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Pharmacological Modification of the Red Cell Ca2+-Pump

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Book cover The Red Cell Membrane

Part of the book series: Contemporary Biomedicine ((CB,volume 10))

Abstract

When studying drugs that affect Ca2+ homeostasis, either directly or indirectly, it is important to consider all factors in the equation determining a precisely controlled level of intracellular Ca2+ activity. One such factor in this equation is the highly regulated, intricately controlled plasma membrane (Ca2++Mg2+)-ATPase and Ca2+ extrusion mechanism henceforth referred to as the Ca2+-pump. Because of its prominent position in the plasma membrane of all mammalian and perhaps all eukaryotic cells, it is legitimate to assume that this transport mechanism is a potential target for all kinds of drugs and certainly for those that are known to alter the calcium message on the inside of the cell.

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Authors
  1. B. U. Raess
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Editors and Affiliations

  1. Department of Pharmacology and Toxicology, Indiana University School of Medicine, Evansville, Indiana, USA

    B. U. Raess

  2. Department of Biochemistry, Indiana University School of Medicine, Evansville, Indiana, USA

    Godfrey Tunnicliff

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© 1989 The Humana Press Inc.

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Raess, B.U. (1989). Pharmacological Modification of the Red Cell Ca2+-Pump. In: Raess, B.U., Tunnicliff, G. (eds) The Red Cell Membrane. Contemporary Biomedicine, vol 10. Humana Press. https://doi.org/10.1007/978-1-4612-4500-1_14

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  • DOI: https://doi.org/10.1007/978-1-4612-4500-1_14

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8848-0

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