Abstract
Glucose homeostasis in the postabsorptive state is affected by fa and cp mutations in the rat.1,2 The fatty (fa)3 and corpulent (cp)4,5 genes are recessive rat mutations that cause obesity. Interbreeding of heterozygous lean Zucker rats, carrying the fa mutation, and Koletsky rats, carrying the cp mutation, produced obese F1 progeny at a 3:1 lean:obese ratio.6 These obese interstrain rats appeared to confirm that fa and cp are mutations of the same gene, but that conclusion has not been confirmed by molecular genetic analysis. Also, metabolic characteristics of the fa cp obese hybrids have not been reported.
Deceased on May 27, 1995
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Kahle, E.B., Butz, K.G., Leibel, R.L., Hansen, C.T., Bhathena, S.J., Michaelis, O.E. (1996). Glucose homeostasis in three interstrains (LA/N-BN/Crl cp/cp; Zuc13M-BN/Crl fa/fa; and Zuc13m-LA/N fa/cp) of genetically obese rats. In: Shafrir, E. (eds) Lessons from Animal Diabetes VI. Rev.Ser.Advs.Research Diab.Animals (Birkhäuser), vol 6. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4112-6_23
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DOI: https://doi.org/10.1007/978-1-4612-4112-6_23
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