Introduction: Understanding Blood Vessel Assembly in the Embryo

  • Charles D. Little
Part of the Cardiovascular Molecular Morphogenesis book series (CARDMM)


As we approach the end of the 1900s we are rediscovering the elegant embryology that flourished at the beginning of the century. Modern developmental biologists are beginning to place earlier embryological studies on a firm cellular and molecular basis. Sophisticated probes for specific molecules have stimulated a renaissance in the use of the light microscope. Fluorescent markers, digital image processing, and intravital labeling methods have had a major affect on understanding vascular morphogenesis. Targeted mutation of genes related to vascular development in mice bring the powerful tools of molecular biology to bear on understanding assembly of the vascular system. Recent progress is so rapid that keeping up with the latest discoveries is difficult.


TIE2 Receptor Developmental Biologist Muscle Cell Precursor Arch Artery Cardiac Neural Crest 
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  1. DeRuiter, M.C., Poelmann, R.E., VanMunsteren, J.C., Mironov, V., Markwald, R.R., and Gittenberger-de Groot. Embryonic Endothelial Cells Transdifferentiate into Mesenchymal Cells Expressing Smooth Muscle Actins In Vivo and In Vitro. Circ. Res. 80:444–451, 1997.PubMedGoogle Scholar
  2. Hungerford, J.E., Owens, G.K., Argraves, W.S., and Little, C.D. Development of the Vessel Wall as Defined by Vascular Smooth Muscle and ECM Markers. Dev. Biol. 178:375, 1996.PubMedCrossRefGoogle Scholar
  3. Hungerford, J.E., Hoeffler, J.R, Bowers, C.W., Dahm, L.M., Falchetto, R., Shabanowitz, J., Hunt, D.E, and Little, C.D. Identification of a Novel Marker for Pirmordial Smooth Muscle and Its Differential Expression Pattern in Contractile Versus Noncontractile Cells. J. Cell Biol. 137:925–937, 1997.PubMedCrossRefGoogle Scholar
  4. Lee, S.H., Hungerford, J.E., Little, C.D., and Iruela-Arispe, M.L. Proliferation and Differentiation of Smooth Muscle Cell Precursors Occurs Simultaneously During Development of the Vessel Wall. In press.Google Scholar
  5. Mikawa, T., and Gourdie, R.G. Pericardial Mesoderm Generates a Population of Coronary Smooth Muscle Cells Migrating into the Heart Along with Ingrowth of the Epicardial Organ. Dev. Biol. 174:221–232, 1996.PubMedCrossRefGoogle Scholar
  6. Sato, T.N., Tozawa, Y., Deutsch, U., Wolburg-Buchholz, K., Fujiwara, Y., Gendron-Maguire, M., Gridley, T., Wolburg, H., Risau, W., and Qin, Y. Nature 376(6535):70–74, 1995.PubMedCrossRefGoogle Scholar
  7. Suri, C., Jones, P.F., Patan, S., Bartunkova, S., Maisonpierre, PC., Davis, S., Sato, T.N., and Yancopoulos, G.D. Requisite Role of Angiopoietin-1, A Ligand for the TIE2 Receptor, During Embryonic Angiogenesis. Cell 87:1171–1180, 1996.PubMedCrossRefGoogle Scholar
  8. Topouzis, S., and Majesky, M.W. Smooth Muscle Lineage Diversity in the Chick Embryo. Dev. Biol. 178:430–445, 1996.CrossRefGoogle Scholar
  9. Waldo K.L., Kumiski D., and Kirby M.L. Cardiac Neural Crest is Essential for the Persistence Rather than the Formation of an Arch Artery. Dev. Dyn. 205:281–292, 1996.PubMedCrossRefGoogle Scholar

Copyright information

© Birkhäuser 1996

Authors and Affiliations

  • Charles D. Little
    • 1
  1. 1.Department of Cell Biology and AnatomyMedical University of South CarolinaCharlestonUSA

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