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Transgenic Mice—A Gold Mine for Furthering Knowledge in Pathobiology

  • Chapter
Pathology Reviews · 1989

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Abstract

“Transgenic” animals, a term introduced by Gordon and Ruddle in 1981 (57), may be defined as those that have integrated foreign DNA in their somatic cells and perhaps their germ line as a consequence of the experimental introduction of DNA (151). Transgenic mice provide a means of exploring the complex molecular biologic effects of a gene in a living animal. The introduction of foreign DNA into both somatic and germ cells of mammals has made it possible to study the molecular basis of tissue-specific and stage-specific gene expression during development, and the phenotypic effects of altered gene expression.

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References

  1. Adams JM, Harris AW, Langdon WY, Pinkert CA, Brinster RL, Palmiter RD, Corcoran LM, Alexander WS, Graham MW and Cory S: c-Afyc-induced lymphomagenesis in transgenic mice and the role of the Fr-1 locus in lymphoid neoplasia. Curr Trop Micro Immunol 132: 1, 1986

    CAS  Google Scholar 

  2. Adams JM, Harris AW, Pinkert CA, Corcoran LM, Alexander WS, Cory S, Palmiter RD, Brinster RL: The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 318: 533, 1985

    Article  PubMed  CAS  Google Scholar 

  3. Adams TE, Alpert S, Hanahan D: Non-tolerance and autoantibodies to a transgenic self antigen expressed in pancreatic beta cells. Nature 325: 223, 1987

    Article  PubMed  CAS  Google Scholar 

  4. Aksamit AJ, Major EO, Ghatak NR, Sidhu GS, Paraisi JE, Guccion JG: Diagnosis of progressive multifocal leukoencephalop-athy by brain biopsy with biotin labelled DNA: DNA in situ hybridization. J Neuropathol Exp Neurol 46: 556, 1987

    Article  PubMed  CAS  Google Scholar 

  5. Alt F, Blackwell TK, Yancopoulos GD: Immunoglobulin genes in transgenic mice. Trends Genet 1: 231, 1985

    Article  CAS  Google Scholar 

  6. Anderson WF: Prospects for human gene therapy. Science 226: 401, 1984

    Article  PubMed  CAS  Google Scholar 

  7. Andres A-C, Schonenberger C-A, Groner B, Henninghausen L, LeMeur M, Gerlinger P: Ha-ras oncogene expression directed by a milk protein gene promotion tissue specificity, hormonal regulation, and tumor induction in transgenic mice. Proc Natl Acad Sci USA 84: 1299, 1987

    Article  PubMed  CAS  Google Scholar 

  8. Babinet C, Farza H, Morello D, Hadchouel M, Pourcel C: Specific expression of hepatitis B surface antigen (HBsAg) in transgenic mice. Science 230: 1160, 1985

    Article  PubMed  CAS  Google Scholar 

  9. Beamer WG, Eicher EM: Stimulation of growth in the little mouse. J Endocrinol 71: 37, 1976

    Article  PubMed  CAS  Google Scholar 

  10. Benoist C, Gerlinger P, LeMeur M, Mathis D: Transgenic mice: new wave immunogenetics. Immunology Today 7: 138, 1986

    Article  CAS  Google Scholar 

  11. Bieberich C, Scangos G: Transgenic mice in the study of immunology. Bioassays 4: 245, 1986

    Article  CAS  Google Scholar 

  12. Bieberich C Scangos G, Tanaka K, Jay G: Regulated expression of a murine class I gene in transgenic mice. Ann NY Acad Sci 478:255, 1986

    Google Scholar 

  13. Botteri FM, van der Putten H, Miller AD, Fran H, Verma IM: Recombinant retroviruses in transgenic mice. Ann NY Acad Sci 478: 255, 1986

    Article  PubMed  CAS  Google Scholar 

  14. Botteri FM, van der Putten H, Wong DF, Sauvage CA, Evans RM: Unexpected thymic hyperplasia in transgenic mice harboring a neuronal promoter fused with simian virus 40 large T antigen. Mol Cell Biol 7: 3178, 1987

    PubMed  CAS  Google Scholar 

  15. Bradley A, Evans M, Kaufman MH, Robertson E: Formation of germ-line chimera from embryo-derived teratocarcinoma cells. Nature 309: 255, 1984

    Article  PubMed  CAS  Google Scholar 

  16. Breitman ML, Clapoff S, Rossant J, Tsui L-C, Glode LM, Maxwell IH, Bernstein A: Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science 238: 1563, 1987

    Article  PubMed  CAS  Google Scholar 

  17. Brinster RL, Chen HY, Messing A, Van Dyke T, Levine AJ, Palmiter RD: Transgenic mice harboring SV40 T-antigen genes develop characteristic brain tumors. Cell 327: 367, 1984

    Article  Google Scholar 

  18. Brinster RL, Chen HY, Trumbauer ME, Avarbock MR: Translation of globin messenger RNA by the mouse ovum. Nature 283: 499, 1980

    Article  PubMed  CAS  Google Scholar 

  19. Brinster RL, Chen HY, Trumbauer ME, Senear AW, Warren R, Palmiter RD: Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 277: 223, 1981

    Article  Google Scholar 

  20. Brinster RL, Chen HY, Trumbauer ME, Yagle MK, Palmiter RD: Factors affecting the efficiency of introducing foreign DNA into mice by microinjecting eggs. Proc Natl Acad Sci USA 84: 4438, 1985

    Article  Google Scholar 

  21. Brinster RL, Chen HY, Warren R, Sarthy A, Palmiter RD: Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature 296: 39, 1982

    Article  PubMed  CAS  Google Scholar 

  22. Brinster RL, Palmiter RD: Production of tumors following the introduction of T-antigen genes into mice. In Genetic Manipulation of the Mammalian Ovum and Early Embryo, edited by Costantini F, Jaenisch R, New York, Cold Spring Harbor Laboratory Press, 1985

    Google Scholar 

  23. Brinster RL, Richie KA, Hammer RE, O’Brien RL, Arp B, Storb U: Expression of a microinjected immunoglobulin gene in the spleen of transgenic mice. Nature 306: 332, 1983

    Article  PubMed  CAS  Google Scholar 

  24. Bucchini D, Reynaud CA, Ripoche MA, Grimal H, Jami J, Weill JC: Rearrangement of a chicken immunoglobulin gene occurs in the lymphoid lineage of transgenic mice. Nature 326: 409, 1987

    Article  PubMed  CAS  Google Scholar 

  25. Bucchini D, Ripoche MA, Stinnakre MG, Desbois P, Lores P, Monthioux E, Absil J, Lepesant JA, Pictet R, Jami J: Pancreatic expression of human insulin gene in transgenic mice. Proc Natl Acad Sci USA 83: 2511, 1986

    Article  PubMed  CAS  Google Scholar 

  26. Burki K, Ullrich A: High efficiency transformation of the human insulin gene into fertilized mouse eggs. EMBO J 1: 127, 1982

    PubMed  CAS  Google Scholar 

  27. Buttin G: Exogenous Ig gene rearrangement in transgenic mice: a new strategy for human monoclonal antibody production? Trends Genet 3: 205, 1987

    Article  CAS  Google Scholar 

  28. Chada K, Magram J, Costantini F: An embryonic pattern of expression of a human fetal globin gene in transgenic mice. Nature 319: 685, 1986

    Article  PubMed  CAS  Google Scholar 

  29. Chada K, Magram J, Raphael K, Radice G, Lacy E, Costantini F: Specific expression of a foreign beta-globin gene in erythroid cells of transgenic mice. Nature 314: 377, 1985

    Article  PubMed  CAS  Google Scholar 

  30. Chen CW, Thomas CA Jr: Recovery of DNA segments from agarose gels. Anal Biochem 101: 339, 1980

    Article  PubMed  CAS  Google Scholar 

  31. Chen S, Botteri F, Van der Putten H, Landel CP, Evans GA: A lymphoproliferative abnormality associated with inappropriate expression of the Thy-1 antigen in transgenic mice. Cell 51: 7, 1987.

