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Calcium Fluxes in Pathologically Altered Red Cells

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Part of the book series: Contemporary Biomedicine ((CB,volume 10))

Abstract

Calcium flux is defined as the amount of calcium ions crossing unit area of a membrane in unit time. In red blood cells with no intracellular organelles surrounded by membrane structures, calcium flux refers solely to transport through the plasma membrane, and this transport may be directed inwards (influx) or outwards (efflux). The calcium flux may be passive (i.e., electrodiffusion) or active (i.e., mediated by the calcium pump).

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References

  • Akoğlu, T., Ozdogu, H., Erdoğan, R., and Özer, F. L. (1984) Erythrocyte membrane ATPase activity of G6PD-deficient individuals and the effect of primaquine metabolite(s) on membrane ATPase enzymes. J. Tropic. Med. Hyg. 87 219–224.

    Google Scholar 

  • Alexander, D. R., Deeb, ML, Bitar, F., and Antun, F. (1986) Sodiumpotassium, magnesium, and calcium ATPase activities in erythrocyte membranes from manic-depressive patients responding to lithium. Biol. Psychiatry 21 997–1007.

    Article  PubMed  CAS  Google Scholar 

  • Al-Jobore, Α., Minocherhomjee, A. M., Villalobo, Α., and Roufogalis, B. D. (1984) Active calcium transport in normal and abnormal human erythrocytes, in Erythrocyte Membranes 3: Recent Clinical and Experimental Advances (Kruckeberg, W. C., Eaton, J. W., Aster, J., and Brewer, G. J., eds.), Alan R. Liss, New York, pp. 243–292.

    Google Scholar 

  • Allan, D., Thomas, P., and Limbrick, A. R. (1980) The isolation and characterization of 60 nm vesicles (‘nanovesicles’) produced during ionophore A23187-induced budding of human erythrocytes. Biochem. J. 188 881–887.

    PubMed  CAS  Google Scholar 

  • Allen, B. G., Bridges, M., Roufogalis, B. D., and Katz, S. (1986) Investigation of (Ca2+ + Mg2+)-ATPase phospho-protein formation in erythrocyte membranes of patients with cystic fibrosis. Cell Calcium 7 161–168.

    Article  PubMed  CAS  Google Scholar 

  • Ansah, T. and Katz, S. (1980) Evidence for a Ca2+-transport deficiency in patients with cystic fibrosis. Cell Calcium 1 195–203.

    Article  CAS  Google Scholar 

  • Asai, T., Fujioka, S., and Yoshida, S. (1985) Erythrocyte membrane associated enzymes of hemolytic anemias: ATPases, AMP deaminase and GAPD. Acta Haematol. Jpn. 48 12–21.

    CAS  Google Scholar 

  • Becker, P. S. and Lux, S. E. (1985) Hereditary spherocytosis and related disorders. Clin. Haematol. 14 15–43.

    PubMed  CAS  Google Scholar 

  • Bookchin, R. M., Ortiz, O. E., and Lew, V. L. (1984) Silent intracellular calcium in sickle cell anemia red cells, in The Red Cell: Sixth Ann Arbor Conference (Brewer, G. J., ed.), Alan R. Liss, New York, pp. 17–28.

    Google Scholar 

  • Bookchin, R. M., Raventos, C, Nagel, R. L., and Lew, V. L. (1981) Abnormal K and Ca transport and Ca accumulation in red cells infected in vitro with Plasmodium falciparum. Clin. Res. 29 516A.

    Google Scholar 

  • Bookchin, R. M., Ortiz, O. E., Hockaday, Α., Sepulveda, M. I., and Lew, V. L. (1986) The state of calcium in sickle cell anaemia red cells, in Intracellular Calcium Regulation (Bader, H., Gietzen, K., Rosenthal, J., Rüdel, R., and Wolf, H. U., eds.), Manchester University Press, Manchester, pp. 327–334.

    Google Scholar 

  • Bridges, M. A. and Katz, S. (1986) Isolation and characterization of erythrocyte membrane Ca2+-ATPase in cystic fibrosis. Pediatr. Res. 20 356–360.

