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Modal Developmental Aspects of Schizophrenia Across the Life Span

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The Behavioral High-Risk Paradigm in Psychopathology

Part of the book series: Series in Psychopathology ((PSYCHOPATHOLOGY))

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Abstract

One of the most well-established features of the schizophrenic syndrome is its modal age at onset; namely, late adolescence/early adulthood (Loranger, 1984). Because of the apparent salience of this developmental period for the emergence of psychotic symptoms, researchers in the field have focused a great deal of attention on the psychosocial and biological events that characterize it. A widely held assumption has been that certain unique aspects of this period must be playing a role in triggering the expression of psychotic symptoms. Most recently, with the increasing emphasis on biological origins of psychopathology, several writers have pointed out the potential triggering role of postpubescent maturational events in the central nervous system (Benes, 1989, 1991; Feinberg, 1982–1983; Weinberger, 1987).

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References

  • Abdel-Dayem, H.M., El-Hilu, S., Sehweil, A., Higazi, B., Jahan, S., Salhat, M., & Al-Mohannadi, S. (1990). Cerebral perfusion changes in schizophrenic patients using Tc-99m Hexamethylpropylene Amineoxime (HMPAO). Clinical Nuclear Medicine, 15, 468–472.

    PubMed  Google Scholar 

  • Altshuler, L.L., Conrad, A., Kovelman, J.A., & Scheibel, A. (1987). Hippo- campal pyramidal cell orientation in schizophrenia. Archives of General Psychiatry, 44, 1094–1098.

    PubMed  Google Scholar 

  • Andreasen, N.C., Ehrardt, J.C., Swayze, V.W., Alliger, R.J., Yuh, W.T.C., Cohen, G., & Zeibell, S. (1990). Magnetic resonance imaging of the brain in schizophrenia. Archives of General Psychiatry, 47, 35–44.

    PubMed  Google Scholar 

  • Andreasen, N.C., & Olsen, S. (1982). Negative versus positive schizophrenia. Archives of General Psychology, 39, 789–794.

    Google Scholar 

  • Anzai, N., Okazaki, Y., Miyauchi, M., Harada, S.I., Kanou, Y., Sasaki, T., Kumagai, N., Shikiba, N., Iwanami, A., Iadi, S., Hiramatsu, K.I., Niwa, S.I., & Ohta, M. (1988). Early neuroleptic medication within one year after onset can reduce risk of later relapses in schizophrenic patients. Annual Report Pharmacopsychiatric Research Foundation, 19, 258–265.

    Google Scholar 

  • Aylward, E., Walker, E., & Bettes B. (1984). Intelligence in schizophrenia: Meta-analysis of the research. Schizophrenia Bulletin, 10 (3), 430–459.

    PubMed  Google Scholar 

  • Bardenstein, K.K., & McGlashan, T.H. (1990). Gender differences in affective, schizoaffective and schizophrenic disorders. A review. Schizophrenia Research, 3, 159–172.

    PubMed  Google Scholar 

  • Barthell, C.N., & Holmes, D.S. (1968). High school yearbooks: A nonreactive measure of social isolation in graduates who later became schizophrenic. Journal of Abnormal Psychology, 73 (4), 313–316.

    PubMed  Google Scholar 

  • Benes, F.M. (1989). Myelination of cortical hippocampal relays during late adolescence. Schizophrenia Bulletin, 15, 585–594.

    PubMed  Google Scholar 

  • Benes, F.M. (1991). Toward a neurodevelopmental understanding of schizophrenia and other psychiatric disorders. In D. Cicchetti & S.L. Toth (Eds.), Rochester Symposium on Developmental Psychopathology, 3, 161–184.

    Google Scholar 

  • Bland, H.C., & Orn, H. (1978). 14-year outcome in early schizophrenia. Acta Psychiatrica Scandinavia, 58, 327–338.

    Google Scholar 

  • Bleuler, E. (1950). Dementia praecox or the group of schizophrenias. (J. Zinkin, Trans.). New York: International University Press. ( Original work published, 1911 ).

    Google Scholar 

  • Bleuler, M. (1972). Die Schizophrenen Geistestorungen im Lichte langjährigem Kranken—und Familiengeschichten. Stuttgart: George Thieme.

    Google Scholar 

  • Bleuler, M. (1978). The Schizophrenic Disorders; The Long Term Patient and Family Studies. (S.M. Clemens, Trans.). New Haven: Yale University Press. ( Original work published 1972 ).

    Google Scholar 

  • Bogerts, B., Ashtari, M., Degreff, G., Alvir, J.M., Bilder, R.M., & Lieberman, J.A. (1990). Reduced temporal limbic structure volumes on magnetic resonance images in first episode schizophrenia. Psychiatry Research, 35, 1–13.

    PubMed  Google Scholar 

  • Bracha, H.S., Torrey, E.F., Bigelow, L.B., Lohr, J.B., & Linington, B.B. (1991). Subtle signs of prenatal maldevelopment of the hand ectoderm in schizophrenia: A preliminary monozygotic twin study. Biological Psychiatry, 30, 719–725.

    Google Scholar 

  • Bridge, T.P., Cannon, H.E., & Wyatt, R.J. (1978). Burned-out schizophrenia: Evidence for age effects on schizophrenic symptomatology. Journal of Gerontology, 33, 312–318.