    Article  PubMed  CAS  Google Scholar 

  32. Chisari FV, Pinkert CA, Millich DR, Filippi P, McLachlan A, Palmiter RD, Brinster RL: A transgenic mouse model of the chronic hepatitis B surface antigen carrier state. Science 6:1157,1985

    Article  Google Scholar 

  33. Choo KH, Raphael K, McAdam W, Peterson MG: Expression of active human blood clotting factor IX in transgenic mice: use of a cDNA with complete mRNA sequence. Nucleic Acids Res 15: 871, 1987

    Article  PubMed  CAS  Google Scholar 

  34. Corcoran LM, Cory S and Adams JM: Transposition of the immunoglobin heavy chain enhancer to the myc oncogene in a murine plasmacytoma. Cell 40: 71, 1985

    Article  PubMed  CAS  Google Scholar 

  35. Costantini F, Chada K, Magram J: Correction of murine thalassemia by gene transfer into the germ line. Science 233:1192,1986

    Article  PubMed  CAS  Google Scholar 

  36. Costantini F, Lacy E: Introduction of a rabbit 0-globulin gene into the mouse germ line. Nature 294: 92, 1981

    Article  PubMed  CAS  Google Scholar 

  37. Costantini F, Radice G, Magram J, Stamatoyannopoulos G, Pa-payannopoulou T, Chada K: Developmental regulation of human globin genes in transgenic mice. Cold Spring Harbor Symp Quant Biol 50: 361, 1985

    PubMed  CAS  Google Scholar 

  38. Covarrubias L, Nishida Y, Mintz B: Early postimplantation embryo lethality due to DNA rearrangements in a transgenic mouse strain. Proc Natl Acad Sci USA 83: 6020, 1986

    Article  PubMed  CAS  Google Scholar 

  39. Covarrubias L, Nishida Y, Terao M, D’Eustachio P, Mintz B: Cellular DNA rearrangements and early developmental arrest caused by DNA insertion in transgenic mouse embryos. Mol Cell Biol 7: 2243, 1987

    PubMed  CAS  Google Scholar 

  40. Crenshaw EB III, Russo AF, Swanson LW, Rosenfeld MG: Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene. Cell 49: 389, 1987

    Article  PubMed  CAS  Google Scholar 

  41. Durnam DM, Hoffman JS, Quaife CJ, Benditt EP, Chen HY, Brinster RL, Palmiter RD: Induction of mouse metallothionein- 1 mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones. Proc Natl Acad Sci USA 81: 1053, 1984

    Article  PubMed  CAS  Google Scholar 

  42. Efrat S, Baekkeahor S, Lane D, Hanahan D. Coordinate expression of the endogenous p53 gene in ß cells of transgenic mice expressing hybrid insulin-SV40 transgenic genes. EMBO J 6: 2699, 1987

    PubMed  CAS  Google Scholar 

  43. Eichholtz DA, Rogers SG, Horsch RB, Klee HJ, Hayford M, Hoffman NL, Braford SB, Fink C, Flick J, O’Connell KM, Fraley RT: Expression of mouse dihydrofolate reductase gene confers methotrexate resistance in transgenic petunia plants. Somatic Cell Mol Genet 13: 67, 1987

    Article  CAS  Google Scholar 

  44. Evans MJ, Kaufman MH: Establishment on culture of pluripo-tential cells from mouse embryos. Nature 292: 154, 1981

    Article  PubMed  CAS  Google Scholar 

  45. Evans RM, Swanson L, Rosenfeld MG: Creation of transgenic animals to study development and as models of human disease. Recent Progr Hormone Res 41: 317, 1985

    PubMed  CAS  Google Scholar 

  46. Faas SJ, Pan S, Pinkert CA, Brinster RL, Knowles BB: Simian virus 40 (SV40)-transgenic mice that develop tumors are specifically tolerant to SV40 T antigen. J Exp Med 165: 417, 1987

    Article  PubMed  CAS  Google Scholar 

  47. Farza H, Salmon AM, Hadchouel M, Moreau JL, Babinet C, Tiollais P, Pourcel C: Hepatitis B surface antigen gene expression is regulated by sex steroids and glucocorticoids in transgenic mice. Proc Natl Acad Sci USA 84: 1187, 1987

    Article  PubMed  CAS  Google Scholar 

  48. Field LJ: Atrail natriuretic factor-SV40 T antigen transgenes produce tumors and cardiac arrhythmias in mice. Science 239: 1029, 1988

    Article  PubMed  CAS  Google Scholar 

  49. Fischoff DA, Bowdish KS, Perlak FJ, Marrone PG, McCormick SM, Niedermeyer JG, Dean DA, Kusano-Kretzmer K, Mayer EJ, Rochester DE, Rogers SG, Fraley RT: Insect tolerant transgenic tomatoe plants. Biotechnology 5: 807, 1987

    Article  Google Scholar 

  50. Forsthoefel PF: Genetics and manifold effects of Strong’s luxoid gene in the mouse, including its interactions with Greens’ luxoid and Carter’s luxate genes. J Morphol 110: 391, 1962

    Article  PubMed  CAS  Google Scholar 

  51. Frels WI, Bluestone JA, Hodes RJ, Capecchi MR, Singer DS: Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice. Science 228: 577, 1985

    Article  PubMed  CAS  Google Scholar 

  52. Gartler SM, Riggs AD: Mammalian X-chromosome inactivation. Annu Rev Genet 17: 155, 1983

    Article  PubMed  CAS  Google Scholar 

  53. Gehring WJ: Homeoboxes in the study of development. Science 236: 1245, 1987

    Article  PubMed  CAS  Google Scholar 

  54. Gerlinger P, LeMeur M, Irrmann C, Renard P, Wasylyk C, Wasylyk B: B-lymphocyte targeting of gene expression in transgenic mice with the immunoglobulin heavy-chain enhancer. Nucleic Acids Res 14: 6565, 1986

    Article  PubMed  CAS  Google Scholar 

  55. Goldman MA, Stokes KR, Idzerda RL, McKnight GS, Hammer RE, Brinster RL, Gartler SM: A chicken transferrin gene in transgenic mice escapes X-chromosome inactivation. Science 236: 593, 1987

    Article  PubMed  CAS  Google Scholar 

  56. Gordon JW: A foreign dihydrofolate reductase gene in transgenic mice acts as a dominant mutation. Mol Cell Biol 6: 2158, 1986

    PubMed  CAS  Google Scholar 

  57. Gordon JW, Chesa PG, Nishimura H, Rettig WJ, Maccari JE, Endo T, Seravalli E, Seki T, Silver J: Regulation of Thy-1 gene expression in transgenic mice. Cell 50: 445, 1987