    Article  PubMed  CAS  Google Scholar 

  • Choi, S. J., Derman, R. M., and Lee, K. S. (1981) Bipolar affective disorder, lithium carbonate and Ca++ ATPase. J. Affect. Disorders 3 77–79.

    Article  PubMed  CAS  Google Scholar 

  • Clough, D. L. and Hubbard, V. S. (1984) Red cell membrane Ca-ATPase in cystic fibrosis: increased activation by Na. Clin. Chim. Acta 138 259–265.

    Article  PubMed  CAS  Google Scholar 

  • Dagher, G. and Amar, M. (1986) Maximal velocity of the Ca pump in RBC of SHR and essential hypertensive patients, in Proceedings of European Red Cell Club Conference, Visegrád, Hungary.

    Google Scholar 

  • Dearborn, D. G., Wityk, R. J., Johnson, L. R., Poncz, L., and Stern, R. C. (1984) Calcium-ATPase activity in cystic fibrosis erythrocyte membranes: decreased activity in patients with pancreatic insufficiency. Pediatr. Res. 18 890–895.

    Article  PubMed  CAS  Google Scholar 

  • De Flora, A., Benatti, U., Guida, L., Forteleoni, G., and Meloni, T. (1985) Favism: disordered erythrocyte calcium homeostasis. Blood 66 294–297.

    PubMed  Google Scholar 

  • Dixon, E. and Winslow, R. M. (1981) The interaction between (Ca2+ + Mg2+)-ATPase and the soluble activator (calmodulin) in erythrocytes containing haemoglobin S. Brit. J. Haematol. 47 391–397.

    Article  CAS  Google Scholar 

  • Dube, M. P., Davis, F. B., Davis, P. J., Schoenl, M., and Blas, S. D. (1986) Effects of hyperthyroidism and hypothyroidism on human red blood cell Ca2+ -ATPase activity. J. Clin. Endocrinol. Metab. 62 253–257.

    Article  PubMed  CAS  Google Scholar 

  • Dubovsky, S. L. and Franks, R. D. (1983) Intracellular calcium ions in affective disorders: a review and an hypothesis. Biol. Psychiatry 18, 781–797.

    PubMed  CAS  Google Scholar 

  • Eaton, J. W., Skelton, T. D., Swofford, H. S., Kolpin, C. E., and Jacob, H. S. (1973) Elevated erythrocyte calcium in sickle cell disease. Nature 246 105–106.

    Article  PubMed  CAS  Google Scholar 

  • Feig, S. A. and Bassilian, S. (1975) Increased erythrocyte Ca2+ content in hereditary spherocytosis. Pediat. Res. 9 928–931.

    PubMed  CAS  Google Scholar 

  • Feig, S. A. and Guidotti, G. (1974) Relative deficiency of Ca2+ -dependent adenosine triphosphatase activity of red cell membranes in hereditary spherocytosis. Biochem. Biophys. Res. Commun. 58 487–494.

    Article  PubMed  CAS  Google Scholar 

  • Foder, B., Scharff, O., and Tønnesen, P. (1980) Activator-associated Ca2+ -ATPase in erythrocyte membranes from cystic fibrosis patients. Clin. Chim. Acta. 104 187–193.

    Article  PubMed  CAS  Google Scholar 

  • Gietzen, K., Dick, B., Hauser, U., and Bader, H. (1984) Calmodulin and Ca++-transport ATPase in erythrocytes from cystic fibrosis patients. Cell Calcium 5 307.

    Article  Google Scholar 

  • Ginsburg, H., Handeli, S., Gorodetsky, R., Friedman, S., and Krugliak, M. (1986) What is the mechanism of sickle trait cell resistance to malaria?, in Proceedings of European Red Cell Club Conference, Visegrád, Hungary.

    Google Scholar 

  • Gopinath, R. M. and Vincenzi, F. F. (1979) (Ca2+ + Mg2+)-ATPase activity of sickle cell membranes: Decreased activation by red blood cell cytoplasmic activator. Amer. J. Hematol. 7 303–312.

    Article  CAS  Google Scholar 

  • Gunn, R. B., Silvers, D. N., and Rosse, W. F. (1972) Potassium permeability in β-thalassemia minor red blood cells. J. Clin. Invest. 51 1043–1049.

