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Immunotoxicology of Chemical Carcinogens

  • Chapter
Chemical Induction of Cancer

Abstract

The immune system constitutes the first and primary defense against the environment. It provides defense against foreign substances and organisms such as bacteria and viruses. It is also a surveillance system for protection against the development of malignant disease. When the immune system is severely compromised there are lifethreatening consequences. The devastating consequences of the acquired immune deficiency syndrome (AIDS) exemplifies the importance of a healthy immune system.

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References

  1. Roitt, I., Brostoff, J., and Male, D.: “Immunology”. Gower, London, England, 1989, pp. 2.13–2.14.

    Google Scholar 

  2. Nomenclature Committee: J. Immunol 143, 758 (1989).

    Google Scholar 

  3. Jackson, A., and Warner, H.: Preparation Stainings and Analysis by Flow Cytometry of Peripheral Blood Leukocytes. In “Manual of Clinical Laboratory Immunology” (N. Rose, H. Friedman, and J. Fahey, eds.). Am. Soc. Microbiol., Washington, D.C., 1986, p. 226.

    Google Scholar 

  4. Reinherz, E. L., and Schlossman, S.: Cell 19, 821 (1980).

    Article  PubMed  CAS  Google Scholar 

  5. Zinkernagel, R., and Doherty, P.: Adv. Immunol. 27, 51 (1979).

    Article  PubMed  CAS  Google Scholar 

  6. Dorf, M., and Benacerraf, B.: Annu. Rev. Immunol. 2, 127 (1984).

    Article  PubMed  CAS  Google Scholar 

  7. Paul, W. E.: The Immune System: An Introduction. In “Fundamental Immunology” (W. E. Paul, ed.), 2nd ed. Raven Press, New York, 1989, p. 3.

    Google Scholar 

  8. Sprent, J., Schaefer, M., Lo, D., and Korngold, R.: J. Exp. Med. 163, 998 (1986).

    Article  PubMed  CAS  Google Scholar 

  9. Cobbold, S., and Waldman, H.: Transplantation 41, 634 (1986).

    Article  PubMed  CAS  Google Scholar 

  10. Rosenberg, A. S., Mizuochi, T., Sharrow, S. O., and Singer, A.: J. Exp. Med. 165, 1296 (1987).

    Article  PubMed  CAS  Google Scholar 

  11. Clement, L. T.: J. Clin. Immunol. 12, 1 (1992).

    Article  PubMed  CAS  Google Scholar 

  12. Kincade, P. W.: Adv. Immunol 31, 177 (1981).

    Article  PubMed  CAS  Google Scholar 

  13. Kuritani, T., and Cooper, M.: J. Exp. Med. 155, 389 (1982).

    Google Scholar 

  14. Ritz, J., Schmidt, R. E., Michon, J., Hercend, T., and Schlossman, S. F.: Adv. Immunol. 42, 181 (1988).

    Article  PubMed  CAS  Google Scholar 

  15. Phillips, J. H., and Lanier, L. L.: Exp. Med. 164, 814 (1986).

    Article  CAS  Google Scholar 

  16. Berke, G.: Functions and Mechanisms of Lysis Induced by Cytotoxic T Lymphocytes and Natural Killer Cells. In “Fundamental Immunology” (W. E. Paul, ed.), 2nd ed. Raven Press, New York, 1989, p. 735.

    Google Scholar 

  17. van Furth, R.: Cells of the Mononuclear Phagocyte System. Nomenclature in Terms of Sites and Conditions. In “Mononuclear Phagocytes, Functional Aspects” (R. van Furth, ed.). Martinus-Nijhoff, The Hague, Netherlands, 1980, p. 1.

    Google Scholar 

  18. Unanue, E. R.: Macrophages, Antigen-Presenting Cells, and the Phenomena of Antigen Handling and Presentation. In “Fundamental Immunology” (W. E. Paul, ed.), 2nd ed. Raven Press, New York, 1989, p. 95.

    Google Scholar 

  19. Meltzer, M. S., and Nacy, C. A.: Delayed-Type Hypersensitivity and the Induction of Activated Cytotoxic Macrophages. In “Fundamental Immunology” (W. E. Paul, ed.), 2nd ed. Raven Press, New York, 1986, p. 765.

    Google Scholar 

  20. Allison, J. P., McIntyre, B. W., and Bloch, D.: J. Immunol. 129, 2293 (1982).

    PubMed  CAS  Google Scholar 

  21. Meuer, S. C., Fitzgerald, K. A., Hussey, R. E., Hodgson, J. C., Schlossman, S. F., and Reinherz, E. L.: J. Exp. Med. 157, 705 (1983).