    Google Scholar 

  • Brown, G.W., Birley, J.L.T., & Wing, J.K. (1972). Influence of family life on the course of schizophrenic disorders: A replication. British Journal of Psychiatry, 121, 241–258.

    PubMed  Google Scholar 

  • Cannon, T.D., Mednick, S.A., & Parnas, J. (1990). Antecedents of predominantly negative- and predominantly positive-symptom schizophrenia in a high-risk population. Archives of General Psychiatry, 47, 622–632.

    PubMed  Google Scholar 

  • Cannon-Spoor, E., Potkin, S.G., & Wyatt, R.J. (1982). Measurement of premorbid adjustment in chronic schizophrenia. Schizophrenia Bulletin, 8, 470–484.

    PubMed  Google Scholar 

  • Carpenter, W.T., & Kirkpatrick, B. (1988). The heterogeneity of the long-term course of schizophrenia. Schizophrenia Bulletin, 14, 645–652.

    PubMed  Google Scholar 

  • Carpenter, W.T., Strauss, J.S., Pulver, A.E., & Wolznier, P.S. (1991). The prediction of outcome in schizophrenia: IV. Eleven-year follow-up of the Washington IPSS cohort. Journal of Nervous and Mental Disease, 179 (9), 517–525.

    PubMed  Google Scholar 

  • Casey, D.E., & Hansen, T.E. (1984). Spontaneous dyskinesias. In D.V. Jeste & R.J. Wyatt (Eds.), Neuropsychiatric movement disorders (pp. 68–95 ). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Chugani, H.T. (1992). Development of regional brain glucose metabolism in relation to behavior and plasticity. In G. Dawson & K. Fischer (Eds.), Human behavior and the developing brain (pp. 120–135 ). New York: Guilford Press.

    Google Scholar 

  • Chugani, H.T., Mazziotta, J.C., & Phelps, M.E. (1987). Positron emission tomography study of human brain functional development. Annals of Neurology, 22, 487–497.

    PubMed  Google Scholar 

  • Chugani, H.T., & Phelps, M.E. (1986). Maturational changes in cerebral function in infants determined by 18FDG positron emission tomography. Science, 231, 840–843.

    PubMed  Google Scholar 

  • Ciompi, L. (1980). Catamnestic long-term study on the course of life and aging of schizophrenics. Schizophrenia Bulletin, 6, 606–618.

    PubMed  Google Scholar 

  • Ciompi, L., & Muller, C. (1976). Lebensweg und Alter Schizophrenen eine Katamnestic Longzeitstudie bis ins Senium. Berlin: Springer-Verlag.

    Google Scholar 

  • Coffey, Y.P., & Jessup, W. (1959). Maternal influenza and congenital deformities: A prospective study. Lancet, 2, 935–938.

    PubMed  Google Scholar 

  • Cohen, C.I. (1990). Outcome of schizophrenia into later life: An overview. The Gerontologist, 30 (6), 790–797.

    PubMed  Google Scholar 

  • Cross, A.J., Crow, T.J., & Owen, F. (1981). 3H-Flupenthixol binding in postmortem brains of schizophrenics: Evidence for a selective increase in dopamine D2 receptors. Psychopharmacology, 74, 122–124.

    Google Scholar 

  • Crow, T.J., Johnstone, E.C., Longden, A.J., & Owen, F. (1978). Dopaminergic mechanisms in schizophrenia: The antipsychotic effect and the disease process. Life Sciences, 23, 563–567.

    PubMed  Google Scholar 

  • Crow, T.J., MacMillan, J.F., Johnson, A.L., & Johnstone, E.C. (1986). A randomized controlled trial of prophylactic neuroleptic treatment. British Journal of Psychiatry, 148, 120–127.

    PubMed  Google Scholar 

  • Cummins, H., & Mildo, C. (1943). Fingerprints, palms and soles: An introduction to dermatoglyphics. New York: Dover.

    Google Scholar 

  • Dworkin, R.H., Friedman, R., Kaplansky, L.M., Lewis, J.A., Rinaldi, A., Shilliday, G., Cornblatt, B.A., & Erlenmeyer-Kimling, L. ( 1991, December). Childhood precursors of affective and social deficits in adolescents at risk for schizophrenia. Paper presented at the meeting of the Society for Research in Psychopathology, Cambridge, MA.

    Google Scholar 

  • Dworkin, R.H., Green, S.R., Small, N.E., Warner, M.L., Cornblatt, B.A., & Erlenmeyer-Kimling, L. (1990). Positive and negative symptoms and social competence in adolescents at risk for schizophrenia and affective disorder. Clinical and Research Reports, 147 (9), 1234–1236.

    Google Scholar 

  • Engelhardt, D.M., Rosen, B., Feldman, J., Engelhardt, J.A.Z., & Cohen, P.A. (1982). A 15-year follow-up of 646 schizophrenic outpatients. Schizophrenia Bulletin, 8, 493–503.

    PubMed  Google Scholar 

  • Erlenmeyer-Kimling, L., Marcuse, Y., Cornblatt, B., Friedman, D., Rainer, J.D., & Rutschmann, J. (1984). The New York High-Risk Project. In N.F. Watt, E.J. Anthony, L.C. Wynne, & J. Roff (Eds.), Children at risk for schizophrenia: A longitudinal perspective (pp. 169–189 ). New York: Cambridge University Press.

    Google Scholar 

  • Falkai, P., & Bogerts, B. (1986). Cell loss in the hippocampus of schizophrenics. European Archives of Psychiatry and Neurological Science, 236, 154–161.

