PubMed  CAS  Google Scholar 

  143. Pukel C, Baquerizo H, Rabinovitch A: Leukocyte associated polypeptides (cytokines) involved in cytolysis of islet cells in vitro (abstr). Diabetes 37 (Suppl): 7A, 1988

    Google Scholar 

  144. Rabin BS, Griffith BP, Hardesty RL: Vascular endothelial cell HLA-DR antigen and myocyte necrosis in human allograft rejection. Heart Transplant 4: 293, 1985

    CAS  Google Scholar 

  145. Rivers TM, Schwentker FF: Encephalomyelitis accompanied by myelin destruction experimentally produced in monkeys. J Exp Med 61: 689, 1935

    PubMed  CAS  Google Scholar 

  146. Rivers TM, Sprunt DH, Berry GP: Observations on attempt to produce acute disseminated encephalomyelitis in monkeys. J Exp Med 58: 39, 1933

    PubMed  CAS  Google Scholar 

  147. Romball CG, Weigle WO: Transfer of experimental autoimmune thyroiditis with T cell clones. J Immunol 138: 1092, 1987

    PubMed  CAS  Google Scholar 

  148. Ron Y, Sprent J: T cell priming in vivo: a major role for B cells in presenting antigen to T cells in lymph nodes. J Immunol 138: 2848, 1987

    PubMed  CAS  Google Scholar 

  149. Rose NR, Bacon LD, Sundick RS, Kong YM, Esquivel P, Bigazzi PE: Genetic regulation in autoimmune thyroiditis. In Autoimmunity, edited by Talal N, p 63. New York, Academic Press, 1977

    Google Scholar 

  150. Rossini AA, Mordes JP, Like AA: Immunology of insulin dependent diabetes mellitus. Ann Rev Immunol 3: 289, 1985

    CAS  Google Scholar 

  151. Rossini AA, Williams RM, Mordes JP, Appel MC, Like AA: Spontaneous diabetes in the gnotobiotic BB/W rat. Diabetes 28: 1031, 1979

    PubMed  CAS  Google Scholar 

  152. Royer HD, Ramarli D, Acuto O, Campen TJ, Reinherz EL: Genes encoding the T cell receptor Ti alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny. Proc Natl Acad Sei USA 82: 5510, 1985

    CAS  Google Scholar 

  153. Rudd CE, Morimoto C, Wong LL, Schlossman SF: The subdivision of the T4 (CD4) subset on the basis of the differential expression of L-C/T200 antigens. J Exp Med 166: 1758, 1987

    PubMed  CAS  Google Scholar 

  154. Ruddle NH: Lymphotoxin production in AIDS. Immunol Today 7: 8, 1986

    Google Scholar 

  155. Samelson LE, Lindsten T, Fowlkes BJ, Van Den Elsen P, Terhorst C, Davis MM, Germain RN, Schwartz RH: Expression of genes of the T-cell antigen receptor complex in precursor thymocytes. Nature 315: 765, 1985

    PubMed  CAS  Google Scholar 

  156. Schlomchik MJ, Marshak-Rothstein, Wolfowicz CB, Rothstein TL, Weigert MG: The role of clonal selection and somatic mutation in autoimmunity. Nature 328: 805, 1987

    Google Scholar 

  157. Schräder JW: The panspecific hemopoietin of activated T lymphocytes (interleukin 3). Ann Rev Immunol 4: 205, 1986

    Google Scholar 

  158. Schwartz RS: Monoclonal lupus autoantibodies. Immunol Today 4: 68, 1983

    Google Scholar 

  159. Schwizer RW, Leiter EH, Evans R: Macrophage mediated cytotoxicity against cultured pancreatic islet cells. Transplantation 37: 539, 1984

    PubMed  CAS  Google Scholar 

  160. Seemayer TA, Tannenbaum GS, Goldman H, Colle E: Dynamic time course studies of the spontaneously diabetic BB Wistar rat. Am J Pathol 106: 237, 1982

    PubMed  CAS  Google Scholar 

  161. Shortman K, Scollay R, Wilson A, Chen WF, Ewing T: Mature and immature thymocytes. In Progress in Immunology, Vol VI, edited by Cinader B, Miller RG, p 95. Orlando, Academic Press, 1986

    Google Scholar 

  162. Sibley R, Sutherland DER, Goetz F, Michael AK: Recurrent diabetes mellitus in the pancreas iso-and allograft. Lab Invest 53: 132, 1985

    PubMed  CAS  Google Scholar 

  163. Sidman CL, Marshall JD, Shultz LD, Gray PW, Johnson HM: Gamma interferon is one of several direct B cell maturing lymphognes. Nature 309: 801, 1984

    PubMed  CAS  Google Scholar 

  164. Simon J, Anzil AP: Immunohistological evidence of perivascular localization of basic protein in early development of EAE: Acta Neuropathol 27: 33, 1974

