Isoform-Specific Metabolism of Apolipoprotein E: Implications for Alzheimer ’s Disease
Inheritance of specific apolipoprotein E alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease (AD) (see Strittmatter and Roses, 1995). The mechanism by which the apolipoprotein E isoforms differentially contribute to disease expression is, however, unknown. Many isoform-specific interactions of apolipoprotein E have been identified. Identification of isoform-specific interactions of apolipoprotein E give rise to testable hypotheses for the mechanism of pathogenesis of AD. An unresolved issue of increasing importance is the relationship between the structural pathological lesions and the cellular pathogenesis responsible for the clinical disease phenotype, progressive dementia.
KeywordsCholesterol Dementia Cysteine Adduct Serine
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