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Historical Perspective and Overview

  • Chapter
Thrombopoiesis and Thrombopoietins

Abstract

Although the normal peripheral platelet count varies considerably from person to person, it is clear that platelet production is a regulated physiological process. That such a regulatory system exists is evidenced by the constancy of the normal peripheral platelet count in individuals over time, the capacity of the bone marrow to increase platelet production in the setting of accelerated platelet turnover, and the other alterations that characterize platelets and megakaryocytes produced in the clinical context of varying peripheral platelet demand (1).

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Authors
  1. Eric M. Mazur
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Editors and Affiliations

  1. The MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

    David J. Kuter MD, DPhil

  2. Amgen Inc., Thousand Oaks, California, USA

    Pamela Hunt PhD  & William Sheridan MD  & 

  3. Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA

    William Sheridan MD

  4. Department of Medicine, New York University Medical Center, New York, New York, USA

    Dorothea Zucker-Franklin MD

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© 1997 Humana Press Inc.

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Mazur, E.M. (1997). Historical Perspective and Overview. In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D. (eds) Thrombopoiesis and Thrombopoietins. Humana Press. https://doi.org/10.1007/978-1-4612-3958-1_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3958-1_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8440-6

  • Online ISBN: 978-1-4612-3958-1

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