Abstract
The nutritional status of the host may significantly affect chemical carcinogenesis through modification of its microsomal mixed-function oxidase (MFO) system in the target tissue(s). The MFO system, a multifunction monooxygenase enzyme system—consisting of cytochrome P-450 (as the terminal oxidase) and cytochrome P-450 reductase—is the key enzyme system involved in the activation and/or detoxification of most, if not all, chemical carcinogens. The overall effect of nutritional modification of chemical carcinogenesis via MFO is dependent on: (i) the type of nutritional factor, (ii) the metabolic activation/detoxification profile of the chemical carcinogen, (iii) the specific enzymic form of cytochrome P-450 affected, and (iv) the specific target tissue involved.
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References
Campbell, T. C., and Hayes, J. R.: Pharmacol. Rev. 26, 171 (1974).
Hayes, J. R., and Campbell, T. C.: Nutrition as a Modifier of Chemical Carcinogenesis. In “Modifiers of Chemical Carcinogenesis” (T. J. Slaga, ed.), Carcinogenesis-A Comprehensive Survey, Vol. 5. Raven Press, New York, 1980, p. 207.
Norred, W. P., and Wade, A. E.: Biochem. Pharmacol. 21, 2887 (1972).
Venkatesan, N., Arcos, J. C., and Argus, M. F.: Cancer Res. 30, 2563 (1970).
Jervell, K. F., Christoffersen, T., and Morland, J.: Arch. Biochem. 111, 15 (1965).
Alvares, A. P., Kappas, A., Anderson, K. E., Pantuck, E. J., and Conney, A. H.: Nutritional Factors Regulating Drug Biotransformation in Man. In “Drug Action Modification — Comparative Pharmacology” (G. Olive, ed.), Vol. 8 Adv. Pharmacol. Therap. (Proc. 7th Int. Congr. Pharmacol., Paris, 1978). Pergamon, Oxford, 1979, p. 43.
Becking, G. C.: Can. J. Physiol. Pharmacol. 51, 6 (1973).
Wattenberg, L. W.: J. Natl. Cancer Inst. 60, 11 (1978).
Woo, Y.-T., Lai, D. Y., Arcos, J. C., and Argus, M. F.: “Chemical Induction of Cancer,” Vol. IIIC. Academic Press, Orlando, Florida, 1988.
Azuine, M. A., and Bhide, S. V.: Nutr. Cancer 17, 77 (1992).
Kawata, S., Tamura, S., Matsuda, Y., Ito, N., and Matsuzawa, Y.: Carcinogenesis 13, 2121 (1992).
Guengerich, F. P.: Cancer Res. 48, 2946 (1988).
Gonzalez, F. J.: Pharmacol. Ther. 45, 1 (1990).
Nebert, D. E., Nelson, D. R., Coon, M. J., Estabrook, R. W., Feyercisen, R., Fuji-Kuriyama, Y., Gonzalez, F. J., Guengerich, F. J., Gonsalus, I. C., Johnson, E. F., Lopez, J. C., Sato, R., Waterman, M. R., and Waxman, D. J.: DNA Cell Biol. 10, 1 (1991).
Swann, P. F., and McLean, A. E. M.: Biochem. J. 124, 283 (1972).
Mile, J. S., and Wolf, C. R.: Carcinogenesis 12, 2195 (1991).
Vang, O., Jensen, M. B., and Autrup, H.: Carcinogenesis 11, 259 (1990).
Jost, J. P., Khairallah, E. A., and Pitot, H. C.: Biol. Chem. 243, 3057 (1968).
Lang, M.: Gen. Pharmacol. 7, 416 (1976).
Lang, M.: Biochim. Biophys. Acta 455, 947 (1976).
Stier, A.: Biochem. Pharmacol. 25, 109 (1976).
Duppel, W., and Ullrich, V.: Biochim. Biophys. Acta 426, 399 (1976).
Murphy, M. G.: J. Nutr. Biochem. 1, 68 (1990).
Levy, H. A., and DiPalma, J. R.: J. Pharmacol. Expt. Therap. 109, 377 (1953).
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Arcos, J.C., Argus, M.F., Woo, Yt. (1995). Indirect Modification of Chemical Carcinogenesis by Nutritional Factors Through Regulation of the Mixed-Function Oxidase System. In: Arcos, J.C., Argus, M.F., Woo, Yt. (eds) Chemical Induction of Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4076-1_18
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DOI: https://doi.org/10.1007/978-1-4612-4076-1_18
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