    Article  PubMed  CAS  Google Scholar 

  58. Gordon JW, Ruddle RH: Integration and stable germ line transmission of genes injected into mouse pronuclei. Science 214: 1244, 1981

    Article  PubMed  CAS  Google Scholar 

  59. Gordon JW, Ruddle RH: Gene transfer into mouse embryos: production of transgenic mice by pronuclear injection. Methods Enzymol 101: 411, 1983

    Article  PubMed  CAS  Google Scholar 

  60. Gordon JW, Ruddle RH: DNA-mediated genetic transformation of mouse embryos and bone marrow—a review. Gene 33: 121, 1985

    Article  PubMed  CAS  Google Scholar 

  61. Gordon JW, Scangos GA, Plotkin DJ, Barbosa JA, Ruddle RH: Genetic transformation of mouse embryos by microinjection of purified DNA. Proc Natl Acad Sci USA 77: 7380, 1980

    Article  PubMed  CAS  Google Scholar 

  62. Goring DR, Rossant J, Clapoff S, Breitman ML, Tsui L-C: In situ detection of beta-galactosidase in lenses of transgenic mice with a gamma-crystallin/lac Z gene. Science 235: 456, 1987

    Article  PubMed  CAS  Google Scholar 

  63. Graves JAM: 5-Azactyidine induced re-expression of alleles on the inactivate X-chromosome in a hybrid mouse cell line. Exp Cell Res 141:99,1982

    Google Scholar 

  64. Green MC: Mutant genes and linkages. In Biology of the Laboratory Mouse, Ed 2, edited by Green EL, pp 87–150. New York, McGraw Hill, 1966

    Google Scholar 

  65. Grosschedl R, Weaver D, Baltimore D, Costantini F: Introduction of mu immunoglobulin gene into the mouse germ line: specific expression in lymphoid cells and synthesis of functional antibody. Cell 38: 647, 1984

    Article  PubMed  CAS  Google Scholar 

  66. Gurdon JB, Melton DA: Gene transfer in amphibian eggs and oocytes. Ann Rev Genet 15: 189, 1981

    Article  PubMed  CAS  Google Scholar 

  67. Hammer RE, Brinster RL, Palmiter RD: Use of gene transfer to increase animal growth. Cold Spring Harbor Symp Quant Biol 50: 379, 1985

    PubMed  CAS  Google Scholar 

  68. Hammer RE, Brinster RL, Rosenfeld MG, Evans RM, Mayo KE: Expression of human growth hormone-releasing factor in transgenic mice results in increased somatic growth. Nature 315: 413, 1985

    Article  PubMed  CAS  Google Scholar 

  69. Hammer RE, Idzerda RL, Brinster RL, McKnight S: Estrogen regulation of the avian transferrin gene in transgenic mice. Mol Cell Biol 6: 1010, 1986

    PubMed  CAS  Google Scholar 

  70. Hammer RE, Palmiter RD, Brinster RL: Partial correction of murine hereditary growth disorder by germ-line incorporation of a new gene. Nature 311: 65, 1984

    Article  PubMed  CAS  Google Scholar 

  71. Hammer RE, Pursel VG, Rexroad CE Jr, Wall RJ, Bolt DJ, Ebert KM, Palmiter RD, Brinster RL: Production of transgenic rabbits, sheep and pigs by microinjection. Nature 315: 680, 1985

    Article  PubMed  CAS  Google Scholar 

  72. Hammer RE, Pursel VG, Rexroad CE Jr, Wall RJ, Bolt DJ, Palmiter RD, Brinster RL: Genetic engineering of mammalian embryos. J Anim Sci 63: 269, 1986

    PubMed  CAS  Google Scholar 

  73. Hammer RE, Swift GH, Ornitz DM, Quaife CJ, Palmiter RD, Brinster RL, MacDonald RJ: The rat elastase-I regulatory element is an enhancer that directs correct cell specificity and developmental onset of expression in transgenic mice. Mol Cell Biol 7: 2956, 1987

    PubMed  CAS  Google Scholar 

  74. Hanahan D: Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes. Nature 315: 115, 1985

    Article  PubMed  CAS  Google Scholar 

  75. Hanahan D: Oncogenesis in transgenic mice. In Oncogenes and Growth Control, edited by Graf, T, Kahn P, pp 349–363. Heidelberg, Springer-Verlag, 1986

    Google Scholar 

  76. Harbers K, Kuehn M, Delius H, Jaenisch R: Insertion of retrovirus into the first intron of a a collagen gene leads to embryonic lethal mutation in mice. Proc Natl Acad Sci USA 81: 1504, 1984

    Article  PubMed  CAS  Google Scholar 

  77. Herzenberg LA, Stall AM, Braun J, Weaver D, Baltimore D, Herzenberg LA, Grosschecll R: Depletion of the predominant B- cell population in immunoglobulin p heavy chain transgenic mice. Nature 329: 71, 1987

    Article  PubMed  CAS  Google Scholar 

  78. Hinrichs SH, Nerenberg M, Reynolds PK, Khoury G, Jay G: A transgenic mouse model for human neurofibromatosis. Science 237: 1340, 1987

    Article  PubMed  CAS  Google Scholar 

  79. Hock RA, Miller AD: Retrovirus-mediated transfer and expression of drug resistance genes in human haematopoietic progenitor cells. Nature (London) 320: 275, 1986

    Article  CAS  Google Scholar 

  80. Hogan BLM, Costantini F, Lacy E: Manipulation of the Mouse Embryo: A Laboratory Manual. New York, Cold Spring Harbor Laboratory Press, 1986

    Google Scholar 

  81. Hooper M, Hardy K, Handyside A, Hunter S, Monk M: HPRT- deficient (Lesch-Nyhan) mouse embryos derived from germline colonization by cultured cells. Nature 326: 292, 1987

    Article  PubMed  CAS  Google Scholar 

  82. Hoppe PC, Illmensee K: Microsurgically produced homozygous-diploid uniparental mice. Proc Natl Acad Sci USA 74: 5657, 1977

    Article  PubMed  CAS  Google Scholar 

  83. Hudson P, Penschow J, Shine J, Ryan G, Niall H, Coghlan J: Hybridization histochemistry: Use of recombinant DNA as a “homing probe” for tissue localization of specific mRNA populations. Endocrinology 108: 353, 1981

    Article  PubMed  CAS  Google Scholar 

  84. Humphries RK, Berg P, DiPietro J, Bernstein S, Baur A, Nienhuis AW, Anderson WF: Transfer of human and murine globin-gene sequences into transgenic mice. Am J Hum Genet 37: 295, 1985

    PubMed  CAS  Google Scholar 

  85. Huszar D, Balling R, Kothary R, Magli MC, Hozumi N, Rossant, J, Bernstein A: Insertion of a bacterial gene into the mouse germ line using an infectious retrovirus vector. Proc Natl Acad Sci USA 82: 8587, 1985

    Article  PubMed  CAS  Google Scholar 

  86. Isobe K, Kollias G, Kolsto AB, Grosveld F: T cell independent Thy-1 alloantibody response with the use of transgenic mice. J Immunol 137: 2089, 1986

    PubMed  CAS  Google Scholar 

  87. Isola LM, Gordon JW: Systemic resistance to methotrexate in transgenic mice carrying a mutant dihydrofolate reductase gene. Proc Natl Acad Sci USA 83: 9621, 1986

