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Hormonal Carcinogenesis

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Chemical Induction of Cancer

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Abstract

The dawn of hormonal carcinogenesis began with Beatson’s (1) demonstration in 1898 that ovariectomy ameliorates the clinical course of breast cancer in women, carrying the implication that this cancer is due to/maintained by the continuous stimulus of ovarian hormone. This observation was confirmed in 1919 by Loeb in a rodent model (2). However, it was not until nearly 35 years later after Beatson’s observation that Lacassagne (3) reported the induction of mammary tumors in mice by prolonged treatment with large doses of estrogen. This study launched the era of hormonal carcinogenesis. The initial observation was confirmed and extended by Gardner et al. (4–6), Nelson (7, 8), Shimkin and Grady (9), and many subsequent investigators.

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Authors and Affiliations

  1. U.S. Environmental Protection Agency, Washington, D.C., 20460, USA

    Joseph C. Arcos, Mary F. Argus & Yin-tak Woo

  2. Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Joseph C. Arcos & Mary F. Argus

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    Joseph C. Arcos , Mary F. Argus  & Yin-tak Woo ,  & 

  2. Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Joseph C. Arcos  & Mary F. Argus  & 

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Arcos, J.C., Argus, M.F., Woo, Yt. (1995). Hormonal Carcinogenesis. In: Arcos, J.C., Argus, M.F., Woo, Yt. (eds) Chemical Induction of Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4076-1_23

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