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Modulation by Vitamins

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Chemical Induction of Cancer

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Abstract

Vitamins have long been known to be essential for the normal physiological functions of humans and animals (rev. in 1). Evidence has been accruing for some years that vitamins also have an important influence on carcinogenesis. Dietary deficiency in certain vitamins and quasi-vitamins2 was found to be associated with increased susceptibility to, whereas dietary supplementation with a variety of vitamins showed protective effect against, carcinogenesis. When given in large amounts, however, some vitamins may enhance the effects of chemical carcinogens. This section presents a brief overview of the physiological and biochemical roles of vitamins with emphasis on their modulation of chemical carcinogenesis in experimental animals.

The term “quasi-vitamins” has been used to denote compounds which appear to satisfy the criteria of vitamin status, but for only a few species or under only certain conditions. The list of quasi-vitamins includes such compounds as choline, carnitine, and myo-inositol which are required for optimal growth of certain poultry, insects, and fishes, respectively. A number of other compounds (pyrroloquinoline quinone, ubiquinones, orotic acid, bioflavonoids, p-aminobenzoic acid, lipoic acid) have also yielded some evidence for nutritional essentiality and are loosely considered as quasi-vitamins (see ref. 1).

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Authors
  1. Edgar Petru
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  2. Yin-tak Woo
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  3. Martin R. Berger
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Editors and Affiliations

  1. U.S. Environmental Protection Agency, Washington, D.C., 20460, USA

    Joseph C. Arcos , Mary F. Argus  & Yin-tak Woo ,  & 

  2. Tulane University School of Medicine, New Orleans, LA, 70112, USA

    Joseph C. Arcos  & Mary F. Argus  & 

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© 1995 Birkhäuser Boston

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Petru, E., Woo, Yt., Berger, M.R. (1995). Modulation by Vitamins. In: Arcos, J.C., Argus, M.F., Woo, Yt. (eds) Chemical Induction of Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4076-1_15

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  • DOI: https://doi.org/10.1007/978-1-4612-4076-1_15

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