    Google Scholar 

  • Feinberg, I. (1982-1983). Schizophrenia: Caused by a fault in programmed synaptic elimination during adolescence. Journal of Psychiatric Research, 17, 319–334.

    Google Scholar 

  • Fenton, W.S., & McGlashan, T.H. (1987). Sustained remission in drug-free schizophrenics. American Journal of Psychiatry, 144, 1306–1309.

    PubMed  Google Scholar 

  • Fish, B., Marcus, J., Hans, S.L., Auerbach, J.G., & Perdue, S. (1992). Infants at risk for schizophrenia: Sequelae of a genetic neurointegrative defect: A review and replication analysis of pandysmaturation in the Jerusalem Infant Development Study. Archives of General Psychiatry, 49, 221–235.

    PubMed  Google Scholar 

  • Freide, R.L. (1989). Developmental neuropathology. Berlin: Springer-Verlag.

    Google Scholar 

  • Gluck, L. (1977). Intrauterine asphyxia in the developing fetal brain. Chicago: Year Book.

    Google Scholar 

  • Goldman-Rakic, P.S. (1987). Development of cortical circuitry and cognitive function. Child Development, 58, 601–622.

    PubMed  Google Scholar 

  • Goldstein, J.M., & Kreisman, D. (1988). Gender, family environment and schizophrenia. Psychological Medicine, 18, 861–872.

    PubMed  Google Scholar 

  • Gossey, S., Golaire, M.C., & Larroche, J.C. (1982). Cerebral, renal, and splenic lesions due to fetal anoxia and their relationship to malformations. Developmental Medicine and Child Neurology, 24, 510–518.

    Google Scholar 

  • Gottesman, I.I. (1991). Schizophrenia genesis. New York: W.H. Freeman.

    Google Scholar 

  • Gur, R.E., Resnick, S.M., Alavi, A., Gur, R.C., Caroff, S., Dann, R., Silver, F.L., Saykin, A.J., Chawluk, J.B., Kushner, M., & Reivich, M. (1987). Regional brain function in schizophrenia: A positron emission tomography study. Archives of General Psychiatry, 44, 119–125.

    PubMed  Google Scholar 

  • Gur, R.E., Resnick, S.M., Gur, R.C., Alavi, A., Caroff, S., Kushner, M., & Reivich, M. (1987). Regional brain function in schizophrenia: Repeated evaluation with positron emission tomography. Archives of General Psychiatry, 44, 126–129.

    PubMed  Google Scholar 

  • Gureje, O. (1988). Topographic subtypes of tardive dyskinesia in schizophrenic patients less than 60 years. Journal of Neurology, Neurosurgery and Psychiatry, 51, 1525–1530.

    Google Scholar 

  • Guttman, E. (1936). On some constitutional aspects of chorea and on its sequela. Journal of Neurology and Psychopathology, 17, 16–26.

    Google Scholar 

  • Hamilton, W.J., Boyd, J.D., & Mossman, H.W. (1972). Human embryology: Prenatal development of form and function. London: Heffer.

    Google Scholar 

  • Hans, S.L., & Marcus, J. (1991). Neurobehavioral development of infants at risk for schizophrenia. In E. Walker (Ed.), Schizophrenia: A life-course developmental perspective (pp. 35 - 53 ). New York: Academic Press.

    Google Scholar 

  • Harding, C.M. (1988). Course types in schizophrenia: An analysis of European and American studies. Schizophrenia Bulletin, 14, 633–643.

    PubMed  Google Scholar 

  • Harding, C.M. (1991). Aging and schizophrenia: Plasticity, reversibility, and/or compensation. In E. Walker (Ed.), Schizophrenia: A life-course developmental perspective (pp. 257–273 ). New York: Academic Press.

    Google Scholar 

  • Harding, C.M., Brooks, G.W., Ashikaga, T., Strauss, J.S., & Breier, A. (1987a). The Vermont longitudinal study of persons with severe mental illness: I. Methodology, study sample, and overall status 32 years later. American Journal of Psychiatry, 144, 718–726.

    PubMed  Google Scholar 

  • Harding, C.M., Brooks, G.W., Ashikaga, T., Strauss, J.S., & Breier, A. (1987b). The Vermont longitudinal study of persons with severe mental illness: II. Long- term outcome for subjects who retrospectively met DSM-III criteria for schizophrenia. American Journal of Psychiatry, 144, 727–735.

    PubMed  Google Scholar 

  • Harper, P.S. (Ed.). (1991). Huntington’s disease. London: W.B. Saunders.

    Google Scholar 

  • Hayashi, M., Satoh, J., Sakamoto, K., & Morimatsu, Y. (1991). Clinical and neuropathological findings in severe athetoid cerebral palsy. Brain and Development, 13, 47–51.

    PubMed  Google Scholar 

  • Heaton, R.K., & Drexler, M. (1987). Clinical neuropsychological findings in schizophrenia and aging. In N.E. Miller & G.D. Cohen (Eds.), Schizophrenia and aging. New York: Guilford Press.

    Google Scholar 

  • Heckers, S., Heinsen, H., Heinsen, Y., & Beckmann, H. (1991). Cortex, white matter, and basal ganglia in schizophrenia: A volumetric postmortem study. Biological Psychiatry, 29, 143–149.