    Article  PubMed  CAS  Google Scholar 

  88. Izant JE, Weintraub H.: Constitutive and conditional suppression of exogenous and endogenous genes by anti-sense RNA. Science 229: 345, 1985

    Article  PubMed  CAS  Google Scholar 

  89. Jaenisch R: Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci USA 73: 1260, 1976

    Article  PubMed  CAS  Google Scholar 

  90. Jaenisch R, Harbers K, Schnieke A, Lohler J, Chumakov I, Jahner D, Grotkopp D, Hoffman E.: Germline integration of Moloney murine leukemia virus at the Mov 13 locus leads to recessive lethal mutation and early embryonic death. Cell 32: 209, 1983

    Article  PubMed  CAS  Google Scholar 

  91. Jaenisch R, Jahner D, Nobis P, Simon T, Lohler J, Harbers K, Grotkopp D: Chromosomal position and advance of retroviral genomes inserted into germ line of mice. Cell 24: 519, 1981

    Article  PubMed  CAS  Google Scholar 

  92. Jaenisch R, Mintz B: Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sci USA 71: 1250, 1974

    Article  PubMed  CAS  Google Scholar 

  93. Jahner D, Haase K, Mulligan R, Jaenisch R: Insertion of the bacterial gpt gene into the germ of mice by retroviral infection. Proc Natl Acad Sci USA 82: 6927, 1985

    Article  PubMed  CAS  Google Scholar 

  94. Jenkins NA, Copeland NG, Taylor BA, Lee BK: Dilute (d) coat color mutation of DBA/2J mice is associated with the site of integration of an ectroopic MuLV genome. Nature 293: 370, 1981

    Article  PubMed  CAS  Google Scholar 

  95. Johnson RT: Evidence for polyomaviruses in human neurological diseases. In Polyomaviruses and Human Neurological Disease: Proceedings of a Conference held at the Fogarty International Center, National Institutes of Health, Bethesda Maryland, June 14–16, 1982, edited by Sever JL, Madden DL, p 183. New York, Alan R. Liss, 1983

    Google Scholar 

  96. Kafatos FC, Jones WC, Efstratiadis A: Determination of nucleic acid sequence homologies and relative concentrations by a dot hybridization procedure. Nucleic Acids Res 7: 1541, 1979

    Article  PubMed  CAS  Google Scholar 

  97. Kagi JHR, Nordberg M (Editors:) Metallothionein, Birhauser Verlag, Basel, 1979

    Google Scholar 

  98. Keith DH, Singer-Sam J, Riggs AD: Active X-chromosome DNA is unmethylated at eight CCGG sites clustered in a guanine-plus-cytosine-rich island at the 5’ end of the gene for phosphoglycerate kinase. Mol Cell Biol 6: 4122, 1986

    PubMed  CAS  Google Scholar 

  99. Khillan JS, Oskarsson MK, Propst F, Kuwabara T, Vande Woude GF, Westphal H: Defects in lens fiber differentiation are linked to c-mos overexpression in transgenic mice. Gene Dev 1: 1327, 1987

    Article  PubMed  CAS  Google Scholar 

  100. Khillan JS, Overbeek PA, Westphal H: Drosophila P element integration in the mouse. Dev Biol 109: 247, 1985

    Article  PubMed  CAS  Google Scholar 

  101. Khillan JS, Schmidt A, Overbeek PA, de Crombrugghe B, Westphal H: Developmental and tissue-specific expression directed by the alpha2 type 1 collagen promoter in transgenic mice. Proc Natl Acad Sci USA 83: 725, 1986.

    Article  PubMed  CAS  Google Scholar 

  102. Kollias G, Evans DJ, Ritter M, Beech J, Morris R, Grosveld F: Ectopic expression of Thy-1 in the kidneys of transgenic mice induce functional and proliferative abnormalities. Cell 51: 21, 1987

    Article  PubMed  CAS  Google Scholar 

  103. Kollias G, Wrighton N, Hurst J, Grosveld F: Regulated expression of human A gamma-, beta-, and hybrid gamma beta-globulin genes in transgenic mice: manipulation of gamma developmental expression patterns. Cell 46: 89, 1986

    Article  PubMed  CAS  Google Scholar 

  104. Kondoh H, Katoh K, Takahashi Y, Fujisawa H, Yokoyama M, Kimura S, Katsuki M, Saito M, Nomura T, Hiramoto Y, Okada TS: Specific expression of the chicken 6-crystallin gene in the lens and the pyramidal neurons of the piriform cortex in transgenic mice. Dev Biol 120: 177, 1987

    Article  PubMed  CAS  Google Scholar 

  105. Kostyo JL, Isaksson O: Growth hormone and the regulation of somatic growth. Int Rev Physiol 13: 255, 1977

    PubMed  CAS  Google Scholar 

  106. Krumlauf R, Chapman VM, Hammer RE, Brinster RL, Tilghman SM: Differential expression of alpha-fetoprotein genes on the inactive X chromosome in extraembyronic and somatic tissues of a transgenic mouse line. Nature 319: 224, 1986

    Article  PubMed  CAS  Google Scholar 

  107. Krumlauf R, Hammer RE, Tilghmam SM, Brinster RL: Developmental regulation of alpha-fetoprotein genes in transgenic mice. Mol Cell Biol 5: 1639, 1985

    PubMed  CAS  Google Scholar 

  108. Kuehn MR, Bradley A, Robertson EJ, Evans MJ: A potential animal model for Lesch-Nyhan syndrome through introduction of HPRT mutations into mice. Nature 326: 295, 1987

    Article  PubMed  CAS  Google Scholar 

  109. Lacy M, Alpert S, Hanahan D: Bovine papillomavirus genome elicits skin tumors in transgenic mice. Nature 322: 609, 1986

    Article  Google Scholar 

  110. Lacy E, Costantini FD: Structure and expression of foreign globin genes in transgenic mice. Prog Clin Biol Res 134: 13, 1983

    PubMed  CAS  Google Scholar 

  111. Lacy E, Roberts S, Evans EP, Burtenshaw MD, Costantini RE: A foreign beta-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues. Cell 34: 343, 1983

    Article  PubMed  CAS  Google Scholar 

  112. Lang RA, Metealf D, Cuthbertson RA, Lyons I, Stanley E, Kelso A, Kannourakis G, Williamson J, Klintworth GK, Gonda TJ, Dunn AR: Transgenic mice expressing a hemopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness and a fatal syndrome of tissue damage. Cell 51: 675, 1987

    Article  PubMed  CAS  Google Scholar 

  113. Langdon WY, Harris AW, Cory S, Adams JM: The c-myc oncogene perturbs B lymphocyte development in Eß-myc transgenic mice. Cell 47: 11, 1986

    Article  PubMed  CAS  Google Scholar 

  114. Leder A, Pattengale PK, Kuo A, Stewart TA, Leder P: Consequences of widespread deregulation of the c-myc gene in transgenic mice: multiple neoplasms and normal development. Cell 23: 485, 1986

    Article  Google Scholar 

  115. Le Meur M, Gerlinger P, Benoist C, Mathis D: Correcting an immune-response deficiency by creating E alpha gene transgenic mice. Nature 316: 38, 1985

