The Hemopoietic Extracellular Matrix

  • Kenneth S. Zuckerman
  • Charles W. Prince
  • Steffen Gay
Part of the Contemporary Biomedicine book series (CB, volume 9)


Despite the fact that hemopoietic progenitor cells circulate freely in the blood and are exposed to the microenvironments of virtually every organ of the body, hematopoietic cell proliferation and differentiation normally is confined to a limited number of organs that differ during various stages of ontogeny and in different species.1–5 In humans, the yolk sac is the site of hemopoiesis in the early embryonic stages. The liver becomes the major hemopoietic organ during the end of the first trimester and through most of the second trimester, and the spleen has a minor hemopoietic role in the middle portion of fetal development. In the last trimester, the liver and spleen lose their capacity to support hemopoiesis.


Hyaluronic Acid Extracellular Matrix Component Demineralized Bone Matrix Hemopoietic Cell Bone Marrow Cell Culture 
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© The Humana Press Inc. 1989

Authors and Affiliations

  • Kenneth S. Zuckerman
  • Charles W. Prince
  • Steffen Gay

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