    Google Scholar 

  • Hertzig, M.E., & Birch, H.G. (1966). Neurologic organization in psychiatrically disturbed adolescent girls. Archives of General Psychiatry, 15, 590–598.

    PubMed  Google Scholar 

  • Hess, E.J., Bracha, H.S., Kleinman, J.E., & Creese, I. (1987). Dopamine receptor subtype imbalance in schizophrenia. Life Science, 40, 1487–1497.

    Google Scholar 

  • Huber, G., Gross, G., & Schuttler, R. (1979). Schizophrenie. Verlaufs-und sozialpsychiatrische Langzeitunter-suchungen an den 1945 his 1959 in Bonn hospitalisierten schizophrenen Kranken. Monographien aus dem Gesamtgebiete der Psychiatrie. Bd. 21. Berlin: Springer-Verlag.

    Google Scholar 

  • Huttenlocher, P.R. (1990). Morphometric study of human cerebral cortex development. Neuropsychologia, 28, 517–527.

    PubMed  Google Scholar 

  • Izard, C.E., Dougherty, L.M., & Hembree, E.A. (1983). A System for identifying affect expressions by holistic judgements (AFFEX). Neward, DE: Instructional Resources Center, University of Delaware.

    Google Scholar 

  • Jakob, H., & Beckman, H. (1986). Prenatal development disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmission, 65, 303–326.

    PubMed  Google Scholar 

  • Jernigan, T.L., Zisook, S., Heaton, R.K., Moranville, J.T., Hesselink, J.R., & Braff, D.L. (1991). Magnetic resonance imaging abnormalities in lenticular nuclei and cerebral cortex in schizophrenia. Archives of General Psychiatry, 48, 881–890.

    PubMed  Google Scholar 

  • Jeste, D.V., & Lohr, J.B. (1989). Hippocampal pathologic findings in schizophrenia. Archives of General Psychiatry, 46, 1019–1026.

    PubMed  Google Scholar 

  • Jeste, D.V., & Wyatt R.J. (1987). Aging and tardive dyskinesia. In N. Miller & G. Cohen (Eds.), Schizophrenia and aging (pp. 275–283 ). New York: Guilford Press.

    Google Scholar 

  • John, R.S., Mednick, S.A., & Schulsinger, F. (1982). Teacher reports as a predictor of schizophrenia and borderline schizophrenia: A Bayesian decision analysis. Journal of Abnormal Psychology, 91 (6), 399–413.

    PubMed  Google Scholar 

  • Johnstone, E.C., Crow, T.J., Johnson, A.L., & MacMillan, J.F. (1986). The North wick Park Study of first episodes of schizophrenia: I. Presentation of the illness and problems relating to admission. British Journal of Psychiatry, 148, 115–120.

    PubMed  Google Scholar 

  • Johnstone, E.C., MacMillan, J.F., Frith, C.D., Benn, D.K., & Crow, T.J. (1990). Further investigation of predictors of outcome following first schizophrenic episodes. British Journal of Psychiatry, 157, 182–189.

    PubMed  Google Scholar 

  • Jonsson, H., & Nyman, A.K. (1991). Predicting long-term outcome in schizophrenia. Acta Psychiatrica Scandinavia, 83, 342–346.

    Google Scholar 

  • Kay, S.R., Fiszbein, A., & Opler, A. (1987). The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13 (2), 261–276.

    PubMed  Google Scholar 

  • Kay, S.R., & Murrill, L.M. (1990) Predicting outcome of schizophrenia: Significance of symptom profiles and outcome dimensions. Comprehensive Psychiatry, 31, 91–102.

    PubMed  Google Scholar 

  • Kennard, M.A. (1960). Value of equivocal signs in neurologic diagnosis. Neurology, 10, 753–764.

    PubMed  Google Scholar 

  • Khot, V., & Wyatt, R.J. (1991). Not all that moves is tardive dyskinesia. American Journal of Psychiatry, 148, 661–666.

    PubMed  Google Scholar 

  • Kidger, T., Barnes, T.R.E., Trauer, T., & Taylor, P.J. (1980). Subsyndromes of tardive dyskinesia. Psychological Medicine, 10, 513–520.

    PubMed  Google Scholar 

  • Klawans, H.L. (1988). The pathophysiology of drug-induced movement disorders. In J. Jankonic & E. Tolosa (Eds.), Parkinson’s disease and movement disorder (pp. 315–324 ). Baltimore: Urban and Schagenberg.

    Google Scholar 

  • Klawans, H.L., & Weiner, W.J. (1975). The pharmacology of choreatic movement disorders. In G.A. Kerkut & J.W. Philips (Eds.), Progress in neurobiology (pp. 1–32 ). Oxford, England: Pergamon Press.

    Google Scholar 

  • Knobloch, H., & Pasamanick, B. (1974). Developmental diagnosis. New York: Harper & Row.

    Google Scholar 

  • Konner, M. (1991). Universals of behavioral development in relation to brain myelination. In K. Gibson & A. Peterson (Eds.), Brain maturation and cognitive development (pp. 181–224 ). New York: Aldine De Gruyter.

    Google Scholar 

  • Kovelman, J., & Scheibel, A. (1984). A neurohistological correlate of schizophrenia. Biological Psychiatry, 19, 1601–1621.

    PubMed  Google Scholar 

  • Leck, T. (1963). Incidence of malformations following influenza symptoms. British Journal of Preventative and Social Medicine, 17, 70–73.