    Google Scholar 

  116. Leopold P, Vailly J, Cuzin F, Rassoulzadegan M: Maintenance of autonomous genetic elements in twelve transgenic mouse strains established after transfer of pPyLTl DNA. Biochem Biophys Res Commun 141: 1162, 1986

    Article  PubMed  CAS  Google Scholar 

  117. Lester SC, Korn NJ, DeMars R: Derepression of genes on the human inactive X chromosome: evidence for differences in locus-specific rates of derepression and rates of transfer of active and inactive genes after DNA-mediated transformation. Somatic Cell Genet 8: 265, 1982

    Article  PubMed  CAS  Google Scholar 

  118. Lewin B: Genes III, Ed 3, New York, John Wiley & Sons, 1987

    Google Scholar 

  119. Lock LF, Melton DW, Caskey CT, Martin GR: Methylation of the mouse hprt gene differs on the active and inactive chromosomes. Mol Cell Biol 6: 914, 1986

    PubMed  CAS  Google Scholar 

  120. Loesch-Fries LS, Merlo D, Zinnen T, Burhop L, Hill K, Krahn K, Jarvis N, Nelson S, Halk E: Expression of alfalfa mosaic virus RNA 4 in transgenic plants confers virus resistance. EMBO J 6: 1845, 1987

    PubMed  CAS  Google Scholar 

  121. Low MJ, Hammer RE, Goodman RH, Habener JF, Palmiter RD, Brinster RL: Tissue-specific post-translational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell 41: 211, 1985

    Article  PubMed  CAS  Google Scholar 

  122. Low MJ, Lechan RM, Hammer RE, Bristner RL, Habener JF, Mandel G, Goodman RH: Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science 231: 1002, 1986

    Article  PubMed  CAS  Google Scholar 

  123. Low MJ, Stork PJ, Hammer RE, Brinster RL, Warhol MJ, Mandel G, Goodman RH: Somatostatin is targeted to the regulated secretory pathway of gonadotrophs in transgenic mice expressing a metallothionein-somatostatin gene. J Biol Chem 261: 6260, 1986

    Google Scholar 

  124. Low PA, McCloud JG: Hereditary demyelinating neuropathy in the trembler mouse. J Neurol Sei 26: 565, 1975

    Article  CAS  Google Scholar 

  125. MacDonald RJ, Hammer RE, Swift GH, Davis BP, Brinster RL: Transgenic progeny inherit tissue-specific expression of rat elas-tase I genes. DNA 5: 393, 1986

    Article  PubMed  CAS  Google Scholar 

  126. Magram J, Chada K, Costantini F: Development regulation of a cloned adult beta-globin gene in transgenic mice. Nature 315: 338, 1985

    Article  PubMed  CAS  Google Scholar 

  127. Mahon KA, Chepelinsky AB, Khillan JS, Overbeek PA, Piatigorsky J, Westphal H: Oncogenesis of the lens in transgenic mice. Science 235: 1622, 1987

    Article  PubMed  CAS  Google Scholar 

  128. Maniatis T, Fritsch EF, Sambrook J: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1982

    Google Scholar 

  129. Maniatis T, Goodbourn S, Fischer JA: Regulation of inducible and tissue-specific gene expression. Science 236: 1237, 1987

    Article  PubMed  CAS  Google Scholar 

  130. Mark WH, Signorelli K, Lacy E: An insertional mutation in a transgenic mouse line results in developmental arrest at day 5 of gestation. Cold Spring Harbor Symp Quant Biol 50: 453, 1985

    PubMed  CAS  Google Scholar 

  131. Mason AJ, Hayflick JS, Zoeller RT, Young WS III, Phillips HS, Nikolics K, Seeburg PH: A deletion truncating the gonadotropin-releasing hormone gene is responsible for hypogonadism in the hpg mouse. Science 234: 1366, 1987

    Article  Google Scholar 

  132. Mason AJ, Pitts SL, Nikolics K, Szonyi, Wilson JN, Seeburg PH, Stewart TA: The hypogonadal mouse: reproductive functions restored by gene therapy. Science 234: 1372, 1986

    Article  PubMed  CAS  Google Scholar 

  133. Matsunaga T, Cabilly-Horesh O, Terz D, Lee A, Chirstian L, Ohno S, Biro AP: Use of transgenic mice with human MHC class 1 gene (HLA-A2). Adv Exp Med Biol 186: 341, 1985

    PubMed  CAS  Google Scholar 

  134. McGrath J, Solter D: Nuclear transplantation in the mouse embryo by microsurgery and cell fusion. Science 220: 1300, 1983

    Article  PubMed  CAS  Google Scholar 

  135. McKnight GS: The induction of ovalbumin and conalbumin mRNA by estrogen and progesterone in chick oviduct explant cultures. Cell 14: 403, 1978

    Article  PubMed  CAS  Google Scholar 

  136. McKnight GS, Hammer RE, Kuenzel EA, Brinster RL: Expression of the chicken transferrin gene in transgenic mice. Cell 34: 335, 1983

    Article  PubMed  CAS  Google Scholar 

  137. Messing A, Chen HY, Palmiter RD, Brinster RL: Peripheral neuropathies, hepatocellular carcinomas and islet cell adenomas in transgenic mice. Nature 316: 461, 1985

    Article  PubMed  CAS  Google Scholar 

  138. Mintz B, Cronmiller C: METT-1: a karyotypically normal in vitro line of developmentally totipotent mouse teratocarcinoma cells. Som Cell Genet 7: 485, 1981

    Article  Google Scholar 

  139. Mintz B, Illmensee K: Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci USA 72: 3585, 1975

    Article  PubMed  CAS  Google Scholar 

  140. Mohandas T, Sparkes RS, Shapiro LJ: Reactivation of an inactive human X chromosomes: evidence of X inactivation by DNA methylation. Science 211: 393, 1981

    Article  PubMed  CAS  Google Scholar 

  141. Morello D, Moore G, Salmon AM, Yaniv M, Babinet C: Studies on the expression of an H-2K/human growth hormone fusion gene in giant transgenic mice. EMBO J 5: 1877, 1986

    PubMed  CAS  Google Scholar 

  142. Nerenberg M, Hinrichs SH, Reynolds RK, Khoury G, Jay G: The tat gene of human T-lymphotropic virus type I induces mesenchymal tumors in transgenic mice. Science 237: 1324, 1987

    Article  PubMed  CAS  Google Scholar 

  143. Norstedt G, Palmiter RD: Secretory rhythm of growth hormone regulates sexual differentiation of mouse liver. Cell 36: 805, 1984

    Article  PubMed  CAS  Google Scholar 

  144. Nussenzweig MC, Shaw AC, Sinn E, Danner DB, Holmes KL, Morse HC 3d, Leder P: Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin mu. Science 236: 816, 1987

    Article  PubMed  CAS  Google Scholar 

  145. O’Brien RL, Brinster RL, Storb U: Somatic hypermutation of an immunoglobulin transgene in kappa transgenic mice. Nature 326: 405, 1987

    Article  PubMed  Google Scholar 

  146. Ornitz DM, Hammer RE, Messing A, Palmiter RD, Brinster RL: Pancreatic neoplasia induced by SV40 T-antigen expression in acinar cells of transgenic mice. Science 238: 188, 1987

    Article  PubMed  CAS  Google Scholar 

  147. Ornitz DM, Palmiter RD, Hammer RE, Brinster RL, Swift GH, MacDonald RJ: Specific expression of an elastase-human growth hormone fusion gene in pancreatic acinar cells of transgenic mice. Nature 313: 600, 1985

