Inflammatory Processes — Anti-Inflammatory Therapy
Histopathologic studies suggest that inflammatory processes are active at sites of neurodegeneration in Alzheimer’s disease (AD) (see Aisen and Davis, 1994). Acute phase proteins such as a-1 antichymotrypsin (ACT), a-2 macroglobulin and C-reactive protein (CRP) are components of plaques. Interleukins 1 and 6, inflammatory cytokines with the capacity to stimulate expression of acute phase proteins, are present in increased amounts. In addition, early components of the complement cascade are found in the region of neuritic plaques. The cellular component of the inflammatory reaction in the AD brain appears to be the activated microglial cell. These cells bear HLA surface markers, and appear to be closely related to, perhaps derived from, blood-borne mononuclear phagocytes. Activated microglia seem to be involved in the maturation of neuritic plaques.
KeywordsFamilial Mediterranean Fever Amyloid Precursor Protein Acute Phase Protein Neuritic Plaque Amyloid Precursor Protein Processing
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