    Google Scholar 

  • Lewine, R.R.J. (1991). Ontogenetic implications of Sex Differences in Schizophrenia. In E. Walker (Ed.), Schizophrenia: A life-course developmental perspective. New York: Academic Press.

    Google Scholar 

  • Lewis, & Murray. (1987). Obstetric Complications, neurodevelopmental deviance and risk of schizophrenia. Journal of Psychiatric Research, 21, 413–421.

    PubMed  Google Scholar 

  • Lindenmeyer, J., Kay, S.R., & Opler, L. (1984). Positive and negative subtypes in acute schizophrenia. Comprehensive Paychiatry, 25 (4), 455–464.

    Google Scholar 

  • Loranger, A. (1984). Sex differences in age at onset of schizophrenia. Archives of General Psychiatry, 41, 157–161.

    PubMed  Google Scholar 

  • Lyon, M., Barr, C.E., Cannon, T.D., Mednick, S.A., & Shore, D. (1989). Fetal neural development and schizophrenia. Schizophrenia Bulletin, 15, 149–160.

    PubMed  Google Scholar 

  • Machon, R.A., Mednick, S.A., & Schulsinger, F. (1987). Seasonality, birth complications, and schizophrenia in a high risk sample. British Journal of Psychiatry, 151, 122–124.

    PubMed  Google Scholar 

  • MacMillan, J.F., Gold, A., Crow, T.J., Johnson, A.L., & Johnstone, E.C. (1986). The Northwick Park Study of first episodes of schizophrenia: IV. Expressed emotion and relapse. British Journal of Psychiatry, 148, 133–143.

    PubMed  Google Scholar 

  • Marneros, A., Deister, A., & Rohde, A. (1992). Validity of the negative /positive dichotomy for schizophrenic disorders under long-term conditions. Schizophrenia Research, 7, 117–123.

    PubMed  Google Scholar 

  • McGeer, P.L., McGeer, E.G. (1981). Neurotransmitters in the aging brain. In A.M. Darrison & R.M. Thompson (Eds.), The nolecular basis of neuropathology (pp. 631–648 ). London: Edward Arnold Ltd.

    Google Scholar 

  • McGlashan, T.H. (1984a). The Chestnut Lodge follow-up study: I. Follow-up methodology and study sample. Archives of General Paychiatry, 41, 573–585.

    Google Scholar 

  • McGlashan, T.H. (1984b). The Chestnut Lodge follow-up study: II. Longterm outcome of schizophrenia and the affective disorders. Archives of General Psychiatry, 41, 586–601.

    PubMed  Google Scholar 

  • McGlashan, T.H. (1986). Predictors of shorter-, medium-, and longer-term outcome in schizophrenia. American Journal of Psychiatry, 143, 50–55.

    PubMed  Google Scholar 

  • McGlashan, T.H. (1988). A selective review of recent North American long-term followup studies of schizophrenia. Schizophrenia Bulletin, 14, 515–542.

    PubMed  Google Scholar 

  • McNeil, T.F. (1987). Perinatal influences in the development of schizophrenia. In H. Helmehen & F.A. Henn (Eds.), Biological perspective of schizophrenia. (pp. 125–138 ).

    Google Scholar 

  • McNeil, T.F., & Kaij, L. (1978). Obstetric factors in the development of schizophrenia: Complications in the births of preschizophrenice and in reproduction by schizophrenic parents. In L.C. Wynne, R.L. Cromwell, & S. Matthysee (Eds.), The nature of schizophrenia (pp. 401–429 ), New York: John Wiley and Sons Limited.

    Google Scholar 

  • Mednick, S., Machon, R.A., Huttunen, M.O., & Bonnett, D. (1988). Adult schizophrenia following prenatal exposure to an influenza epidemic. Archives of General Psychiatry, 45, 15–23.

    Google Scholar 

  • Mednick, S.A., & Schulsinger, F. (1965). A longitudinal study of children with a high risk for schizophrenia: A preliminary report. In S. Vandenberg (Ed.), Methods and goals in human behavior genetics (pp. 255–296 ). New York: Academic Press.

    Google Scholar 

  • Miller, N.E., & Cohen, G.D. (Eds.) (1987). Schizophrenia and Aging. New York: The Guilford Press.

    Google Scholar 

  • Narabayashi, H. (1989). Striatal symptoms. Stereotactic Functional Neurosurgery, 52, 200–204.

    Google Scholar 

  • Newell-Morris, L.L., Fahrenbruch, C.E., Sackett, G.P. (1989). Prenatal psychological stress, dermatoglyphic asymmetry and pregnancy outcome in the pigtailed macaque (Macaca nemestrina). Biology of the Neonate, 56, 61–75.

    PubMed  Google Scholar 

  • O’Callaghan, E., Sham, P., Takei, N., Glover, G., & Murray, R.M. (1991). Schizophrenia after prenatal exposure to 1957 A2 influenza epidemic. Lancet, 337, 1248–1250.

    PubMed  Google Scholar 

  • Obrist, W.D. (1980). Cerebral blood flow and EEG changes associated with aging and dementia. In E.W. Busse & D.G. Blazer (Eds.), Handbook of geriatric psychiatry (pp. 83–101 ). New York: Van Nostrand Reinhold.

    Google Scholar 

  • O’Gureje, O. (1989). Correlates of positive and negative schizophrenic syndromes in Nigerian patients. British Journal of Psychiatry, 155, 628–632.

