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The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl

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Thrombopoiesis and Thrombopoietins

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Abstract

Retroviruses are widely distributed in avian and mammalian species, and cause various neoplastic diseases in their natural hosts (1). The type-C retroviruses have been divided into two groups: the replication-competent viruses that induce leukemia in susceptible animals with a long latent period, but do not usually transform cells in culture; and the acute replication-defective viruses that cause leukemias or sarcomas in animals within a few days or weeks and transform cells in vitro. The replication defect of acutely transforming retroviruses is due to the loss of structural genes that are essential for replication with the concomitant acquisition of altered cellular sequences, named oncogenes, responsible for cell transformation. As a result of their replication defectiveness, acutely transforming retroviruses require a helper replication-competent virus for propagation.

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Authors
  1. Françoise Wendling
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  2. Sylvie Gisselbrecht
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Editor information

Editors and Affiliations

  1. The MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

    David J. Kuter MD, DPhil

  2. Amgen Inc., Thousand Oaks, California, USA

    Pamela Hunt PhD  & William Sheridan MD  & 

  3. Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA

    William Sheridan MD

  4. Department of Medicine, New York University Medical Center, New York, New York, USA

    Dorothea Zucker-Franklin MD

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© 1997 Humana Press Inc.

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Wendling, F., Gisselbrecht, S. (1997). The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl . In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D. (eds) Thrombopoiesis and Thrombopoietins. Humana Press. https://doi.org/10.1007/978-1-4612-3958-1_6

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  • DOI: https://doi.org/10.1007/978-1-4612-3958-1_6

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8440-6

  • Online ISBN: 978-1-4612-3958-1

  • eBook Packages: Springer Book Archive

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