    Article  PubMed  CAS  Google Scholar 

  • Hunsinger, R. N. and Cheung, H. C. (1986) Probe of the (Ca2+ + Mg2+)-ATPase in erythrocyte membranes of cystic fibrosis patients. Clin. Chim. Acta 156 165–178.

    Article  PubMed  CAS  Google Scholar 

  • Johnsson, R., Santaholma, S., and Saris, N. (1978) Calcium transport and adenosine triphosphatase activities of erythrocyte membranes in congenital spherocytosis. Scand. J. Clin. Lab. Invest. 38 121–125.

    PubMed  CAS  Google Scholar 

  • Katz, S. (1978) Calcium and sodium transport processes in patients with cystic fibrosis. I. A specific decrease in Mg2+-dependent, Ca2+-adenosine triphosphatase activity in erythrocyte membranes from cystic fibrosis patients. Pediatr. Res. 12 1033–1038.

    Article  PubMed  CAS  Google Scholar 

  • Katz, S., Schoni, M. H., and Bridges, M. A. (1984) The calcium hypothesis of cystic fibrosis. Cell Calcium 5 421–440.

    Article  PubMed  CAS  Google Scholar 

  • Kirkpatrick, F. H., Woods, G. M., and LaCelle, P. L. (1975) Absence of one component of spectrin adenosine triphosphatase in hereditary spherocytosis. Blood 46 945–954.

    PubMed  CAS  Google Scholar 

  • Krungkrai, J. and Yuthavong, Y. (1983) Enhanced Ca2+ uptake by mouse erythrocytes in malarial (Plasmodium berghei) infection. Mol. Biochem. Parasitol. 7 227–235.

    Article  PubMed  CAS  Google Scholar 

  • Leida, M. N., Mahoney, J. R., and Eaton, J. W. (1981) Intraerythrocytic plasmodial calcium metabolism. Biochem. Biophys. Res. Commun. 103 402–406.

    Article  PubMed  CAS  Google Scholar 

  • Lew, V. L., Hockaday, Α., Sepulveda, M., Somlyo, A. P., Somlyo, A. V., Ortiz, O. E., and Bookchin, R. M. (1985) Compartmentalization of sicklecell calcium in endocytic inside-out vesicles. Nature 315 586–589.

    Article  PubMed  CAS  Google Scholar 

  • Lin, S., Hong, C, Chiang, B. N., and Wei, Y. (1985) Activities of transport adenosine triphosphatases in erythrocyte membranes of healthy and hypertensive subjects. Clin. Exp. Hypertens. A7 1151–1163.

    Article  CAS  Google Scholar 

  • Lorand, L. and Michalska, M. (1985) Altered response of stored red cells to Ca2+ stress. Blood 65 1025–1027.

    PubMed  CAS  Google Scholar 

  • Lubin, B., Chiu, D., Bastacky, J., Roelofsen, B., and van Deenen, L. L. M. (1981) Abnormalities in membrane phospholipid organization in sickled erythrocytes. J. Clin. Invest. 67 1643–1649.

    Article  PubMed  CAS  Google Scholar 

  • Luthra, M. G. and Sears, D. A. (1982) Increased Ca2+, Mg2 +, and Na+ + K+ ATPase activities in erythrocytes of sickle cell anemia. Blood 60 1332–1336.

    PubMed  CAS  Google Scholar 

  • MacDonald, E., Rubinow, D., and Linnoila, M. (1984) Sensitivity of RBC membrane Ca2+-adenosine triphosphatase to calmodulin stimulation. Arch. Gen. Psychiatry 41 487–493.

    PubMed  CAS  Google Scholar 

  • Mayman, D. and Zipursky, A. (1974) Hereditary spherocytosis: the metabolism of erythrocytes in the peripheral blood and the splenic pulp. Brit. J. Haematol. 27 201–217.

    Article  CAS  Google Scholar 

  • Meltzer, H. L. and Kassir, S. (1983) Abnormal calmodulin-activated Ca ATPase in manic-depressive subjects. J. Psychiat. Res. 17 29–35.

