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Synergism in Carcinogenesis: Mathematical Approaches to its Evaluation

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Chemical Induction of Cancer

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Abstract

Determination of the statistical validity of synergism between two carcinogens is conceptually complex. If the dose-response curves of two carcinogens are linear, then the two carcinogens would be in synergism if the tumor yield, when they are administered together, exceeded that obtained by the summation of the tumor yields from the separate testing of the two carcinogens at their respective single doses. For synergism to be established, the difference must be statistically significant.

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References

  1. Reif, A. E.: J. Natl. Cancer Inst. 73, 25 (1984).

    PubMed  CAS  Google Scholar 

  2. United Nations Scientific Committee on the Effects of Atomic Radiations: “Ionizing Radiation: Sources and Biological Effects”. United Nations, New York, 1982, p. 727.

    Google Scholar 

  3. Brown, C. C.: J. Natl. Cancer Inst. 74, 730 (1985).

    Google Scholar 

  4. Loewe, S: Arzneim. Forsch. 3, 285 (1953).

    CAS  Google Scholar 

  5. Valeriote, F., and Lin, H.: Cancer Chem. Rep. 59, 895 (1975).

    CAS  Google Scholar 

  6. Steel, G. C., and Peckham, M. J.: Int. J. Radiat. Oncol. Biol. Phys. 5, 85 (1979).

    PubMed  CAS  Google Scholar 

  7. Lundin, F. E., Lloyd, J. W., Smith, E. M., Archer, V. E., and Holaday, D.A.: Health Phys. 16, 571 (1969).

    Article  PubMed  Google Scholar 

  8. Band, P., Feldstein, M., Saccomanno, G., Watson, L., and King, G.: Cancer 45, 1273 (1980).

    Article  PubMed  CAS  Google Scholar 

  9. Hammond, E. C., Selikoff, I. J., and Seidman, H.: Ann. N. Y. Acad. Sci 330, 473 (1979).

    Article  PubMed  CAS  Google Scholar 

  10. Meurman, L. O., Kiviluoto, R., and Hakama, M.: Ann. N.Y. Acad. Sci. 330, 491 (1979).

    Article  PubMed  CAS  Google Scholar 

  11. Rothman, K. J., and Keller, A.: J. Chronic. Dis. 25, 711 (1972).

    Article  PubMed  CAS  Google Scholar 

  12. Kolonel, L. N.: Cancer 37, 1782 (1976).

    Article  PubMed  CAS  Google Scholar 

  13. American Cancer Society: “Cancer Facts and Figures 1983”. American Cancer Society, New York, 1982, p. 14.

    Google Scholar 

  14. Reif, A. E.: Natl. Cancer Inst. Monogr. 52, 123 (1979).

    Google Scholar 

  15. Sharp, J. G., and Crouse, D. A.: Radiation Res. 117, 304 (1989)

    Article  PubMed  CAS  Google Scholar 

  16. Reif, A. E.: Oncology 38, 76 (1981).

    Article  PubMed  CAS  Google Scholar 

  17. Reif, A. E.: Cancer 57, 2408 (1986).

    Article  PubMed  CAS  Google Scholar 

  18. Reif, A. E.: J. Natl Cancer Inst. 83, 64 (1991).

    PubMed  CAS  Google Scholar 

  19. Sellers, T. A., Bailey-Wilson, J. E., Elston, R. C., Wilson, A. F., Elston, G. Z., Ooi, W. L., and Rothschild, H.: J. Natl. Cancer Inst. 82, 1272 (1990).

    Article  PubMed  CAS  Google Scholar 

  20. Sellers, T. A., Bailey-Wilson, J. E., Elston, R. C., and Rothschild, H.: J. Natl. Cancer Inst. 83, 65 (1991).

    Article  Google Scholar 

  21. Corallini, A., Pagnani, M., Viadana, P., Camellin, P., Caputo, A., Reschiglian, P., Rossi, S., Altavilla, G., and Barbanti-Brodano, G.: Cancer Res. 47, 6671 (1987)

    PubMed  CAS  Google Scholar 

  22. Bois, F. Y., and Vasseur, P.: J. Natl. Cancer Inst. 74, 729 (1985).

    Google Scholar 

  23. Reif, A. E., and Colton, T.: Carcinogenesis 5, 837 (1984).

    Article  PubMed  CAS  Google Scholar 

  24. Knudson, A. G., Jr.: New Engl J. Med. 301, 606 (1979).

    Article  PubMed  Google Scholar 

  25. Fraumeni, J. F., Jr. (ed.): “Persons at High Risk of Cancer”. Academic Press, New York, 1975.

    Google Scholar 

  26. U.S. Department of Health and Human Services: “The Health Consequences of Smoking. Cancer. A Report of the Surgeon General.” Office on Smoking and Health, Rockville, Maryland, 1982.

