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Transgenic Mice—A Gold Mine for Furthering Knowledge in Pathobiology

  • R. Andrew Cuthbertson
  • Gordon K. Klintworth

Abstract

“Transgenic” animals, a term introduced by Gordon and Ruddle in 1981 (57), may be defined as those that have integrated foreign DNA in their somatic cells and perhaps their germ line as a consequence of the experimental introduction of DNA (151). Transgenic mice provide a means of exploring the complex molecular biologic effects of a gene in a living animal. The introduction of foreign DNA into both somatic and germ cells of mammals has made it possible to study the molecular basis of tissue-specific and stage-specific gene expression during development, and the phenotypic effects of altered gene expression.

Keywords

Growth Hormone Transgenic Mouse Germ Line Genic Mouse Mouse Mammary Tumor Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Humana Press · Clifton, New Jersey 1989

Authors and Affiliations

  • R. Andrew Cuthbertson
    • 1
    • 2
  • Gordon K. Klintworth
    • 1
    • 2
    • 3
  1. 1.Howard Florey Institute of Experimental Physiology and MedicineUniversity of MelbourneMelbourneAustralia
  2. 2.Departments of Pathology and OphthalmologyDuke University Medical CenterDurhamUSA
  3. 3.Department of PathologyDuke University Medical CenterDurhamUSA

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