Abstract
The identification and purification of the humoral regulator of platelet production has long been a major goal in the field of hematology. The initial isolation of erythropoietin (EPO) and subsequently of granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colony-stimulating factor (GM-CSF), and monocyte colony-stimulating factor (M-CSF) suggested that a similar lineage-specific factor regulated platelet production. The commercial success of the previously identified lineage-specific factors provided further incentive.
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Kuter, D.J., Miyazaki, H., Kato, T. (1997). The Purification of Thrombopoietin from Thrombocytopenic Plasma. In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D. (eds) Thrombopoiesis and Thrombopoietins. Humana Press. https://doi.org/10.1007/978-1-4612-3958-1_9
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DOI: https://doi.org/10.1007/978-1-4612-3958-1_9
Publisher Name: Humana Press
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