    Google Scholar 

  • Ojordsmoen, S. (1991). Long-term clinical outcome of schizophrenia with special reference to gender differences. Acta Psychiatrica Scandinavia, 83, 307–313.

    Google Scholar 

  • Opler, L.A., Kay, S.R., Rosado, V., & Lindenmeyer, J. (1984). Positive and negative syndromes in chronic schizophrenic inpatients. Journal of Nervous and Mental Disease, 172 (6), 317–324.

    PubMed  Google Scholar 

  • Parnas, J., Schulsinger, F., Teasdale, T.W., Schulsinger, H., Feldman, P.M., & Mednick, S.A. (1982). Perinatal complications and clinical outcome with the schizophrenia spectrum. British Journal of Psychiatry, 340, 416–420.

    Google Scholar 

  • Pogue-Guile, M.F., & Harrow, M. (1984). Negative and positive symptoms in schizophrenia and depression: A follow-up. Schizophrenia Bulletin, 10 (3), 371–387.

    Google Scholar 

  • Pogue-Guild, M.F., & Harrow, M. (1985). Negative symptoms in schizophrenia: Their longitudinal course and prognostic importance. Schizophrenia Bulletin, 11 (3), 427–439.

    Google Scholar 

  • Rabiner, C.J., Wegner, J.T., & Kane, J.M. (1986). Outcome study of first episode psychosis: I. Relapse rate after one year. American Journal of Psychiatry, 143, 1155–1158.

    PubMed  Google Scholar 

  • Rakic, P. (1988). Defects of neuronal migration and the pathogenesis of cortical malformations. Progress in Brain Research, 73, 15–35.

    PubMed  Google Scholar 

  • Ram, R., Bromet, E.J., Eaton, W., Pato, E.C., & Schwartz, J.E. (1992). The natural course of schizophrenia: A review of first-admission studies. Schizophrenia Belletin, 18, 185–207.

    Google Scholar 

  • Rappaport, M., Hopkins, H.K., Hall, K., Belleza, T., & Silverman, J. (1978). Are there schizophrenics for whom drugs may be unnecessary of contrain- dicated? International Pharmacopsychiatry, 13, 100–111.

    PubMed  Google Scholar 

  • Reich, J., & Thompson, W.D. (1985). Marital status of schizophrenic and alcoholic patients. The Journal of Nervous and Mental Disease, 173, 499–502.

    PubMed  Google Scholar 

  • Reither, P.J. (1926). Extrapyramidal motor-disturbances in dementia praecox. Acta Psychiatrica et Neurologica Scandinavien, 1, 287–309.

    Google Scholar 

  • Resnick, S.M., Gur, R.E., Alavi, A., Gur, R.C., & Reivich, M. (1988). Positron emission tomography and subcortical glucose metabolism in schizophrenia. Psychiatry Research, 24, 1–11.

    PubMed  Google Scholar 

  • Reynolds, G.P. (1983). Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature, 305, 527–529.

    PubMed  Google Scholar 

  • Rochford, J.M., Detre, T., Tucker, G.J., & Harrow, M. (1970). Neuropsychological impairments in functional psychiatric diseases. Archives of General Psychiatry, 22, 114–119.

    PubMed  Google Scholar 

  • Roff, J.D., Knight, R., & Wertheim, E. (1976). A factor-analytic study of childhood symptoms antecedent to schizophrenia. Journal of Abnormal Psychology, 85 (6), 543–549.

    PubMed  Google Scholar 

  • Rupp, C., & Fletcher, E.K. (1940). A five to ten year follow-up study of 641 schizophrenic cases. American Journal of Psychiatry, 96, 877–888.

    Google Scholar 

  • Saint-Anne Dargassies, S. (1982). The neuromotor and psychoaffective development of the infant. Amsterdam, the Netherlands: Elsevier.

    Google Scholar 

  • Salokangas, R.K.R. (1983). Prognostic implications of the sex of schizophrenic patients. British Journal of Psychiatry, 142, 145–151.

    PubMed  Google Scholar 

  • Saugstad L. (1989). Social class, marriage and fertility in schizophrenia. Schizophrenia Bulletin, 15, 9–44.

    PubMed  Google Scholar 

  • Schaumann, B., & Alter, A. (1976). Dermatoglyphics in medical disorders. New York: Springer-Verlag.

    Google Scholar 

  • Schwarzkopf, S., Nasrallah, A., Olson, S.C., Coffman, J., & Mclaughlin, J. (1988). Perinatal complications and genetic loading in schizophrenia: Preliminary findings. Psychiatry Research, 27, 233–239.

    Google Scholar 

  • Scottish Schizophrenia Research Group. (1988). The Scottish first episode schizophrenia study: V. One year follow-up. British Journal of Psychiatry, 152, 470–476.

    Google Scholar 

  • Seeman, M.V. (1983). Interaction of sex, age, and neuroleptic dose. Comprehensive Psychiatry, 24, 125–128.

    PubMed  Google Scholar 

  • Seeman, M.V., & Hauser, P. (1984). Schizophrenia: The influence of gender on family environment. International Journal of Family Psychiatry, 5, 227–232.

    Google Scholar 

  • Seeman, P., Bzowej, N.H., Guan, H.C., Bergeron, C., Reynolds, G.P., Bird, E.D., Riederer, P., Jellinger, K., & Tourtellotte, W.W. (1987). Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer’s, Parkinson’s, and Huntington’s diseases. Neuropsychopharmacology, 1, 5–15.