    Google Scholar 

  27. McCoy, G. D., Hecht, S. S., and Wynder, E. L.: Prev. Med. 9, 622 (1980).

    Article  PubMed  CAS  Google Scholar 

  28. Potter, V. R.: Yale J. Biol. Med. 53, 367 (1980).

    PubMed  CAS  Google Scholar 

  29. Wynder, E. L., and Hoffman, D.: New Engl. J. Med. 300, 894 (1979).

    Article  PubMed  CAS  Google Scholar 

  30. Van Duuren, B. L., Sivak, A., Katz, C., and Melchionne, S.: J. Natl. Cancer Inst. 47, 235 (1971).

    PubMed  Google Scholar 

  31. Radford, E. P.: Radon Daughters in the Induction of Lung Cancer in Underground Miners. In “Banbury Report 9. Quantification of Occupational Cancer”. (R. Peto and M. Schneiderman, eds.). Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1981, p. 151.

    Google Scholar 

  32. Axelson, O., and Sundell, L.: Scand. J. Environ. Health 4, 46 (1978).

    CAS  Google Scholar 

  33. Reif, A. E.: Nature 190, 415, (1961).

    Article  PubMed  CAS  Google Scholar 

  34. Hewlett, P. S., and Plackett, R. L.: Biometrics 15, 591 (1959).

    Article  CAS  Google Scholar 

  35. Wahrendorf, J., and Brown, C. C.: Biometrics 36, 653 (1980).

    Article  PubMed  CAS  Google Scholar 

  36. Farber, E.: New Engl J. Med. 305, 1379 (1981).

    Article  PubMed  CAS  Google Scholar 

  37. Pitot, H. C.: Cancer 49, 1206 (1982).

    Article  PubMed  CAS  Google Scholar 

  38. Heldin, C. H., Betsholtz, C., Claesson-Welch, L., and Westermark, B.: Biochim. Biophys. Acta 907, 219 (1987).

    PubMed  CAS  Google Scholar 

  39. Boyd, J. A., and Barrett, J. C.: Mol. Carcinogenesis 3, 325 (1990).

    Article  CAS  Google Scholar 

  40. Bouck, N. P., and Benton, B. K.: Chem. Res. Toxicol. 2, 1 (1989).

    Article  PubMed  CAS  Google Scholar 

  41. Land, H., Parada, L. F., and Weinberg, R. A.: Nature 304, 596 (1983).

    Article  PubMed  CAS  Google Scholar 

  42. Whittemore, A. S.: Adv. Cancer Res. 27, 55 (1978).

    Article  PubMed  CAS  Google Scholar 

  43. Holden, C.: Science 222 602 (1983).

    Article  Google Scholar 

  44. Bowden, G. T., and Krieg, P.: Environ. Health Perspect. 93, 51 (1991).

    Article  PubMed  CAS  Google Scholar 

  45. Cothern, C. R.: Environ. Carcino. Rev. C7, 75 (1989).

    Article  CAS  Google Scholar 

  46. Woo, Y. T., Lai, D. Y., Arcos, J. C., and Argus, M. F.: “Chemical Induction of Cancer, Vol. IIIC, Natural, Metal, Fiber, and Macromolecular Carcinogens”. Academic Press, San Diego, 1988.

    Google Scholar 

  47. Caporaso, N. E., Tucker, M. A., Hoover, R. N., Hayes, R. B., Pickle, L. W., Issaq, H. J., Muschik, G. M., Green-Gallo, L., Buivys, D., Aisner, S., Resau, J. H., Trump, B. F., Tollerud, D., Weston, A., and Harris, C. C.: J. Natl. Cancer Inst. 82, 1264 (1990).

    Article  PubMed  CAS  Google Scholar 

  48. Colton, T.: “Statistics in Medicine”. Little, Brown, Boston, 1974, p. 163.

    Google Scholar 

  49. Hogan, M. D., Kupper, L. L., Most, B. M., and Haseman, J. K.: Am. J. Epidemiol. 108, 60 (1978).

    PubMed  CAS  Google Scholar 

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Authors
  1. Arnold E. Reif
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Washington, D.C., 20460, USA

    Joseph C. Arcos , Mary F. Argus  & Yin-tak Woo ,  & 

  2. Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Joseph C. Arcos  & Mary F. Argus  & 

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© 1995 Birkhäuser Boston

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Reif, A.E. (1995). Synergism in Carcinogenesis: Mathematical Approaches to its Evaluation. In: Arcos, J.C., Argus, M.F., Woo, Yt. (eds) Chemical Induction of Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4076-1_3

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  • DOI: https://doi.org/10.1007/978-1-4612-4076-1_3

  • Publisher Name: Birkhäuser Boston

  • Print ISBN: 978-1-4612-8640-0

  • Online ISBN: 978-1-4612-4076-1

  • eBook Packages: Springer Book Archive

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