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Glucocorticoid Actions on Normal and Neoplastic Lymphocytes: Activation of Apoptosis

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Hormones and Cancer

Part of the book series: Hormones in Health and Disease ((HHD))

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Abstract

The glucocorticoid steroid hormones are used as part of treatment plans for some forms of cancer because of their lytic and growth suppressive effects (see Chapter 17, this volume). It was believed for a long time that the lytic effect of glucocorticoids occurred only in thymocytes; however, it has now been shown that B cells are also sensitive to glucocorticoid treatment (Distelhorst, 1988; McConkey et al., 1991). Glucocorticoids are prescribed in the cases of chronic myeloid leukemia, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and multiple myeloma (Polliack, 1991; Cidlowski and Schwartzman, 1993), although they also demonstrate growth suppressive effects on solid tumors (Alexander et al., 1993; Evers et al., 1993). Additionally, they are recommended as adjunct treatment for patients with cancerous complications such as metastatic spinal cord compression and brain metastases (Weissman, 1988; Sorensen et al., 1994). The first report concerning glucocorticoids and cancer was published in 1944 (Heilman and Kendall, 1944). Heilman and Kendall (1944) discovered that corticosterone treatment resulted in regression of a lymphatic tumor that had been transplanted into mice. Shortly after that, Dougherty and White (1945) observed that rat thymi underwent involution in response to injections of adrenal cortical hormones and adrenocorticotropin. Such information was suggestive that hormone treatment might also be useful in treating certain tumors in humans; however, further studies showed that humans did not respond in precisely the same manner to glucocorticoid treatment as mice and rats.

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  1. Jennifer W. Montague
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  2. John A. Cidlowski
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Editors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, 1901 Perdido Street, 70112-1393, New Orleans, LA, USA

    Wayne V. Vedeckis

  2. Stanley S. Scott Cancer Center, 1901 Perdido Street, 70112-1393, New Orleans, LA, USA

    Wayne V. Vedeckis

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© 1996 Birkhäuser Boston

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Montague, J.W., Cidlowski, J.A. (1996). Glucocorticoid Actions on Normal and Neoplastic Lymphocytes: Activation of Apoptosis. In: Vedeckis, W.V. (eds) Hormones and Cancer. Hormones in Health and Disease. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4266-6_18

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  • DOI: https://doi.org/10.1007/978-1-4612-4266-6_18

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