    PubMed  Google Scholar 

  • Stengel, T.J., Attermeier, S.M., Bly, L., & Heriza, C.B. (1984). Evaluation of sensorimotor dysfunction. In S.K. Campbell (Ed.), Pediatric neurologic physical therapy (pp. 13–81 ). New York: Churchill Livingstone.

    Google Scholar 

  • Stevens, J.H. (1978). Long-term prognosis and followup in schizophrenia. Schizophrenia Bulletin, 4, 25–47.

    Google Scholar 

  • Stevens, J.H., & Astrup, C. (1963). Prognosis in “process” and “nonprocess” schizophrenia. American Journal of Psychiatry, 119, 945–953.

    Google Scholar 

  • Stevens, J.H., Astrup, C., & Mangrum, J.C. (1966). Prognostic factors in recovered and deteriorated schizophrenics. American Journal of Psychiatry, 122, 1116–1121.

    Google Scholar 

  • Suddath, R.L., Christison, G.W., Torrey, E.F., Casanova, M.F., & Weinberger, D.R. (1990). Anatomical abnormalities in the brains of monozygotic twins discordant for schizophrenia. New England Journal of Medicine, 332, 789–794.

    Google Scholar 

  • Tamminga, C.A., Thaker, G.K., Buchanan, R., Kirkpatrick, B., Alphs, L.D., Chase, T.N., & Carpenter, W.T. (1992). Limbic system abnormalities identified in schizophrenia using positron emission tomography with fluorodeoxyglucose and neocortical alterations with deficit syndrome. Archives of General Psychiatry, 49, 522–530.

    PubMed  Google Scholar 

  • Test, M.A., Burke, S.S., & Wallisch L.S. (1990). Gender differences of young adults with schizophrenic disorders in community care. Schizophrenia Bulletin, 16 (2), 331–344.

    PubMed  Google Scholar 

  • Toru, M., Watanabe, S., Shibuya, H., Nishikawa, T., Noda, K., Mitsushio, H., Ichikawa, H., Kurumaji, A., Takaskhima, M., Mataga, N., & Ogawa, A. (1988). Neurotransmitters, receptors and neuropeptides in post-mortem brains of chronic schizophrenic patients. Acta Psychiatrica Scandinavica, 78, 121–137.

    PubMed  Google Scholar 

  • Towbin, A. (1986). Obstetric malpractice litigation: The pathologist’s view. American Journal of Obstetrics and Gynecology, 155, 927–935.

    PubMed  Google Scholar 

  • Tsuang, M.T., & Winokur, G. (1975). The Iowa 500: Field work in a 35 year follow-up of depression, mania, and schizophrenia. Canadian Psychiatric Journal, 20, 389.

    Google Scholar 

  • Tsuang, M.T., Woolson, R.F., & Fleming, J.A. (1979). Long-term outcome of major psychosis: I. Schizophrenia and affective disorders compared with psychiatrically symptom-free surgical conditions. Archives of General Psychiatry, 39, 1295–1301.

    Google Scholar 

  • Ulloa-Aguirre, A., Tarraso, J., Mendez, J.P., Garza-Flores, J., Diaz-Sanchez, V., & Perez-Palacios, G. (1991). Changes in the responsiveness of prolactin secretion to depaminergic blockade and TRH stimulation throughout sexual maturation in men. Psychoneuroendocrinology, 15, 279–286.

    Google Scholar 

  • Vaillant, G.E. (1964a). An historical review of the remitting schizophrenias. Journal of Nervous and Mental Diseases, 138, 48–56.

    Google Scholar 

  • Vaillant, G.E. (1964b). Prospective prediction of schizophrenic remission. Archives of General Psychiatry, 11, 509–518.

    PubMed  Google Scholar 

  • Vaughn, C., & Leff, J. (1976). The influence of family and social functions on the course of psychiatric illness. British Journal of Psychiatry, 129, 125–137.

    PubMed  Google Scholar 

  • Vaughn, C.E., Snyder, K.S., Jones, S., Freeman, W.B., & Falloon, R.H. (1984). Family factors in schizophrenic relapse: Replication in California of British research on expressed emotion. Archives of General Psychiatry, 41, 1169–1177.

    PubMed  Google Scholar 

  • Virtunski, P.B., Simpson, D.M., & Meltzer, H.Y. (1989) Voluntary movement dysfunction in schizophrenia. Biological Psychiatry, 25, 529–539.

    Google Scholar 

  • Waddington, J.L., & Youssef, H.A. (1990). The lifetime outcome and involuntary movements of schizophrenia never treated with neuroleptic drugs: Four rare cases in Ireland. British Journal of Psychiatry, 156, 106–108.

    PubMed  Google Scholar 

  • Wakita, Y., Narahara, K., & Kimoto, H. (1988). Multivariate analysis dermato- glyphics of severe mental retardates: An application of the constellation in graphical method for discriminate analysis. Acta Med Okayama, 42, 159–168.

    PubMed  Google Scholar 

  • Walker, E., & Emory, E. (1981). Infants at risk for psychopathology: Offspring of schizophrenic parents. Child Development, 54, 1269–1285.

    Google Scholar 

  • Walker, E., Grimes, K., Davis, D., & Smith, A. (1993). Childhood precursors of schizophrenia: Facial expressions of emotion. American Journal of Psychiatry, 150, 1654–1660.

