Abstract
Recent advances in understanding the action of growth factors on neurons have provided the opportunity for development of new strategies treatment of Alzheimer’s disease (AD) (Hefti, 1994; Tuszynski and Gage, 1994). Since the original description of nerve growth factor (NGF) by Levi-Montalcini et al. (1995), the immutability of the mature central nervous system has been successfully challenged. The number of growth factors affecting neuronal cells has expanded from NGF to include brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), neurotrophin-4/5 (NT-4/5), fibroblast growth factor (FGF), glial cell line-derived neurotrophic factor (GDNF) and insulinlike growth factors (IGF).
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© 1997 Birkhäuser Boston
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Glasky, A.J., Ritzmann, R.F., Rathbone, M.P., Middlemiss, P.J., Crocker, C. (1997). Neurotrophins, Growth Factors and Mimetic Agents as Neuroprotectors in the Treatment of Alzheimer’s Disease. In: Becker, R.E., Giacobini, E., Barton, J.M., Brown, M. (eds) Alzheimer Disease. Advances in Alzheimer Disease Therapy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4116-4_19
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DOI: https://doi.org/10.1007/978-1-4612-4116-4_19
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