Pharmacology of Recombinant NMDA Receptors

Possible Mechanisms for NMDA Receptor Heterogeneity
  • David R. Lynch
  • Michael J. Gallagher
  • Shelley J. Lenz
  • Norifusa J. Anegawa
  • Elfrida L. Grant
Part of the The Receptors book series (REC)


Glutamate acts postsynaptically at a variety of receptors, including ionotropic and metabotropic types (Choi, 1988; Collingridge and Lester, 1989; Lipton, 1993). The ionotropic receptors are separated by their prototypic agonists into α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors, kainate receptors, and N-methyl-D-aspartate (NMDA) receptors. The first two types are glutamate-gated cation channels that are relatively impermeable to calcium, whereas the NMDA receptor is a glutamate-gated cation channel with a high permeability to calcium.


NMDA Receptor NMDA Receptor Subunit Glycine Site Glutamate Antagonist Heteromeric Receptor 
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© Humana Press Inc. 1997

Authors and Affiliations

  • David R. Lynch
  • Michael J. Gallagher
  • Shelley J. Lenz
  • Norifusa J. Anegawa
  • Elfrida L. Grant

There are no affiliations available

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