Selection of Microbial Sources of Bioactive Compounds

  • Yuzuru Iwai
  • Yōko Takahashi
Part of the Brock/Springer Series in Contemporary Bioscience book series (BROCK/SPRINGER)


Soon after penicillin was rediscovered as an antibiotic and named the “yellow magic medicine,” a new field of applied microbiology, i.e., that is, antibiotic screening, was introduced, especially by S.A. Waksman, who discovered streptomycin. A large number of bioactive metabolites have been isolated from various microbial sources, such as actinomycetes, bacteria, fungi, mushrooms, etc., but actinomycetes have proved to be the most important as antibiotic producers. The new antibiotics found in 1980 were derived from actinomycetes (80.4%), bacteria (11.4%), and fungi-mushrooms (8.3%); about 75% of those discovered during 1971–1980 were also from this group of microorganisms (Higashide and Yamamoto, 1982). An efficient way of finding new bioactive metabolites is by the discovery of new microorganisms, and many approaches have been used.


Bioactive Compound Aerial Mycelium Bioactive Metabolite Microbial Source Selective Isolation 
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© Spring-Verlag New York, Inc. 1992

Authors and Affiliations

  • Yuzuru Iwai
  • Yōko Takahashi

There are no affiliations available

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