Abstract
While the etiology of Alzheimer’s disease (AD) is unknown, one of the primary histopathological features of the disease is the accumulation in brain of extracellular deposits of the peptide ß-amyloid (ß-A4). This peptide is produced by the proteolytic processing of the larger precursor protein ß-amyloid precursor protein (ß-APP).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Higgins LS, Catalano R, Quon D and Cordell B (1993): Transgenic mice expressing human ß-APP-751 but not mice expressing ß-APP 695, display early Alzheimer’s disease-like pathology. Ann NY Acad Sci 695: 224–227.
Higgins LS, Holtzman DM, Rabin J, Mobley WC and Cordell B (1994): Transgenic mouse brain histopathology resembles early histopathology. Ann of Neurol 35: 598–607.
Moran PM, Higgins LS, Cordell B and Moser PC (1995): Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human ß-amyloid precursor protein. Proc Natl Acad Sci 92:5341–5345.
Perry TA, Torres E, Czech C, Beyreuther K, Richards SJ and Dunnett SB (1995): Cognitive and motor function in transgenic mice carrying excess copies of the 695 and 751 amino acid isoforms of the amyloid precursor protein gene. Alz Res 1:5–14.
Quon D, Wang Y, Catalano R, Marian Scardina J, Murakami K and Cordell B (1991): Formation of ß-amyloid protein deposits in brains of transgenic mice. Nature 352:239–241.
Yamaguchi F, Richards SJ, Beyreuther K, Salbaum M, Carlson SA and Dunnett SB (1991): Transgenic mice for the amyloid precursor protein 695 isoform have impaired spatial memory. Neuroreport 2:781–784.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Birkhäuser Boston
About this chapter
Cite this chapter
Moran, P.M., Moser, P.C., Higgins, L.S., Cordell, B. (1997). β-App-751 Transgenic Mice: Deficits in Learning and Memory. In: Becker, R.E., Giacobini, E., Barton, J.M., Brown, M. (eds) Alzheimer Disease. Advances in Alzheimer Disease Therapy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4116-4_23
Download citation
DOI: https://doi.org/10.1007/978-1-4612-4116-4_23
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4612-8660-8
Online ISBN: 978-1-4612-4116-4
eBook Packages: Springer Book Archive