Transplantation of the Pancreas or Pancreatic Islet Cells

A Clinical Laboratory Perspective
  • John A. Lott
Part of the Pathology and Laboratory Medicine book series (PLM, volume 2)


Loss of the exocrine and endocrine pancreatic functions leaves the patient with serious digestive and metabolic problems. Causes of exocrine loss include cystic fibrosis, atrophic pancreatitis, chronic pancreatitis, infarction of the pancreas, surgical removal of the gland, atherosclerosis of the pancreas, pancreatic cysts, and other miscellaneous causes. More than about 85% of the acinar cells must be lost before abnormalities appear, indicating that the normal pancreas has tremendous exocrine reserves. Abdominal discomfort and abnormalities in digestion, including steatorrhea, weight loss, constipation or diarrhea, and flatulence, are typical findings.


Major Histocompatibility Complex Human Leukocyte Antigen Human Leukocyte Antigen Class Pancreas Transplantation Artificial Pancreas 
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Copyright information

© Humana Press Inc. 1997

Authors and Affiliations

  • John A. Lott

There are no affiliations available

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