Abstract
Results from our and other laboratories indicate that while cell-free O2 carriers based on modifications of the hemoglobin molecule do carry O2 in vivo when they are used to replace blood or restitute blood volume, the maintained or increased O2 content does not lead to a corresponding maintained or increased O2 delivery due to effects that appear to be of vasoactive origin. As a consequence, the full benefit of the O2 carrier is not realized, and in many instances results are similar to those obtained with blood volume restitution with non-oxygen carrying plasma expanders. This paradox, which must be understood and resolved if efficacy is to be established, is likely to arise from events that develop in the microcirculation when comparatively large amounts of hemoglobin are introduced in the circulation.
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© 1996 Birkhäuser Boston
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Tsai, A.G., Kerger, H., Intaglietta, M. (1996). Microvascular Oxygen Distribution: Effects Due to Free Hemoglobin in Plasma. In: Winslow, R.M., Vandegriff, K.D., Intaglietta, M. (eds) Blood Substitutes. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4114-0_8
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DOI: https://doi.org/10.1007/978-1-4612-4114-0_8
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