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The Molecular Structure of the Na,K-ATPase

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The Red Cell Membrane

Part of the book series: Contemporary Biomedicine ((CB,volume 10))

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Abstract

The sodium- and potassium-activated ATPase, or the Na,K-pump (Na,K-ATPase), maintains a low intracellular concentration of sodium and a high intracellular concentration of potassium in all animal cells. These concentration gradients are necessary for a variety of physiological functions, including regulation of cell volume, maintenance of osmotic pressure, Na+-coupled transport of certain organic and inorganic molecules, and electrical excitability of nerve and muscle (for review, see Stekhoven and Bonting, 1981). The Na,K-ATPase effects the coupled transports of three sodium ions out of the cell and two potassium ions into the cell. The energy required for this active transport is derived from the hydrolysis of ATP (for review, see Wallick et al., 1979; Kaplan, 1985).

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Authors
  1. Lee Ann Baxter-Lowe
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  2. Lowell E. Hokin
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Evansville, Indiana, USA

    B. U. Raess

  2. Department of Biochemistry, Indiana University School of Medicine, Evansville, Indiana, USA

    Godfrey Tunnicliff

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Baxter-Lowe, L.A., Hokin, L.E. (1989). The Molecular Structure of the Na,K-ATPase. In: Raess, B.U., Tunnicliff, G. (eds) The Red Cell Membrane. Contemporary Biomedicine, vol 10. Humana Press. https://doi.org/10.1007/978-1-4612-4500-1_3

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  • DOI: https://doi.org/10.1007/978-1-4612-4500-1_3

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