Gastrin-Releasing Peptide (Mammalian Bombesin) Gene Expression in Health and Disease

  • Mary E. Sunday
  • Lee M. Kaplan
  • Etsuro Motoyama
  • William W. Chin
  • Eliot R. Spindel

Abstract

In recent years much attention has been focused on gastrin-releasing peptide (GRP), the mammalian homologue of bombesin, both as a neuroregulatory hormone and as a tissue-specific growth factor in normal and neoplastic tissues. This paper will analyze the distribution and role of GRP in normal mammalian tissues and examine the potential involvement of GRP in diverse pathologic processes.

Keywords

Dopamine Serotonin Retina Polypeptide Histamine 

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Copyright information

© Humana Press · Clifton, New Jersey 1989

Authors and Affiliations

  • Mary E. Sunday
    • 1
    • 2
    • 3
  • Lee M. Kaplan
    • 1
    • 2
  • Etsuro Motoyama
    • 1
    • 2
  • William W. Chin
    • 1
    • 2
  • Eliot R. Spindel
    • 1
    • 2
  1. 1.Departments of Pathology and MedicineBrigham & Women’s Hospital, Massachusetts General Hospital, and Harvard Medical SchoolUSA
  2. 2.Departments of Anesthesiology and PediatricsChildren’s Hospital of PittsburghUSA
  3. 3.Department of PathologyBrigham & Women’s HospitalBostonUSA

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