    Article  PubMed  CAS  Google Scholar 

  148. Ornitz DM, Palmiter RD, Messing A, Hammer RE, Pinkert CA, Brinster RL: Elastase I promoter directs expression of human growth hormone and SV40 T-antigen genes to pancreatic acinar cells in transgenic mice. Cold Spring Harbor Symp Quant Biol 50: 399, 1985

    PubMed  CAS  Google Scholar 

  149. Overbeek PA, Chepelinsky AB, Khillan JS, Piatigorsky J, Westphal H: Lens-specific expression and developmental regulation of the bacterial chloramphenicol acetyltransferase gene driven by the murine alpha A-crystallin promoter in transgenic mice. Proc Natl Acad Sci USA 82: 7815, 1985

    Article  PubMed  CAS  Google Scholar 

  150. Overbeek OA, Lai SP, Van Quill KR, Westphal H: Tissue-specific expression in transgenic mice of a fused gene containing RSV terminal sequences. Science 231: 1574, 1986

    Article  PubMed  CAS  Google Scholar 

  151. Palmiter RD: Molecular biology of metallothionein gene expression. In Metallothionein II: Proceedings of the Second International Meeting on Metallothionein and Other Low Molecular Weight Usual-Binding Proteins, edited by Kagi JHK, Kojima, Y, Basel Birkhauser-Verlag, 1987

    Google Scholar 

  152. Palmiter RD, Behringer RR, Quaife CJ, Maxwell F, Maxwell IH, Brinster RL: Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 50: 435, 1987

    Article  PubMed  CAS  Google Scholar 

  153. Palmiter RD, Brinster RL: Transgenic mice. Cell 41: 343, 1985

    Article  PubMed  CAS  Google Scholar 

  154. Palmiter RD, Brinster RL: Germ line transformation of mice. Ann Rev Genet 20: 465, 1986

    Article  PubMed  CAS  Google Scholar 

  155. Palmiter RD, Brinster RL, Hammer RE, Trumbauer ME, Rosen-feld MG, Birnberg NC, Evans RM: Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300: 611, 1982

    Article  PubMed  CAS  Google Scholar 

  156. Palmiter RD, Chen HY, Brinster RL: Differential regulation of metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell 29: 701, 1982

    Article  PubMed  CAS  Google Scholar 

  157. Palmiter RD, Chen HY, Messing A, Brinster RL: SV40 enhancer and large-T antigen are instrumental in development of choroid plexus tumours in transgenic mice. Nature 316: 457, 1985

    Article  PubMed  CAS  Google Scholar 

  158. Palmiter RD, Norstedt G, Gelinas RE, Hammer RE, Brinster RL: Metallothionein-human GH fusion genes stimulate growth of mice. Science 222: 809, 1983

    Article  PubMed  CAS  Google Scholar 

  159. Payvar F, DeFranco D, Firestone G, Edgar B, Wränge O, Okret S, Gustafsson JA, Yamamoto KR: Sequence specific binding of glucocorticoid receptor of MTV DNA at sites within and upstream of the transcribed region. Cell 35: 381, 1983

    Article  PubMed  CAS  Google Scholar 

  160. Penschow JD, Haralambidis J, Aldred P, Tregear GW, Coghlan JP: Localization of gene expression in CNS using hybridization histochemistry. Methods Enzymol 124: 534, 1986

    Article  PubMed  CAS  Google Scholar 

  161. Peschon JJ, Behringer RR, Brinster RL, Palmiter RD: Spermatid-specific expression of protamine 1 in transgenic mice. Proc Natl Acad Sei USA 84: 5316, 1987

    Article  CAS  Google Scholar 

  162. Piatigorsky J: Lens crystallins and their gene families. Cell 38: 620, 1984

    Article  PubMed  CAS  Google Scholar 

  163. Pinkert CA, Widera G, Cowing C, Heber-Katz E, Palmiter RD, Flavell RD, Brinster RL: Tissue-specific inducible and functional expression of the E alpha d MHC class II gene in trangenic mice. EMBO J 4: 2225, 1985

    CAS  Google Scholar 

  164. Quaife C, Hammer RE, Mottet NK, Palmiter RD: Glucocorticoid regulation of metallothionein during murine development. Dev Biol 118: 549, 1986

    Article  PubMed  CAS  Google Scholar 

  165. Quaife CJ, Pinkert CA, Ornitz DM, Palmiter RD, Brinster RL: Pancreatic neoplasia induced by ras expression in acinar cells of transgenic mice. Cell 48: 1023, 1987

    Article  PubMed  CAS  Google Scholar 

  166. Rassoulzadegan M, Leopold P, Vailly J, Cuzin F: Germ line transmission of autonomous genetic elements in transgenic mouse strains. Cell 46: 513, 1986

    Article  PubMed  CAS  Google Scholar 

  167. Readhead C, Popko B, Takahashi N, Shine HD, Saavedra RA, Sidman RL, Hood L: Expression of a myelin basic protein gene in transgenic shiverer mice: correction of the dysmyelinating phenotype. Cell 48: 703, 1987

    Article  PubMed  CAS  Google Scholar 

  168. Reik W, Collick A, Norris ML, Barton SC and Surani MA: Genomic imprinting determines methylation of parental alleles in transgenic mice. Nature 328: 248, 1987

    Article  PubMed  CAS  Google Scholar 

  169. Richmond IL, Wilson CB: Pituitary adenomas in childhood and adolescence. J Neurosurg 49: 163, 1978

    Article  PubMed  CAS  Google Scholar 

  170. Riggs AD, Singer-Sam J, Keith DH: Methylation of the PGK promoter region and an enhancer way-station model for X-chro-mosome inactivation. Prog Clin Biol Res. 198: 211, 1985

    PubMed  CAS  Google Scholar 

  171. Ritchie KA, Brinster RL, Storb U: Allelic exclusion and control of endogenous immunoglobulin gene rearrangement in kappa transgenic mice. Nature 312: 517, 1984

    Article  PubMed  CAS  Google Scholar 

  172. Rivier J, Spiess J, Thorner M, Vale W: Characterization of growth hormone-releasing factor from a human pancreatic islet tumor. Nature 300: 276, 1982

    Article  PubMed  CAS  Google Scholar 

  173. Robertson E, Bradley A, Kuehn M, Evans M: Germ-line transmission of genes introduced into cultured pluripotential cells by retroviral vector. Nature 323: 445, 1986

    Article  PubMed  CAS  Google Scholar 

  174. Robertson M: Gene therapy: desperate appliances. Nature (London) 320: 213, 1986

    Article  CAS  Google Scholar 

  175. Robl JM, First NL: Manipulation of gametes and embryos in the pig. J Reprod Fertil 33 (Suppl) 101, 1985

    CAS  Google Scholar 

  176. Ross SR, Solter D: Glucocorticoid regulation of mouse mammary tumor virus sequences in transgenic mice. Proc Natl Acad Sei USA 82: 5880, 1985

    Article  CAS  Google Scholar 

  177. Rusconi S, Kohler G: Transmission and expression of a specific pair of rearranged immunoglobulin n and k genes in a transgenic mouse line. Nature 314: 330, 1985

