Preclinical Pharmacology of Metrifonate: A Promise for Alzheimer Therapy
Among the multiple transmitter deficits which have been described in Alzheimer’s Disease (AD), the degeneration of brain cholinergic cell bodies is the most sensitive, specific and severe, as indicated by the good correlation between the cholinergic pathology and dementia. Therefore, current drug development strategies in AD therapy focus on the enhancement of cholinergic neurotransmission. The most advanced class of compounds in this respect are cholinesterase (ChE) inhibitors which aim to restore the concentration of acetylcholine (ACh) in the synaptic cleft.
KeywordsCholinesterase Inhibition Subchronic Administration Dimethyl Phosphate Oxime Therapy Dichlorovinyl Dimethyl Phosphate
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