    PubMed  CAS  Google Scholar 

  165. Smith HR, Steinberg AD: Autoimmunitya perspective. Ann Rev Immunol 1: 175, 1983

    CAS  Google Scholar 

  166. Snapper CM, Paul WE: Interferon gamma and BSF-1 reciprocally regulated Ig isotype production. Science 236: 944, 1987

    PubMed  CAS  Google Scholar 

  167. Sobel RA, Blanchette BW, Bhan AK, Colvin RB: The immuno-pathology of experimental allergic encephalomyelitis. II. Endothelial cell la increases prior to inflammatory cell infiltration. J Immunol 132: 2402, 1984

    PubMed  CAS  Google Scholar 

  168. Spitz H, Yssel H, Takelve Y, Arai N, Yokota T, Lee F, Arai KI, Banchereau J, De Vries JE: Recombinant interleukin 4 promotes growth of human T cells. J Immunol 139: 1142, 1987

    Google Scholar 

  169. Sprent J, Schaefer M, Lo D, Korngold R: Functions of purified L3T4+ and Lyt-2+ cells in vitro and in vivo. Immunol Rev 91: 195, 1986

    PubMed  CAS  Google Scholar 

  170. Sriram S, Ranges GE: Immunotherapy of autoimmune disease with T cell subset specific antibodies. In Concepts in Immuno-pathology, Vol 4, edited by Cruse JM, Lewis RE, p 275. Basel, Karger, 1987

    Google Scholar 

  171. Steiman RM, Inaba K, Schuler G, Witmer M: Stimulation of the immune response: contribution of dendritic cells. In Mechanisms of Host Resistance to Infectious Agents, Tumors, and Allografts, edited by Steiman RM, North RJ, p 71. New York, The Rockefeller Press, 1986

    Google Scholar 

  172. Swain SL, Dutton RW: Consequences of the direct interaction of helper T cells with B cells presenting antigen. Immunol Rev 99: 263, 1987

    PubMed  CAS  Google Scholar 

  173. Theofilopoulos AN, Balderas RS, Shawler DL, Lee S, Dixon FJ: Influence of the thymic genotype on the systemic lupus erythem-atosus-like disease of and T cell proliferation of MRL/lpr mice. J Exp Med 153: 1405, 1981

    PubMed  CAS  Google Scholar 

  174. Theofilopoulos AN, Dixon FJ: Murine models of systemic lupus erythematosus. Adv Immunol 37: 269, 1985

    PubMed  CAS  Google Scholar 

  175. Theofilopoulos AN, Prud’homme GJ, Dixon FJ: Autoimmune aspects of systemic lupus erythematosus. In Concepts in Immu-nopathology, Vol. 1, edited by Cruse JM, Lewis RE, p 190. Basel, Karger, 1985

    Google Scholar 

  176. Theofilopoulos AN, Prud’homme GJ, Feiser TM, Dixon FJ: B cell hyperactivity in murine lupus. I. Immunological abnormalities in lupus-prone strains and the activation of normal B cells. Immunology Today 4: 287, 1983

    Google Scholar 

  177. Theofilopoulos AN, Prud’homme GJ, Feiser TM, Dixon FJ: B cell hyperactivity in murine lupus. II. Defects in response to and production of accessory signals in lupus-prone mice. Immunology Today 4: 317, 1983

    Google Scholar 

  178. Theofilopoulos AN, Shawler DL, Eisenberg RA, Dixon FJ: Splenic immunoglobulin secreting cells and their regulation in autoimmune mice. J Exp Med 151: 446, 1980

    PubMed  CAS  Google Scholar 

  179. Trepecchio W, Maruya A, Barrett KJ: The heavy chain genes of a lupus anti-DNA autoantibody are encoded in the germ line of a nonautoimmune strain of mouse and conserved in strains of mice polymorphic for these gene locus. J Immunol 139: 3139, 1987

    Google Scholar 

  180. Tung KSK, Smith S, Matzner P, Kasai K, Oliver J, Feuchter F, Anderson R: Murine autoimmune oophoritis, epididymoorchitis and gastritis induced by day 3 thymectomy: autoantibodies. Am J Pathol 126: 303, 1987

    PubMed  CAS  Google Scholar 

  181. Tung KSK, Smith S, Teuscher C, Chester C, Anderson RE: Murine autoimmune oophoritis, epididymoorchitis, and gastritis induced by day 3 thymectomy: immunopathology. Am J Pathol 126: 293, 1987

    PubMed  CAS  Google Scholar 

  182. Tung KSK, Yule TD, Mahi-Brown CA, Listrom MB: Distribution of histopathology and la positive cells in actively induced and passively transferred experimental autoimmune orchitis. J Immunol 138: 752, 1987

    PubMed  CAS  Google Scholar 

  183. Van Eden W, Holoshitz J, Cohen I: Antigen mimicry between mycobacteria and cartilage proteoglycans. In Concepts in Immunopathology, Vol 4, edited by Cruse JM, Lewis RE, p 144. Basel, Karger, 1987

