Abstract
Alzheimer’s disease (AD) is the most common form of dementia in adults. It determines a progressive loss of intellectual function and appears both sporadically and in an autosomal dominant (familial) form. Presently there is no treatment for AD.
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Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC et al. (1993): Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer’s disease in late onset families. Science 261:921–923
Kindy MS, King AR, Perry G, De Beer MC and De Beer FC (1995): Association of apolipoprotein E with murine amyloid A protein amyloid. Lab Invest 73:469–475.
Kisilevsky R, Lemieux LJ, Fraser PE, Kong X, Hultin PG et al. (1995): Arresting amyloidosis in vivo using small-molecule anionic sulphonates or sulphates: implications for Alzheimer’s disease. Nature Med 1:143–148.
Lorenzo A and Yankner BA (1994): Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91:12243–12247.
Ma J, Yee A, Brewer HB, Jr., Das S and Potter H (1994): Amyloid-associated proteins alpha 1-antichymotrypsin and apolipoprotein E promote assembly of Alzheimer beta-protein into filaments. Nature 372:92–94.
Maggio JE, Stimson ER, Ghilardi J, Allen CJ, Dahl CE et al. (1992): Reversible in vitro growth of Alzheimer’s disease β-amyloid plaques by deposition of labeled amyloid peptide. Proc Natl Acad Sci USA 89:5462–5466.
Matsubara E, Soto C, Governale S, Frangione B and Ghiso J (1996): Apolipoprotein J and Alzheimer amyloid solubility. Biochem J (In Press)
Merlini G, Ascari E, Amboldi N, Belloti V, Arbustini E et al. (1995): Interaction of the anthracycline 4’-iodo-4’-deoxydoxorubicin with amyloid fibrils: Inhibition of fibrillogenesis. Proc Natl Acad Sci USA 92:2959–2964.
Naslund J, Thyberg J, Tjernberg LO, Wernstedt C, Karlstrom AR et al. (1995): Characterization of stable complexes involving apolipoprotein E and the amyloid beta peptide in Alzheimer’s disease brain. Neuron 15:219–228.
Pike CJ, Burdick D, Walencewicz AJ, Glabe CG and Cotman CW (1993): Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 13:1676–1687.
Sisodia SS and Price DL (1995): Role of the β-amyloid protein in Alzheimer’s disease. FASEB J 9:366–370.
Snow AD, Bramson R, Mar H, Wight TN and Kisilevsky R (1991): A temporal and ultrastructural relationship between heparan sulphate proteoglycans and AA amyloid in experimental amyloidosis. J Histochem Cytochem 39:1321–1330.
Soto C, Castaño EM, Frangione B and Inestrosa NC (1995): The alpha-helical to beta-strand transition in the amino-terminal fragment of the amyloid beta-peptide modulates amyloid formation. J Biol Chem 270:3063–3067.
Soto C, Golabek AA, Wisniewski T and Castaño EM (1996): Amyloid β-peptide is conformationally modified by apolipoprotein E in vitro. Neuroreport (In Press)
Wisniewski T, Castaño EM, Golabek A, Vogel T and Frangione B (1994a): Acceleration of Alzheimer’s fibril formation by apolipoprotein E in vitro. Am J Pathol 145:1030–1035.
Wisniewski T, Ghiso J and Frangione B (1994b): Alzheimer’s disease and soluble A. Neurobiol Aging 15:143–152.
Wisniewski T, Lalowski M, Golabek A, Vogel T and Frangione B (1995): Is Alzheimer’s disease an apolipoprotein E amyloidosis? Lancet 345:956–958.
Wisniewski T and Frangione B (1992): Apolipoprotein E: a pathological chaperone protein in patients with cerebral and systemic amyloid. Neurosci Lett 135:235–238.
Wood JD, Wetzel R, Martin JD and Hurle MR (1995): Prolines and amyloidogenicity in fragments of the Alzheimer’s peptide β/A4. Biochem 34:724–730.
Wouters MA and Curmi PMG (1994): An analysis of side chain interactions and pair correlations within antiparallel beta-sheets: the differences between backbone hydrogen-bonded and non-hydrogen bonded residue pairs. Protein Sci 3:43S.
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© 1997 Birkhäuser Boston
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Soto, C., Prelli, F., Frangione, B., Kindy, M.S., de Beer, F. (1997). Peptides Inhibitor of Amyloidogenesis in Alzheimer’s Disease. In: Becker, R.E., Giacobini, E., Barton, J.M., Brown, M. (eds) Alzheimer Disease. Advances in Alzheimer Disease Therapy. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4116-4_15
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DOI: https://doi.org/10.1007/978-1-4612-4116-4_15
Publisher Name: Birkhäuser Boston
Print ISBN: 978-1-4612-8660-8
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