    Article  CAS  Google Scholar 

  • Mikkelsen, R. B., Geller, Ε., Doren, Ε. V., and Asher, C. R. (1984) Ca2+ metabolism of Ρlasmodia-infected erythrocytes. Prog. Clin. Biol. Res. 155 25–34.

    PubMed  CAS  Google Scholar 

  • Mole, P. A. and Paterson, C. R. (1985) Calcium-ATPase activity in erythrocyte ghosts from patients with familial benign hypercalcaemia. Scand. J. Clin. Lab. Invest. 45 349–353.

    Article  PubMed  CAS  Google Scholar 

  • Muallem, S., Miner, C., and Seymour, C. A. (1985) The nature of the Ca2+ pump defect in the red blood cells of patients with cystic fibrosis. Biochim. Biophys. Acta 819 143–147.

    Article  PubMed  CAS  Google Scholar 

  • Murphy, E., Berkowitz, L. R., Orringer, E., Levy, L., Gabel, S. Α., and London, R. E. (1987) Cytosolic free calcium levels in sickle red blood cells. Blood 69 1469–1474.

    PubMed  CAS  Google Scholar 

  • Niggli, V., Adunyah, E. S., Cameron, B. F., Bababunmi, Ε. Α., and Carafoli, E. (1982) The Ca2+-pump of sickle cell plasma membranes. Purification and reconstitution of the ATPase enzyme. Cell Calcium 3 131–151.

    Article  PubMed  CAS  Google Scholar 

  • Okada, T., Kuwahara, T., and Nakamura, K. (1985) Ca++ and morphological changes in erythrocytes of stroke-prone SHR. Jpn. Heart J. 26 685.

    Article  Google Scholar 

  • Olorunsogo, O. O., Okudolo, B. E., Lawa, S. Ο. Α., and Falase, A. O. (1985) Erythrocyte membrane Ca2+ -pumping ATPase of hypertensive humans: Reduced stimulation by calmodulin. Biosci. Rep. 5 525–531.

    Article  PubMed  CAS  Google Scholar 

  • Ortiz, O. E., Lew, V. L., and Bookchin, R. M. (1986) Calcium accumulated by sickle cell anemia red cells does not affect their potassium (86Rb+) flux components. Blood 67, 710–715.

    PubMed  CAS  Google Scholar 

  • Palek, J. (1977) Red cell calcium content and transmembrane calcium movements in sickle cell anemia. J. Lab. Clin. Med. 89 1365–1374.

    PubMed  CAS  Google Scholar 

  • Parker, J. and Berkowitz, L. R. (1983) Physiologically instructive genetic variants involving the human red cell membrane. Physiol. Rev. 63 261–313.

    PubMed  CAS  Google Scholar 

  • Pliszka, S. R. and Rogeness, G. A. (1984) Calcium and magnesium in children with schizophrenia and major depression. Biol. Psychiatry 19 871–876.

    PubMed  CAS  Google Scholar 

  • Postnov, Y. V. and Orlov, S. N. (1985) Ion transport across plasma membrane in primary hypertension. Physiol. Rev. 65 904–945.

    PubMed  CAS  Google Scholar 

  • Postnov, Y. V., Orlov, S. N., Reznikova, M. B., Rjazhsky, G. G., and Pokudin, N. I. (1984) Calmodulin distribution and Ca2+ transport in the erythrocytes of patients with essential hypertension. Clin. Sci. 66 459–463.

    PubMed  CAS  Google Scholar 

  • Rachmilewitz, Ε. Α., Shinar, E., Shalev, O., Galili, U., and Schrier, S. L. (1985) Erythrocyte membrane alterations in β-thalassaemia. Clin. Haematol. 14 163–182.

    PubMed  CAS  Google Scholar 

  • Ramanadham, M. and Kaplay, S. S. (1982) Erythrocyte osmotic fragility in protein-energy malnutrition: cholesterol, phospholipid, and Ca2+, Mg2+ adenosine triphosphatase. Biochem. Med. 27 226–231.

    Article  PubMed  CAS  Google Scholar 

  • Rhoda, M. D., Beuzard, Y., Apovo, M., Galacteros, F., and Giraud, F. (1988) Ca2+ permeability in deoxygenated sickle erythrocytes. Proceedings of Structure et Fonctions de la Membrane du Globule Rouge (Cadarache, France).