    Google Scholar 

  184. Van Rappard-van der veen FM, Kiesel U, Poels L, Schuler W, Melief CJM, Lanckgent J, Gleichman E: Further evidence against random polyclonal antibody formation in mice with lupus-like graft-vs-host disease. J Immunol 132: 1814, 1984

    Google Scholar 

  185. Vitetta ES, Bossie A, Fernandez-Botran R, Myers CD, Oliver KG, Sanders VM, Stevens TL: Interaction and activation of antigen-specific T and B cells. Immunol Rev 99: 193, 1987

    PubMed  CAS  Google Scholar 

  186. Wagner H, Hardt C, Rouse BT, Rollinghoff M, Schewich P, Pfizemaier K: Dissection of the proliferative and differentiate signals controlling murine cytotoxic T lymphocyte responses. J Exp Med 155: 1876, 1982

    PubMed  CAS  Google Scholar 

  187. Waldor MK, Sriram S, Hardy R, Herzenberg LA, Lanier L, Lim M, Steiman L: Reversal of experimental allergic encephalomyelitis with monoclonal antibody to a T-cell subset marker. Science 227: 415, 1985

    PubMed  CAS  Google Scholar 

  188. Weiss A, Imboden J, Hardy K, Manger B, Terhorst C, Stobo J: The role of the T3/antigen receptor complex in T-cell activation. Ann Rev Immunol 4: 593, 1986

    CAS  Google Scholar 

  189. Wekerle H: The lesion of acute experimental autoimmune encephalomyelitis: isolation and membrane phenotypes of lympho-vascular complexes from encephalitic rat brain white matter. Lab Invest 51: 199, 1984

    PubMed  CAS  Google Scholar 

  190. Wekerle H, Fierz W: Tlymphocyte autoimmunity in experimental autoimmune encephalomyelitis. In Concepts in Immunopathology, Vol 2, edited by Cruse JM, Lewis RE, p 102. Basel, Karger, 1985

    Google Scholar 

  191. Weston KM, Yeh ETH, Sy MS: Autoreactivity accelerates the development of autoimmunity and lymphoproliferation in MRL/ lpr mice. J immunol 139: 743, 1987

    Google Scholar 

  192. Wick G, Kite JF, Cole RK, Witebsky ES: Spontaneous autoimmune thyroiditis in the obese strain of chickens. III. The effect of bursectomy on the development of disease. J Immunol 104: 45, 1970

    PubMed  CAS  Google Scholar 

  193. Wick G, Kite JH, Witebsky E: Spontaneous thyroiditis in the obese strain of chickens IV. The effect of thymectomy and thy-mobursectomy on the development of disease. J Immunol 104: 54, 1970

    PubMed  CAS  Google Scholar 

  194. Woda BA, Handler ES, Padden C, Greiner DL, Reynolds C, Rossini AA: Anti-asialo GM1 prevents diabetes in diabetes prone but not RT6.1 depleted diabetes resistant BB rats (abstr). Diabetes 36 (Suppl 1): 39, 1987

    Google Scholar 

  195. Woda BA, Like AA, Padden C, McFadden ML: Deficiency of phenotypic cytotoxic-suppressor T lymphocytes in the BB/W rat. J Immunol 136: 856, 1986

    PubMed  CAS  Google Scholar 

  196. Wofsy D: Administration of monoclonal anti-T cell antibodies retards murine lupus in BXSB mice. J Immunol 136: 4554, 1986

    PubMed  CAS  Google Scholar 

  197. Wofsy D, Seaman WE: Reversal of advanced murine lupus in NZB/NZW Fl mice by treatment with monoclonal antibody to L3T4. J Immunol 138: 3247, 1987

    PubMed  CAS  Google Scholar 

  198. Wong GHW, Goeddel DV: Tumor necrosis factors alpha and beta inhibit replication and synergize with interferons. Nature 323: 819, 1987

    Google Scholar 

  199. Zier KS, Leo MR, Spielman RS, Baker L: Decreased synthesis of IL-2 in insulin dependent diabetes mellitus. Diabetes 33: 552, 1984

    PubMed  CAS  Google Scholar 

  200. Zubler RH, Glasebrook AL: Requirements for three signals in T- independent (lipopolysaccharide-induced) as well as T-dependent B cell responses. J Exp Med 155: 666, 1982

    PubMed  CAS  Google Scholar 

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  1. Department of Pathology, McGill University, Montreal, Canada, H3A 2B4

    Gérald J. Prud’homme & Nollaig A. Parfrey

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  1. Gérald J. Prud’homme
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  1. Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Emanuel Rubin MD (Gonzalo Aponte Professor and Chairman) & Ivan Damjanov MD (Professor) (Gonzalo Aponte Professor and Chairman) &  (Professor)

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© 1989 Humana Press · Clifton, New Jersey

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Prud’homme, G.J., Parfrey, N.A. (1989). Role of T Helper Lymphocytes in Autoimmune Diseases. In: Rubin, E., Damjanov, I. (eds) Pathology Reviews · 1989. Humana Press. https://doi.org/10.1007/978-1-4612-4502-5_7

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