    Article  PubMed  CAS  Google Scholar 

  22. Haskins, K., Kubo, R., White, J., Pigeon, M., Kappler, J., and Marrack, P.: J. Exp. Med. 157, 1149 (1983).

    Article  PubMed  CAS  Google Scholar 

  23. Samelson, L. E., Harford, H. B., and Klausner, R. D.: Cell 43, 223 (1985).

    Article  PubMed  CAS  Google Scholar 

  24. Chien, Y., Becker, D. M., Lindsten, T., Okamura, M., Cohen, D. I., and Davis, M. M.: Nature 312, 31 (1984).

    Article  PubMed  CAS  Google Scholar 

  25. Saito, H., Kranz, D., Takagaki, Y., Hayday, A., Eisen, H., and Tonegawa, S.: Nature 312, 36 (1984).

    Article  PubMed  CAS  Google Scholar 

  26. Hedrick, S. M., Cohen, D. I., Nielsen, E. A., and Davis, M. M.: Nature 308, 149 (1984).

    Article  PubMed  CAS  Google Scholar 

  27. Yanagi, Y., Yoshikai, Y., Leggett, K., Clark, S. P., Aleksander, I., and Mak, T. W.: Nature 308, 145 (1984).

    Article  PubMed  CAS  Google Scholar 

  28. Hedrick, S. M., Nielsen, E. A., Kavaler, J., Cohen, D. I., and Davis, M. M.: Nature 308, 153 (1984).

    Article  PubMed  CAS  Google Scholar 

  29. Meuer, S. C., Schlossman, S. F., and Reinherz, E.: Proc. Natl. Acad. Sci. U.S.A. 79, 4395 (1982).

    Article  PubMed  CAS  Google Scholar 

  30. Spits, H., Borst, J., Terhorst, C., and de Vries, J. E.: J. Immunol. 129, 1563 (1982).

    PubMed  CAS  Google Scholar 

  31. Krensky, A. M., Reiss, C. S., Nier, J. W., Strominger, J. L., and Burakoff, S. J.: Proc. Natl. Acad. Sci. U.S.A. 79, 2365 (1982).

    Article  PubMed  CAS  Google Scholar 

  32. Babbit, B. P., Allen, P. M., Matsueda, G., Haber, E., and Unanue, E. R.: Nature 317, 359 (1985).

    Article  Google Scholar 

  33. Buus, A., Sette, A., Colon, S. M., Janis, D. M., and Grey, H. M.: Cell 47, 1071 (1986).

    Article  PubMed  CAS  Google Scholar 

  34. Germain, R. N.: Nature 322, 687 (1986).

    Article  PubMed  CAS  Google Scholar 

  35. Morrison, L. A., Lukacher, A. E., Braciale, V. L., Fan, D. P., and Braciale, T. J.: J. Exp. Med. 163, 903 (1986).

    Article  PubMed  CAS  Google Scholar 

  36. Green, A. R.: Lancet 1, 705 (1989).

    Article  PubMed  CAS  Google Scholar 

  37. Kurt-Jones, E. A., Biller, D. I., Mizel, S. B., and Unanue, E. R.: Proc. Natl. Acad. Sci. U.S.A. 82,1204 (1985).

    Article  PubMed  CAS  Google Scholar 

  38. O’Garra, A. O.: Lancet 1, 1003 (1989).

    Article  PubMed  Google Scholar 

  39. Miyasaki, N., Sato, K., Goto, M., Sasano, M., Natsuyama, M., Inoue, K., and Nishioka, K.: Arthritis Rheumatol. 31, 480 (1988).

    Article  Google Scholar 

  40. Buchan, G., Barrett, K., Turner, M., Chantry, D., Maini, R. N., and Feldmann, M.: Clin. Exp. Immunol. 73, 449 (1988).