    Article  PubMed  CAS  Google Scholar 

  178. Rüther U, Garber C, Komitowski D, Müller R, Wagner EF: Deregulated c-fos expression interferes with normal bone development in transgenic mice. Nature 325: 412, 1987

    Article  PubMed  Google Scholar 

  179. Sapienza C, Peterson AC, Rossant J, and Balling R: Degree of methylation of transgenes is dependent on gamete of origin. Nature 328: 251, 1987

    Article  PubMed  CAS  Google Scholar 

  180. Rüther U, Tripodi M, Cortese R, Wagner EF: The human alpha-l-antitryp8in gene is efficiently expressed from two tissue-specific promoters in transgenic mice. Nucleic Acids Res 15: 751, 1987

    Article  Google Scholar 

  181. Sasaki H, Shigenobu T, Nakazato M, Yoshioka K, Matsuo H, Kato Y, Sakaki Y: Generation of transgenic mice producing a human transthyretin variant: a possible mouse model for familial amyoidotic polyneuropathy. Biochem Biophys Res Comm 139: 794, 1986

    Article  PubMed  CAS  Google Scholar 

  182. Schell JS: Transgenic plants as tools to study the molecular organization of plant genes. Science 237: 1176, 1987

    Article  Google Scholar 

  183. Schnieke A, Harbers K, Jaenisch R: Embryonic lethal mutation in mice induced by retrovirus insertion into the al(l) collagen gene. Nature 304: 315, 1983

    Article  PubMed  CAS  Google Scholar 

  184. Seeburg PH, Shine J, Martial JA, Baxter JD, Goodman HM: Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature 270: 486, 1977

    Article  PubMed  CAS  Google Scholar 

  185. Seiden RF, Skoskiewicz MJ, Howie KB, Russell PS, Goodman HM: Regulation of human insulin gene expression in transgenic mice. Nature 321: 525, 1986

    Article  Google Scholar 

  186. Seiden RF, Skoskiewicz MJ, Howie KB, Russell PS, Goodman HM: Implantation of genetically engineered fibroblasts into mice: implications for gene therapy. Science 236: 714, 1987

    Article  Google Scholar 

  187. Shani M: Tissue-specific expression of rat myosin light-chain 2 gene in transgenic mice. Nature 314: 283, 1985

    Article  PubMed  CAS  Google Scholar 

  188. Shani M: Tissue-specific and developmentally regulated expression of a chimeric actin-globin gene in transgenic mice. Mol Cell Biol 6: 2624, 1986

    PubMed  CAS  Google Scholar 

  189. Sifers RN, Carlson JA, Clift SM, DeMayo FJ, Bullock DW, Woo SLC: Tissue specific expression of the human alpha-1 antitrypsin gene in transgenic mice. Nucleic Acids Res 15: 1459, 1987

    Article  PubMed  CAS  Google Scholar 

  190. Simons JP, McClenaghan M, Clark AJ: Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice. Nature 328: 530, 1987

    Article  PubMed  CAS  Google Scholar 

  191. Sinn E, Müller W, Pattengale P, Tepler I, Wallace R, Leder P: Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo. Cell 49: 465, 1987

    Article  PubMed  CAS  Google Scholar 

  192. Small JA, Khoury G, Jay G, Howley PM, Scangos GA: Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc Natl Acad Sei USA 83: 8288, 1986

    Article  CAS  Google Scholar 

  193. Small JA, Scangos GA, Cork L, Jay G, Khoury G: The early region of human papovavirus JC induces dysmyelination in transgenic mice. Cell 4: 13, 1986

    Article  Google Scholar 

  194. Soriano P, Cone RD, Mulligan RC, Jaenisch R: Tissue-specific and ectopic expression of genes introduced into transgenic mice by retroviruses. Science 234: 1409, 1986

    Article  PubMed  CAS  Google Scholar 

  195. Soriano P, Gridley T, Jaenisch R: Retroviruses and insertional mutagenesis in mice: proviral integration at the Moy 34 locus leads to early embryonic death. Genes Dev. 1: 366, 1987

    Article  PubMed  CAS  Google Scholar 

  196. Soriano P, Jaenisch R: Retroviruses as probes for mammalian development: allocation of cells to the somatic and germ lineages. Cell 46: 19, 1986

    Article  PubMed  CAS  Google Scholar 

  197. Southern E: Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol 98: 503, 1975

    Article  PubMed  CAS  Google Scholar 

  198. Stewart TA, Wagner EF, Mintz B: Human beta globin sequences injected into mouse eggs, retained in adults and transmitted to progeny. Science 217: 1046, 1982

    Article  CAS  Google Scholar 

  199. Stewart TA, Pattengale PK, Leder P: Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/ myc fusion genes. Cell 38: 627, 1984

    Article  PubMed  CAS  Google Scholar 

  200. Storb U: Immunoglobulin transgenic mice. Ann Rev Immunol 5: 151, 1987

    Article  CAS  Google Scholar 

  201. Storb U, O’Brien RL, McMullen MD, Gollahon KA, Brinster RL: High expression of cloned immunoglobulin kappa gene in transgenic mice is restricted to B lymphocytes. Nature 310: 238, 1984

    Article  PubMed  CAS  Google Scholar 

  202. Storb U, Pinkert C, Arp B, Engler P, Gollahon K, Manz J, Brady W, Brinster RL: Transgenic mice with mu and kappa genes encoding antiphosphorylcholine antibodies. J Exp Med 164: 627, 1986

    Article  PubMed  CAS  Google Scholar 

  203. Stout JT, Chen HY, Brennard J, Caskey CT, Brinster RL: Expression of human HPRT in the central nervous system of transgenic mice. Nature 317: 250, 1985

    Article  PubMed  CAS  Google Scholar 

  204. Stuart GW, Searle PF, Palmiter RD: Identification of multiple metal regulatory elements in mouse metallothionein I promoter by assaying synthetic sequences. Nature 317: 828, 1985

    Article  PubMed  CAS  Google Scholar 

  205. Surani MAH, Barton SC, Norris ML: Development of reconstituted mouse eggs suggest imprinting of the genome during game-togenesis. Nature 308: 548, 1984

    Article  PubMed  CAS  Google Scholar 

  206. Swain JL, Stewart TA, Leder P: Parental legacy determines methylation and expression of an autosomal transgene: a molecular mechanism for parental imprinting. Cell 50: 719, 1987

    Article  PubMed  CAS  Google Scholar 

  207. Swanson LW, Simmons DM, Arriza J, Hammer R, Brinster R, Rosenfeld MG, Evans RM: Novel developmental specificity in the nervous system of transgenic animals expressing growth hormone fusion genes. Nature 317: 363, 1985

    Article  PubMed  CAS  Google Scholar 

  208. Swift GH, Hammer RE, MacDonald RJ, Brinster RL: Tissue-specific expression of the rat pancreatic elastase I gene in transgenic mice. Cell 38: 639, 1984

    Article  PubMed  CAS  Google Scholar 

  209. Tooze J (ed): The Molecular Biology of Tumor Viruses, New York, Cold Spring Harbor Laboratory, 1981

    Google Scholar 

  210. Townes TM, Lingrel JB, Chen HY, Brinster RL, Palmiter RD: Erythroid-specific expression of human beta-globin genes in transgenic mice. EMBO J 4: 1715, 1985

    PubMed  CAS  Google Scholar 

  211. Vaeck M, Reynaerts A, Hofte H, Jansens S, De Beuckeleer M, Dean C, Zabeau M, Van Montagu M, Leemans J: Transgenic plants protected from insect attack. Nature 328: 33, 1987

    Article  CAS  Google Scholar 

  212. van der Putten H, Botteri FM, Miller AD, Rosenfeld MG, Fan H, Evans RM, Verma IM: Efficient insertion of genes into the germ line via retroviral vectors. Proc Natl Acad Sci USA 82: 6148, 1985

    Article  PubMed  Google Scholar 

  213. van Dyke T, Finlay C, Levine AJ: A comparison of several lines of transgenic mice containing the SV40 early genes. Cold Spring Harbor Symp Quant Biol 50: 671, 1985

    PubMed  Google Scholar 

  214. Wagner EF, Stewart CL: Integration and expression of genes introduced into mouse embryos. In: Experimental Approaches to Mammalian Embryonic Development. Rossant J, and Petersen R (Eds), Cambridge University Press, Cambridge, 1986.

