Viral-Chemical Combination Effects in Tumorigenesis

  • Yin-tak Woo

Abstract

Shortly after the discovery of the first tumor virus by Rous (1) in 1911 and the first experimental demonstration of chemical induction of cancer in rabbit skin by painting coal tar by Yamagiwa and Ichikawa (2) in 1915, Rous and Kidd (3, 4) reported that tar enhanced the carcinogenic activity of the Shope papillomavirus for the rabbit skin. Since then, numerous reports of interaction between viruses and chemical carcinogens have been published (revs. 5–15) with the majority of these showing synergism. These findings have attracted increasing attention as evidence is mounting that human populations are often exposed to both viruses and chemical carcinogens and that the high incidence of human cancer in certain geographic areas can be attributed to viral-chemical synergistic action. The focus of this section is to review studies indicative of viral-chemical interaction in tumorigenesis in humans, experimental animals, and cell culture systems.

Keywords

Hepatitis Lymphoma Leukemia Adenoma PAHs 

Abbreviations Used

AFB1

aflatoxin B1

ATL

adult T-cell leukemia

BaP

benzo[α]pyrene

BL

Burkitt’s lymphoma

BPV

bovine papillomavirus

CRPV

cottontail rabbit papillomavirus

DEN

diethylnitrosamine

DHBV

duck hepatitis B virus

DMBA

7,12-dimethylbenz[α]anthracene

EBV

Epstein-Barr virus

GSHV

ground squirrel hepatitis virus

HBV

hepatitis B virus

HCC

hepatocellular carcinoma

HHPA

12-O-hexadecanoyl-16-hydroxyphorbol-13-acetate

HPV

human papillomavirus

HTLV

human T-cell leukemia virus

3-MC

3-methylcholanthrene

MuLV

murine leukemia virus

NPC

nasopharyngeal carcinoma

SFV

Shope fibromavirus

SPV

Shope papillomavirus,virus

TPA

12-O-tetradecanoylphorbol-13-acetateV

V

vaccinia virus

WHV

woodchuck hepatitis virus

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Copyright information

© Birkhäuser Boston 1995

Authors and Affiliations

  • Yin-tak Woo
    • 1
  1. 1.Tulane University School of MedicineNew OrleansUSA

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