    PubMed  CAS  Google Scholar 

  41. Maury, C. P. J., Salo, E., and Pelkonen, P.: New Engl. J. Med. 319, 1670 (1988).

    Article  PubMed  CAS  Google Scholar 

  42. Seckinger, P., and Dayer, J. M.: Ann. Inst. Pasteur Immunol. 138, 486 (1987).

    Article  PubMed  CAS  Google Scholar 

  43. Morgan, D. A., Ruscetti, F. W., and Gallo, R.: Science 193, 1007 (1976).

    Article  PubMed  CAS  Google Scholar 

  44. Gillis, S., Ferm, M. M., Ou, W., and Smith, K. A.: J. Immunol. 120, 2027 (1978).

    PubMed  CAS  Google Scholar 

  45. Malkovsky, M., Sondel, P. M., Strober, W., and Dalgleish, A. G.: Clin. Exp. Immunol. 74, 151 (1988).

    PubMed  CAS  Google Scholar 

  46. Dinarrello, C. A., and Mier, J. W.: New Engl. J. Med. 317, 940 (1987).

    Article  Google Scholar 

  47. Warrington, R. J.: J. Rheumatol. 15, 616 (1988).

    PubMed  CAS  Google Scholar 

  48. Campen, D. H., Horwitz, D. A., Quismorio, F. P., Jr., Ehresmann, G. R., and Martin, W. J.: Arthritis Rheumatol. 31, 1358 (1988).

    Article  CAS  Google Scholar 

  49. Josimovic-Alasevic, O., Feldmeier, H. J., Zwingenberger, K., Harms, G., Hahn, H., Shrisuphanunt, M., and Diamantstein, I.: Clin. Exp. Immunol. 72, 249 (1988).

    PubMed  CAS  Google Scholar 

  50. Sethi, K. K., and Naher, H.: Immunol. Lett. 13, 179 (1986).

    Article  PubMed  CAS  Google Scholar 

  51. Manoussakis, M. N., Papadopoulos, G. K., Drosos, A. A., and Moutsopoulos, H. M.: Clin. Immunol. Immunopathol. 50, 321 (1989).

    Article  PubMed  CAS  Google Scholar 

  52. Schrader, J. W.: Annu. Rev. Immunol. 4, 205 (1986).

    Article  PubMed  CAS  Google Scholar 

  53. Oettgen, H. F., and Old, L. J.: The History of Cancer Immunotherapy. In: “Biologic Therapy of Cancer” (V. T. De Vita, Jr., S. Hellman, and S. A. Rosenberg, eds.). Lippincott, Philadelphia, 1991, p. 87.

    Google Scholar 

  54. Vercelli, D., Jabara, H. H., Arai, K. -I., and Geha, R. S.: J. Exp. Med. 169, 1295 (1989).

    Article  PubMed  CAS  Google Scholar 

  55. Harriman, G. R., and Strober, W.: J. Immunol. 139, 3553 (1987).

    PubMed  CAS  Google Scholar 

  56. Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., Sakiyama, F., and Kishimoto, T.: Proc. Natl. Acad. Sci. U.S.A. 84,228 (1987).

    Article  PubMed  CAS  Google Scholar 

  57. Freeman, G. J., Freedman, A. S., Rabinowe, S. N., Segil, J. M., Horowitz, J., Rosen, K., Whitman, J. F., and Nadler, L. M.: J. Clin. Invest. 83, 1512 (1989).

    Article  PubMed  CAS  Google Scholar 

  58. Sutton, M. G. S. J., Mercier, L., Giulliani, E. R., and Lie, J. T.: Mayo Clin. Proc. 55, 371 (1980).

    Google Scholar 

  59. Wasge, A., Kaufmann, C., Espevik, T., and Husby, G.: Clin. Immunol. Immunopathol. 50, 394 (1989).

    Article  Google Scholar 

  60. Morrissey, P. J., Goodwin, R. G., Nordan, R. P., Anderson, D., Grabstein, K. H., Cosman, D., Sims, J., Lupton, S., Acres, B., Reed, S. G., Mochizuki, D., Eisenman, J., Conlon, P. J., and Namen, A. E.: J. Exp. Med. 169, 707 (1989).

    Article  PubMed  CAS  Google Scholar 

  61. Larsen, C. G., Anderson, A. O., Appella, E., Oppenheim, J. J., and Matsushima, K.: Science 243, 1464 (1989).

    Article  PubMed  CAS  Google Scholar 

  62. Isaacs, A., and Lindeman, J.: Proc. Roy. Soc. Lond. (Biol.) 259, 67 (1957).

    Google Scholar 

  63. Balkwill, F. R.: Lancet 1, 1060 (1989).

    Article  PubMed  CAS  Google Scholar 

  64. Panitch, H. S., Hirsch, R. L., Hally, A. S., and Johnson, K. P.: Lancet 1, 893 (1987).

    Article  PubMed  CAS  Google Scholar 

  65. Westwick, J., Li, S. W., and Camp, R. D.: Immunol. Today 10, 146, (1989).

    Article  PubMed  CAS  Google Scholar 

  66. Jerne, N. K.: Immunol. Rev. 79, 193 (1983).

    Google Scholar 

  67. Hodes, R. J.: T-Cell-Mediated Regulation: Help and Suppression. In “Fundamental Immunology” (W. E. Paul, ed.), 2nd ed. Raven Press, New York. 1989, p. 587.

