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Catalytic Mechanisms of the Ca-Pump ATPase

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The Red Cell Membrane

Part of the book series: Contemporary Biomedicine ((CB,volume 10))

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Abstract

Under physiological conditions, the activity of calcium, that is, the concentration of free ionized calcium (Ca2+) in the cytosol of human red cells, is less than 10-7 M, which is about 104 times lower than that present in the blood plasma (see Rega and Garrahan, 1986). Although the passive permeability of the red-cell membrane to Ca2+ is very low, there is a small but permanent leak of Ca2+ into the cell. Hence, active transport of Ca2+ to the extracellular medium is required to maintain the low concentration of Ca2+ in the cytosol.

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Authors
  1. Alcides F. Rega
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  2. Patricio J. Garrahan
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Evansville, Indiana, USA

    B. U. Raess

  2. Department of Biochemistry, Indiana University School of Medicine, Evansville, Indiana, USA

    Godfrey Tunnicliff

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© 1989 The Humana Press Inc.

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Rega, A.F., Garrahan, P.J. (1989). Catalytic Mechanisms of the Ca-Pump ATPase. In: Raess, B.U., Tunnicliff, G. (eds) The Red Cell Membrane. Contemporary Biomedicine, vol 10. Humana Press. https://doi.org/10.1007/978-1-4612-4500-1_6

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  • DOI: https://doi.org/10.1007/978-1-4612-4500-1_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8848-0

  • Online ISBN: 978-1-4612-4500-1

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