    Google Scholar 

  • Rhoda, M. D., Galacteros, F., Beuzard, Y., and Giraud, F. (1987) Ca2+ permeability and cytosolic Ca2+ concentration are not impaired in β-thalassemic and hemoglobin C erythrocytes. Blood 70 804–808.

    PubMed  CAS  Google Scholar 

  • Rhoda, M. D., Giraud, F., Craescu, C. T., and Beuzard, Y., (1985) Compartmentalization of Ca2+ in sickle cells. Cell Calcium 6 397–411.

    Article  PubMed  CAS  Google Scholar 

  • Rubin, E., Schlegel, R. Α., and Williamson, P. (1986) Endocytosis in sickle erythrocytes: a mechanism for elevated intracellular Ca2+ levels. J. Cell Physiol. 126 53–59.

    Article  PubMed  CAS  Google Scholar 

  • Rüdel, R. and Lehmann-Horn, F. (1985) Membrane changes in cells from myotonia patients. Physiol. Rev. 65 310–356.

    PubMed  Google Scholar 

  • Scharff, O. and Foder, B. (1975) Decreased (Ca2+ + Mg2+)-stimulated ATPase activity in erythrocyte membranes from polycythemia vera patients. Scand. J. Clin. Lab. Invest. 35 583–589.

    PubMed  CAS  Google Scholar 

  • Scharff, O., Foder, B., and Skibsted, U. (1983) Hysteretic activation of the Ca2+ pump revealed by calcium transients in human red cells. Biochim. Biophys. Acta 730 295–305.

    Article  PubMed  CAS  Google Scholar 

  • Shalev, O., Lavi, V., Hebbel, R. P., and Eaton, J. W. (1985) Erythrocyte (Ca2+ + Mg2+)-ATPase activity: increased sensitivity to oxidative stress in glucose-6-phosphate dehydrogenase deficiency. Amer. J. Hematol. 19 131–136.

    Article  CAS  Google Scholar 

  • Shalev, O., Mogilner, S., Shinar, E., Rachmilewitz, Ε. Α., and Schrier, S. L. (1984) Impaired erythrocyte calcium homeostasis in β-thalassemia. Blood 64 564–566.

    PubMed  CAS  Google Scholar 

  • Shimoda, M. and Yawata, Y. (1985a) A marked increase of calcium uptake in the ATP-depleted red cells of patients with iron deficiency. Amer. J. Hematol. 19 55–61.

    Article  CAS  Google Scholar 

  • Shimoda, M. and Yawata, Y. (1985b) An increased calcium accumulation in ATP-depleted red cells of the patients with paroxysmal nocturnal hemoglobinuria. Amer. J. Hematol. 20 325–335.

    Article  CAS  Google Scholar 

  • Shimoda, M., Miyashima, K., and Yawata, Y. (1984) Increased calcium uptake in the red cells of unsplenectomized patients with hereditary spherocytosis: significant contribution of reticulocytosis. Clin. Chim. Acta 142 183–192.

    Article  PubMed  CAS  Google Scholar 

  • Siegal, V. and Settlemire, C. T. (1984) Calcium efflux and cell morphology changes in red blood cells from normal subjects and patients with cystic fibrosis, in Cystic Fibrosis: Horizons (Lawson, D., ed.), John Wiley, Chichester, p. 403.

    Google Scholar 

  • Steinberg, M. H., Eaton, J. W., Berger, Ε., Coleman, Μ. Β., and Oelshlegel, F. J. (1978) Erythrocyte calcium abnormalities and the clinical severity of sickling disorders. Brit. J. Haematol. 40 533–539.

    Article  CAS  Google Scholar 

  • Strzyzewski, W., Rybakowski, J., Potok, E., and Zelechowska-Ruda, E. (1984) Erythrocyte cation transport in endogenous depression: clinical and psychophysiological correlates. Acta Psychiatr. Scand. 70 248–253.

    Article  PubMed  CAS  Google Scholar 

  • Tanabe, K., Mikkelsen, R. B., and Wallach, D. F. H. (1982) Calcium transport of Plasmodium chabaudi-infected erythrocytes. J. Cell Biol. 93 680–684.

