Kinetics of Anion Transport

  • Philip A. Knauf
Part of the Contemporary Biomedicine book series (CB, volume 10)

Abstract

This chapter will deal primarily with the question of what we can learn about the red-cell anion transport system from kinetic studies, that is, measurements of ion fluxes under different conditions and in the presence of various inhibitors. It is important to recognize, however, that one of the chief advantages of the red-cell anion transport system has been the availability of structural data on the transport protein as well as kinetic data. Largely for reasons of brevity, this chapter will focus on only a few subjects that, in my opinion, will be important in linking the kinetic information with structural studies (see Chapter 8) to develop a molecular model for the transport process. For a broader overview of the kinetics of transport, the reader is referred to several comprehensive reviews (Macara and Cantley, 1983; Knauf, 1979, 1986; Passow, 1986; Fröhlich and Gunn, 1986).

Keywords

Permeability Entropy Enthalpy Superoxide Lysine 

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  • Philip A. Knauf

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