    Google Scholar 

  68. Svejgaard, A., Plotz, P., and Ryder, L.: Immunol. Rev. 70, 193 (1983).

    Article  PubMed  CAS  Google Scholar 

  69. Burnet, F. M.: Progr. Exp. Tumor Res. 13, 1 (1970).

    PubMed  CAS  Google Scholar 

  70. Penn, I.: “Principles of Tumor Immunity: Immuno-competence and Cancer.” In “Biologic Therapy of Cancer” (V. T. De Vita, Jr., S. Hellman, and S. A. Rosenberg, eds.). Lippincott, Philadelphia, 1991, p. 53.

    Google Scholar 

  71. Ettinghausen, S. E., and Rosenberg, S. A.: Springer Semin. Immunopathol. 9, 51 (1986).

    Article  PubMed  CAS  Google Scholar 

  72. Rosenberg, S. A., Spiess, P., and Lafrelniere, R.: Science 233, 131 (1986).

    Article  Google Scholar 

  73. Herberman, R. B.: “NK Cells and Other Natural Effector Cells.” Academic Press, New York, 1982.

    Google Scholar 

  74. Volkman, A.: “Mononuclear Phagocyte Function”. Dekker, New York, 1984.

    Google Scholar 

  75. Topalain, S. L., Soloman, D., and Rosenberg, S. A.: Immunology 142, 3714 (1989).

    Google Scholar 

  76. Rosenberg, S. A., Packard, B. S., Aebersold, P. M., Solomon, D., Topalian, S. L., Toy, S. T., Simon, P., Lotze, M. T., Yang, J. C., Seipp, C. A., Simpson, C., Carter, C., Bock, S., Schwartzentruber, D., Wei, J. P., and White, D. E.: N. Engl. J. Med. 319, 1676 (1988).

    Article  PubMed  CAS  Google Scholar 

  77. Topalian, S. L., and Rosenberg, S. A.: Adaptive Cellular Therapy: Basic Principles. In “Biologic Therapy of Cancer” (V. T. De Vita, Jr., S. Hellman, and S. A. Rosenberg, eds.). Lippincott, Philadelphia, 1991, p. 178.

    Google Scholar 

  78. Office of Technology Assessment: “Identifying and Controlling Immunotoxic Substances” (Background paper). OTA, United States Congress, Washington, D.C., 1991.

    Google Scholar 

  79. Salvaggio, J. E., and Sullivan, K. A.: Environmental Chemicals and the Immune System. In Environmental and Occupational Medicine ” (W. N. Rom, ed.), 2nd ed. Little, Brown, Boston, 1992, p. 69.

    Google Scholar 

  80. Zetterstrom, O., Nordvall, S. L., Bjorksten, B., Ahlstedt, S., and Stelander, M.: J. Allergy Clin. Immunol. 75, 594 (1985).

    Article  PubMed  CAS  Google Scholar 

  81. Kjellman, N.-I. M.: Lancet 1, 993 (1981).

    Article  PubMed  CAS  Google Scholar 

  82. Muranaka, M., Suzuki, S., Koizumi, K., Takafuji, S., Miyamoto, T., Ikemori, R., and Tokiwa, H.: J. Allergy Clin. Immunol. 77, 616 (1986).

    Article  PubMed  CAS  Google Scholar 

  83. World Health Organization: “Cancer-Causes, Occurrence and Control”, IARC Sci. Publ. 100, IARC Lyon France, 1990.

    Google Scholar 

  84. Woo, Y.-t., and Arcos, J. C.: Environmental Chemicals. In “Carcinogens in Industry and the Environment” (J. M. Sontag, ed.). Dekker, New York, 1981, p. 168.

    Google Scholar 

  85. Harvey, R. G.: Am. Scientist 70, 386 (1982).

    PubMed  CAS  Google Scholar 

  86. Zedeck, M. S. J.: Environ. Pathol. Toxicol. 3, 537 (1980).

    CAS  Google Scholar 

  87. Ward, E. C., Murray, M. J., and Dean, J. H.: Immunotoxicity of Nonhalogenated Polycyclic Aromatic Hydrocarbons. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 291.