    PubMed  Google Scholar 

  • Walker, E., & Lewine, R. (1988). The positive/negative symptom distinction in schizophrenia: Validity and etiological relevance. Schizophrenia Research, 1, 315–328.

    PubMed  Google Scholar 

  • Walker, E., Lucas, M., & Lewine, R. (1992). Schizophrenic disorders. In A. Puente & R. McCaffrey (Eds.), Handbook of neuropsychological assessment: A biopsychosocial perspective (pp. 309–334 ). New York: Plenum Press.

    Google Scholar 

  • Walker, E., Savoie, T., & Davis, D. (1994). Neuromotor precursors of schizophrenia. Schizophrenia Bulletin, 20, 441–452.

    PubMed  Google Scholar 

  • Waring, E.M., Lefese, D.H., Carver, C., Barnes, S., Fry, R., & Abraham, B. (1988). The course and outcome of early schizophrenia. The Psychiatric Journal of the University of Ottawa, 13, 194–197.

    Google Scholar 

  • Watt, D.C., Katz, K., & Shepherd, M. (1983). The natural history of schizophrenia: A 5-year prospective followup of a representative sample of schizophrenics by means of a standardized clinical and social assessment. Psychological Medicine, 13, 663–670.

    PubMed  Google Scholar 

  • Watt, N.F. (1978). Patterns of childhood social development in adult schizophrenics. Archives of General Psychiatry, 35, 160–165.

    PubMed  Google Scholar 

  • Watt, N.F., Grubb, T.W., & Erlenmeyer-Kimling, L. (1984). Social, emotional, and intellectual behavior at school among children at high risk for schizophrenia. In N.F. Watt, J. Anthony, L.C. Wynne, & J.E. Rolf (Eds.), Children at risk for schizophrenia (pp. 212–226 ). New York: Cambridge University Press.

    Google Scholar 

  • Wattie, B.J.S., & Kedward, H.B. (1985). Gender differences in living conditions found among male and female schizophrenic patients on a follow-up study. International Journal of Social Psychiatry, 31, 205–216.

    PubMed  Google Scholar 

  • Weggmann, T., Brown, J.K., Fulford, G.E., & Minns, R.A. (1987). A study of normal baby movements. Child: Care, Health, and Development, 13, 41–58.

    Google Scholar 

  • Weinberger, D. (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660–669.

    PubMed  Google Scholar 

  • Wilcox. J.A. (1990). Thought disorder and relapse in schizophrenia. Pscyhopathology, 23, 153–156.

    Google Scholar 

  • Wilcox, J.A., & Nasrallah, H.A. (1987). Perinatal distress and prognosis of psychotic illness. Neuropsychobiology, 17, 173–175.

    PubMed  Google Scholar 

  • Winblad, B., Hardy, J., Backman, L., & Nilsson, L.G. (1985). Memory function and brain biochemistry in normal aging and in senile dementia. Annals of the New York Academy of Science, 444, 255–268.

    Google Scholar 

  • Winokur, G., Pfohl, B., & Tsuang, M. (1987). A 40-year follow-up of hebephrenic- catatonic schizophrenia. In N.E. Miller & G.D. Cohen (Eds.), Schizophrenia and aging. New York: Guilford Press.

    Google Scholar 

  • Wong, D.F., Wagner, H.N., Jr., Tune, L.E., Dannals, R.F., Pearlson, G.D., Links, J.M., Tamminga, C.A., Brosusolle, E.P., Ravert, H.T., Wilson, A.A., Toung, J.K.T., Malat, J., Williams, J.A., O’Tuama, L.A., Snyder, S.H., Kuhar, M.J., & Gjedde, A. (1986). Positron emission tomography reveals elevated D2 dopamine receptors in neuroleptic-naive schizophrenics. Science, 234, 1558–1563; correction (1987) 235, 623.

    Google Scholar 

  • Wyatt, N. (1991). Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin, 17, 325–351.

    PubMed  Google Scholar 

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Authors
  1. Elaine Walker
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  2. Dana Davis
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  3. Jay Weinstein
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  4. Tammy Savoie
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  5. Kathleen Grimes
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  6. Kym Baum
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Editor information

Editors and Affiliations

  1. Department of Psychology, University of Illinois at Urbana-Champaign, 603 East Daniel Street, Champaign, IL, 61820, USA

    Gregory A. Miller Ph.D. (Professor of Psychology and Psychiatry) (Professor of Psychology and Psychiatry)

  2. Department of Psychiatry, University of Illinois at Urbana-Champaign, 603 East Daniel Street, Champaign, IL, 61820, USA

    Gregory A. Miller Ph.D. (Professor of Psychology and Psychiatry) (Professor of Psychology and Psychiatry)

  3. Department of Beckman Institute, University of Illinois at Urbana-Champaign, 603 East Daniel Street, Champaign, IL, 61820, USA

    Gregory A. Miller Ph.D. (Professor of Psychology and Psychiatry) (Professor of Psychology and Psychiatry)

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Walker, E., Davis, D., Weinstein, J., Savoie, T., Grimes, K., Baum, K. (1995). Modal Developmental Aspects of Schizophrenia Across the Life Span. In: Miller, G.A. (eds) The Behavioral High-Risk Paradigm in Psychopathology. Series in Psychopathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-4234-5_4

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