    Article  PubMed  CAS  Google Scholar 

  • Tsuchiya, Y. and Sugai, H. (1982) The effect of Mycoplasma pneumoniae infection on human erythrocytes: changes in osmotic fragility, lipid composition, sialic acid content, Ca2+ -ATPase activities, and ATP concentration. Biochem. Med. 28 256–265.

    Article  PubMed  CAS  Google Scholar 

  • Turrini, F., Mannuzzu, L., Naitana, Α., and Arese, P. (1988) Effect of divicine on passive calcium permeability in G6PD-deficient cells. Proceedings of Structure et Fonctions de la Membrane du Globule Rouge (Cadarache, France).

    Google Scholar 

  • Turrini, F., Naitana, Α., Mannuzzu, L., Pescarmona, G., and Arese, P. (1985) Increased red cell calcium, decreased calcium adenosine triphosphatase, and altered membrane proteins during fava bean hemolysis in glucose-6-phosphate dehydrogenase-deficient (Mediterranean variant) individuals. Blood 66 302–305.

    PubMed  CAS  Google Scholar 

  • Vettore, L., Falezza, G. C, Cetto, G. L., and DeMatteis, M. C. (1974) Cation content and membrane deformability of heterozygous β-thalassaemic red blood cells. Brit. J. Haematol. 27 429–437.

    Article  CAS  Google Scholar 

  • Vincenzi, F. F., McCarron, D. Α., and Morris, C. D. (1985) Another marker of hypertension in red blood cells? Fed. Proc. 44 1041.

    Google Scholar 

  • Vogel, F. and Motulsky, A. G. (1986) Human Genetics. Problems and Approaches (Springer Verlag, Berlin).

    Google Scholar 

  • Waller, R. L., Johnson, L. R., Brattin, W. J., and Dearborn, D. G. (1985) Erythrocyte cytosolic free Ca2+ and plasma membrane Ca2+-ATPase activity in cystic fibrosis. Cell Calcium 6 245–264.

    Article  PubMed  CAS  Google Scholar 

  • Wehling, M., Vetter, W., Neyses, L., Groth, H., Boerlin, H. J., Locher, R., Siegenthaler, W., and Kuhlmann, U. (1983). Altered calcium and sodium metabolism in red blood cells of hypertensive man: assessment by ion-selective electrodes. J. Hypertens. 1 171–176.

    Article  PubMed  CAS  Google Scholar 

  • Wiley, J. S. and Gill, F. M. (1976) Red cell calcium leak in congenital hemolytic anemia with extreme microcytosis. Blood 47 197–210.

    PubMed  CAS  Google Scholar 

  • Zail, S.S. and van den Hoek, A. K. (1976) Studies on calcium transport and calcium-dependent adenosine triphosphatase activity of erythrocyte membranes in hereditary spherocytosis. Brit. J. Haematol. 34 605–611.

    Article  CAS  Google Scholar 

  • Zidek, W., Vetter, H., Dorst, Κ., Zumkley, Η., and Losse, H. (1982) Intracellular Na+ and Ca2+ activities in essential hypertension. Clin. Sci. 63 41s–43s.

    Google Scholar 

  • Zidek, W., Karoff, C, Baumgart, P., Losse, H., Fehske, K. J., Häcker, W., and Vetter, Η. (1985) Intracellular sodium and calcium during antihypertensive treatment. Klin. Wochenschr. 63, (Suppl. III) 147–149.

    PubMed  Google Scholar 

  • Zipursky, Α., Brown, E. J., and Chachula, D. M. (1986) Erythrocyte vacuoles in hereditary spherocytosis. Brit. J. Haematol. 62 775–776.

    Article  CAS  Google Scholar 

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Scharff, O., Foder, B. (1989). Calcium Fluxes in Pathologically Altered Red Cells. In: Raess, B.U., Tunnicliff, G. (eds) The Red Cell Membrane. Contemporary Biomedicine, vol 10. Humana Press. https://doi.org/10.1007/978-1-4612-4500-1_18

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  • DOI: https://doi.org/10.1007/978-1-4612-4500-1_18

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