    Google Scholar 

  88. White, K. L., Jr.: Environ. Carcino. Rev. C4, 163 (1986).

    Article  CAS  Google Scholar 

  89. Medina, D., Stockman, G., and Griswold, D.: Cancer Res. 34, 2663 (1974).

    PubMed  CAS  Google Scholar 

  90. Yamashita, U., and Hamaoka, T.: Gann 73, 773 (1982).

    PubMed  CAS  Google Scholar 

  91. Ladics, G. S., Kawabata, T. T., and White, K. L.: Toxicol. Appl. Pharmacol. 110, 31 (1991).

    Article  PubMed  CAS  Google Scholar 

  92. DiGiovanni, G., and Juchau, M. R.: Metab. Rev. 11, 61 (1980).

    Article  CAS  Google Scholar 

  93. Urso, P., and Gengozian, N.: J. Toxicol. Environ. Health 6, 569 (1980).

    Article  PubMed  CAS  Google Scholar 

  94. Davis, D., and Safe, S.: Toxicology 63, 97 (1990).

    Article  PubMed  CAS  Google Scholar 

  95. Bozelka, B. E., and Salvaggio, J. E.: Environ. Carcino. Rev. 3, 1 (1985).

    Google Scholar 

  96. Selikoff, I. J., Hammond, E. C., and Seildman, H.: Ann. N. Y. Acad. Sci. 330, 91 (1979).

    Article  PubMed  CAS  Google Scholar 

  97. Miller, K., and Brown, R. C.: The Immune System and Asbestos-Associated Disease. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). New York, Raven Press, 1985, p. 429.

    Google Scholar 

  98. Boorman, G. A., Dean, J. H., Luster, M. I., Adkins, B., Brody, A., and Hong, H. L.: Toxicol. Appl. Pharmacol. 72, 148 (1984).

    Article  PubMed  CAS  Google Scholar 

  99. de Shazo, R. D., Hendrick, D. J., Diem, J. E., Nordberg, J., Baser, Y., Bevier, D., Jones, R. N., Barkman, H. W., Salvaggio, J. E. and Weill, H.: J. Allergy Clin. Immunol. 72, 454 (1983).

    Article  Google Scholar 

  100. Miller, L. G., Sparrow, D., and Ginns, L. C.: Clin. Exp. Immunol. 51, 110 (1983).

    PubMed  CAS  Google Scholar 

  101. Strom, T. B.: Immunosuppression in Tissue and Organ Transplantation. In “Organ Transplantation- Current Clinical and Immunological Concepts” (L. Brent and R. A. Sills, eds.). Bailliere Tindall, London, 1989, p. 39.

    Google Scholar 

  102. Sigal, N. H., and Dumont, F. J.: Annu. Rev. Immunol. 10, 519 (1992).

    Article  PubMed  CAS  Google Scholar 

  103. Mihich, E., and Ehrke, M. J.: Immunomodulation by Anticancer Drugs. In “Biologic Therapy of Cancer” (V. T. De Vita, Jr., S. Hellman, and S. A. Rosenberg, eds.). Lippincott, Philadelphia, 1991, p. 776.

    Google Scholar 

  104. Ehrke, M. J., Mihich, E., Berd, D., and Mastrangelo, M. J.: Semin. Oncol. 16, 230 (1989).

    PubMed  CAS  Google Scholar 

  105. Penn, I.: Neoplastic Consequences of Immunosuppression. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E., Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 79.

    Google Scholar 

  106. Spreafico, F., Allegrucci, M., Merendino, A., and Luini, W.: Chemical Immunodepressive Drugs: Their Action on the Cells of the Immune System and Immune Mediators. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 179.

    Google Scholar 

  107. Exon, J. H., Kerkvliet, N. I., and Talcott, P. A.: Environ. Carcino. Rev. C5, 73 (1987).

    Article  CAS  Google Scholar 

  108. Thomas, P. T., and Faith, R. E.: Adult and Perinatal Immunotoxicity Induced by Halogenated Aromatic Hydrocarbons. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 305.

    Google Scholar 

  109. Silkworth, J. B., and Vecchi, A.: Role of the Ah Receptor in Halogenated Aromatic Hydrocarbon Immunotoxicity. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 263.

    Google Scholar 

  110. Bekesi, J. G., Roboz, J., Fischbein, A., Roboz, J. P., Salomon, S. and Greaves, J.: Immunological, Biochemical, and Clinical Consequences of Exposure to Polybrominated Biphenyls. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 393.

