Transgenic Mice—A Gold Mine for Furthering Knowledge in Pathobiology

  • R. Andrew Cuthbertson
  • Gordon K. Klintworth


“Transgenic” animals, a term introduced by Gordon and Ruddle in 1981 (57), may be defined as those that have integrated foreign DNA in their somatic cells and perhaps their germ line as a consequence of the experimental introduction of DNA (151). Transgenic mice provide a means of exploring the complex molecular biologic effects of a gene in a living animal. The introduction of foreign DNA into both somatic and germ cells of mammals has made it possible to study the molecular basis of tissue-specific and stage-specific gene expression during development, and the phenotypic effects of altered gene expression.


Growth Hormone Transgenic Mouse Germ Line Genic Mouse Mouse Mammary Tumor Virus 
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Copyright information

© Humana Press · Clifton, New Jersey 1989

Authors and Affiliations

  • R. Andrew Cuthbertson
    • 1
    • 2
  • Gordon K. Klintworth
    • 1
    • 2
    • 3
  1. 1.Howard Florey Institute of Experimental Physiology and MedicineUniversity of MelbourneMelbourneAustralia
  2. 2.Departments of Pathology and OphthalmologyDuke University Medical CenterDurhamUSA
  3. 3.Department of PathologyDuke University Medical CenterDurhamUSA

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