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Platelet Structure and Function

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Thrombopoiesis and Thrombopoietins

Abstract

Since this is a publication primarily devoted to thrombopoietin (TPO), the ligand for Mpl, and its effect on platelet production so soon after the discovery of this hormone, it is likely that many observations recorded in this book will need to be modified in the future. This will not hold true for the present chapter, which is meant as an anchor to those who have recently entered the field or who may have forgotten what is considered to be normal platelet structure and function, whether in health, in disease, or during spontaneously accelerated thrombocytopoiesis. Only the most relevant information will be recorded here, namely, the properties of platelets that may be affected by TPO when platelets are exposed to its recombinant form in vivo or in vitro. The reader is referred to an exceptionally large body of literature accumulated over many years to be apprised of further details (1–4). Since many of the studies on Mpl carried out to date have, of necessity, been conducted in vitro or in animals, pitfalls in the interpretation of the results arising from differences among species will also be pointed out.

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Authors
  1. Dorothea Zucker-Franklin
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Editor information

Editors and Affiliations

  1. The MGH Cancer Center, Massachusetts General Hospital, Boston, Massachusetts, USA

    David J. Kuter MD, DPhil

  2. Amgen Inc., Thousand Oaks, California, USA

    Pamela Hunt PhD  & William Sheridan MD  & 

  3. Division of Hematology-Oncology, Department of Medicine, UCLA School of Medicine, Los Angeles, California, USA

    William Sheridan MD

  4. Department of Medicine, New York University Medical Center, New York, New York, USA

    Dorothea Zucker-Franklin MD

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© 1997 Humana Press Inc.

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Zucker-Franklin, D. (1997). Platelet Structure and Function. In: Kuter, D.J., Hunt, P., Sheridan, W., Zucker-Franklin, D. (eds) Thrombopoiesis and Thrombopoietins. Humana Press. https://doi.org/10.1007/978-1-4612-3958-1_2

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  • DOI: https://doi.org/10.1007/978-1-4612-3958-1_2

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8440-6

  • Online ISBN: 978-1-4612-3958-1

  • eBook Packages: Springer Book Archive

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