    Google Scholar 

  111. Hoffman, R. E., Stehr-Green, P. A., Webb, K. B., Evans, R. G., Knutsen, A. P., Schramm, W. F., Staake, J. L., Gibson, B. B., and Steinberg, K. K.: JAMA 255, 2031 (1986).

    Article  PubMed  CAS  Google Scholar 

  112. Fingerhut, M. A., Halperin, W. E., Marlow, D. A., Piacetelli, L. A., Honchar, P. A., Sweeney, M. H., Greife, A. L., Dill, P. A., Steenland, K., and Suruda, A. J.: New Engl. J. Med. 324, 212 (1991).

    Article  PubMed  CAS  Google Scholar 

  113. Dean, T. N., Kakkanaiah, V. N., Nagarkatti, M., and Nagarkatti, P. S.: Toxicol. Appl. Pharmacol. 106, 408 (1990).

    Article  PubMed  CAS  Google Scholar 

  114. Lee, T. P., and Chang, K. J.: Health Effects of Polychlorinated Biphenyls. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 415.

    Google Scholar 

  115. Olson, L. J., Erickson, B. J., Hinsdell, R. D., Wyman, J. A., Porter, W. P., Binning, L. K., Bidgood, R. C., and Nordheim, E. V.: Arch. Environ. Contam. Toxicol. 16, 433 (1987).

    Article  PubMed  CAS  Google Scholar 

  116. Luebke, R. W., Rogers, R. R., Riddle, M. M., Rowe, D. G., and Smialowicz, R.: Immunopharmacology. 13, 1 (1987).

    Article  PubMed  CAS  Google Scholar 

  117. Hermanowicz, A., and Kossman, S.: Clin. Immunol. Immunopathol. 33, 13 (1984).

    Article  PubMed  CAS  Google Scholar 

  118. Lawrence, D. A.: Immunotoxicity of Heavy Metals. In “Immunotoxicology and Immunopharmacology” (J. H. Dean, M. I. Luster, A. E. Munson, and H. Amos, eds.). Raven Press, New York, 1985, p. 341.

    Google Scholar 

  119. Borella, P., and Giordina, A.: Environ. Res. 55, 165. (1991).

    Article  PubMed  CAS  Google Scholar 

  120. Bozelka, B. E., Burkholder, P. M., and Chang, L. W.: Environ. Res. 17, 390 (1978).

    Article  PubMed  CAS  Google Scholar 

  121. Bozelka, B. E., and Burkholder, P. E.: Environ. Res. 27, 421 (1982).

    Article  PubMed  CAS  Google Scholar 

  122. Sakaguchi, S., Sakaguchi, T., Nakamura, I., and Kudo, Y.: Pharmacol. Toxicol. 61, 325 (1987).

    Article  PubMed  CAS  Google Scholar 

  123. Williams, W. R., and Williams, W. J.: Arch. Allergy Appl. Immunol. 67, 175 (1982).

    Article  CAS  Google Scholar 

  124. Price, C. D., Jones Williams, W., Pugh, A., and Joynson, D. H.: J. Clin. Pathol. 30, 24 (1977).

    Article  PubMed  CAS  Google Scholar 

  125. Pepys, J.: Clin. Immunol. Allergy 4, 131 (1984).

    Google Scholar 

  126. Joules, H.: Lancet 2, 1348 (1932).

    Google Scholar 

  127. Dolvich, J., Evans, S. L., and Niebore, E.: Br. J. Ind. Med. 41, 51 (1984).

    Google Scholar 

  128. Malo, J. L., and Cartier, A.: J. Allergy Clin. Immunol. 79, 117 (1987).

    Google Scholar 

  129. Salvaggio, J. E.: J. Allergy Clin. Immunol. 85, 689 (1990).

    Article  PubMed  CAS  Google Scholar 

  130. Luster, M. I., Munson, A. E., Thomas, P. T., Holsapple, M. P., Fenters, J. D., White, Jr., K. L., Lauer, L. D., Germolec, D. R., Rosenthal, G. J., and Dean, J. H.: Fundam. Appl. Toxicol. 10, 2 (1988).

    Article  PubMed  CAS  Google Scholar 

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Sullivan, K.A., Salvaggio, J.E. (1995). Immunotoxicology of Chemical Carcinogens. In: Arcos, J.C., Argus, M.F., Woo, Yt. (eds) Chemical Induction of Cancer. Birkhäuser Boston. https://doi.org/10.1007/978-1-4612-4076-1_12

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