    Google Scholar 

  215. Wagner TE, Hoppe PC, Jollick JD, Scholl DR, Hodinka RL, Gault JB: Microinjection of a rabbit β-globulin gene in zygotes and its subsequent expression in adult mice and their offspring. Proc Natl Acad Sci USA 78: 6376, 1981

    Article  PubMed  CAS  Google Scholar 

  216. Wagner EF, Covarrubias L, Stewart TA, Mintz B: Prenatal lethalities in mice homozygous for human growth hormone gene sequences integrated in the germ line. Cell 35: 647, 1983

    Article  PubMed  CAS  Google Scholar 

  217. Wagner EF, Stewart TA, Mintz B: The human β-globulin gene and a functional viral thymidine gene in developing mice. Proc Natl Acad Sci USA 78: 5016, 1981

    Article  PubMed  CAS  Google Scholar 

  218. Weaver D, Costantini F, Imanishi-Kari T, Baltimore D: A transgenic immunoglobulin mu gene prevents rearrangement of endogenous genes. Cell 42: 117, 1985

    Article  PubMed  CAS  Google Scholar 

  219. Weaver D, Reis MH, Albanese C, Costantini F, Baltimore D, Imanishi-Kari T: Altered repertoire of endogenous immunoglobulin gene expression in transgenic mice containing a rearranged Mu heavy chain gene. Cell 45: 247, 1986

    Article  PubMed  CAS  Google Scholar 

  220. Welsh M, Hammer RE, Brinster RL, Steiner DF: Stimulation of growth hormone synthesis by glucose in islets of Langerhans isolated from transgenic mice. J Biol Chem 261: 1 2915, 1986

    Google Scholar 

  221. Westphal H. Overbeek PA, Khillan JS, Chepelinsky AB, Schmidt A, Mahon KA, Bernstein KE, Piatigrosky J, de Crombrugghe B: Promoter sequences of murine alpha A crystallin, murine alpha 2(1) collagen or of avian sarcoma virus genes linked to the bacterial chloramphenicol acetyltransferase gene direct tissue-specific patterns of chloramphenicol acetyltransferase expression in transgenic mice. Cold Spring Harbor Symp Quant Biol 50:411,1985

    PubMed  CAS  Google Scholar 

  222. Wilkie TM, Brinster RL, Palmiter RD: Germline and somatic mosaicism in transgenic mice. Dev Biol 118: 9, 1986

    Article  PubMed  CAS  Google Scholar 

  223. Williams DA, Lemischka IR, Nathan DG, Mulligan RC: Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature (London) 310: 476, 1984

    Article  CAS  Google Scholar 

  224. Williams DA, Orkin SH: Somatic gene therapy: current status and future prospects. J Clin Invest 77: 1053, 1986

    Article  PubMed  CAS  Google Scholar 

  225. Williams DA, Orkin SH, Mulligan RC: Retrovirus-mediated transfer of human adenosine deaminase gene sequences into cells in culture and into murine hematopoietic cell in vivo. Proc Natl Acad Sci USA 83: 2566, 1986

    Article  PubMed  CAS  Google Scholar 

  226. Wolf SF, Jolly DJ, Lunnen KD, Friedmann T, Migeon BR: Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci USA 81: 2806, 1984

    Article  PubMed  CAS  Google Scholar 

  227. Woychik RP, Stewart TA, Davis LG, D’Eustachio P, Leder P: An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature 318: 36, 1985.

    Article  PubMed  CAS  Google Scholar 

  228. Yagaloff KA, Lozano G, van Dyke T, Levine AJ, Hartig PR: Serotonin 5-HTlc receptors are expressed at high density on choroid plexus tumors from transgenic mice. Brain Res 385:389,1986

    Article  PubMed  CAS  Google Scholar 

  229. Yamamoto KR: Steroid receptor regulated transcription of specific genes and gene networks. Ann Rev Genet 19: 209, 1985

    Article  PubMed  CAS  Google Scholar 

  230. Yamamura K, Kitutani H, Folsom V, Clayton LK, Kimoto M, Akira S, Kashiwamura S, Tonegawa S, Kishimoto T: Functional expression of a microinjected Ed alpha gene in C57BL/6 transgenic mice. Nature 216: 67, 1985

    Article  Google Scholar 

  231. Yamamura K, Kudo A, Ebihara T, Kamino K, Araki K, Kumahara Y, Watanabe T: Cell-type-specific and regulated expression of a human gamma 1 heavy-chain immunoglobulin gene in transgenic mice. Proc Natl Acad Sci USA 83: 2152, 1986

    Article  PubMed  CAS  Google Scholar 

  232. Yen PH, Patel P, Chanault AC, Mohandas T, Shapiro LJ: Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes. Proc Natl Acad Sci USA 81: 1759, 1984

    Article  PubMed  CAS  Google Scholar 

  233. Yu, S-F, Rüden IV, Kantoff PW, Garber C, Seibers M, Ruther U, Anderson WF, Wagner EF, Gilboa E: Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. Proc Natl Acad Sci USA 83: 3194, 1986

    Article  PubMed  CAS  Google Scholar 

  234. Zu Rhein GM, Chou S: Particles resembling papova viruses in human demyelinating disease. Science 148: 1477, 1965

    Article  Google Scholar 

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Authors and Affiliations

  1. Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Melbourne, Australia

    R. Andrew Cuthbertson (Australian Post-Doctoral Fellow of the Australian National Health and Medical Research Council) & Gordon K. Klintworth M.D., Ph.D.

  2. Departments of Pathology and Ophthalmology, Duke University Medical Center, Durham, North Carolina, USA

    R. Andrew Cuthbertson (Australian Post-Doctoral Fellow of the Australian National Health and Medical Research Council) & Gordon K. Klintworth M.D., Ph.D.

  3. Department of Pathology, Duke University Medical Center, Durham, NC, 27710, USA

    Gordon K. Klintworth M.D., Ph.D.

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  1. Department of Pathology and Cell Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

    Emanuel Rubin MD (Gonzalo Aponte Professor and Chairman) & Ivan Damjanov MD (Professor) (Gonzalo Aponte Professor and Chairman) &  (Professor)

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Cuthbertson, R.A., Klintworth, G.K. (1989). Transgenic Mice—A Gold Mine for Furthering Knowledge in Pathobiology. In: Rubin, E., Damjanov, I. (eds) Pathology Reviews · 1989. Humana Press. https://doi.org/10.1007/978-1-4612-4502-5_14

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