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Mpl Expression and Functional Role in Human Megakaryocytopoiesis

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Thrombopoiesis and Thrombopoietins

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Abstract

The c-mpl gene was discovered in 1990 as the cellular homologue of v-mpl, the oncogene of the murine myeloproliferative leukemia virus, MPLV (see Chapter 6) (1). In mice, v-mpl induces a lethal myeloproliferative disease involving multiple hemopoietic progenitors (2–4). In vitro, v-mpl transformed multipotential and lineage-committed progenitors, leading to acquisition of growth-factor independence for both proliferation and terminal maturation (1), These data showed that v-mpl was a potent deregulator of hemopoiesis, but they did not provide any information about the function of the normal c-mpl proto-oncogene.

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Authors
  1. Françoise Wendling
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  2. Najet Debili
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  3. William Vainchenker
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Editor information

Editors and Affiliations

  1. The MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

    David J. Kuter MD, DPhil

  2. Amgen Inc., Thousand Oaks, California, USA

    Pamela Hunt PhD  & William Sheridan MD  & 

  3. Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA

    William Sheridan MD

  4. Department of Medicine, New York University Medical Center, New York, New York, USA

    Dorothea Zucker-Franklin MD

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© 1997 Humana Press Inc.

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Wendling, F., Debili, N., Vainchenker, W. (1997). Mpl Expression and Functional Role in Human Megakaryocytopoiesis. In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D. (eds) Thrombopoiesis and Thrombopoietins. Humana Press. https://doi.org/10.1007/978-1-4612-3958-1_7

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  • DOI: https://doi.org/10.1007/978-1-4612-3958-1_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8440-6

  • Online ISBN: 978-1-4612-3958-1

  • eBook Packages: Springer Book Archive

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