Normal Physiology
  • François P. Pralong
  • William F. CrowleyJr.
Part of the Contemporary Endocrinology book series (COE, volume 3)


The gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), are dimeric pituitary glycoprotein hormones controlling gonadal steroidogenesis and gametogenesis. Their biosynthesis and secretion is tightly regulated by counterbalancing positive inputs from the hypothalamus (GnRH) and negative feedback from the gonads (steroid and peptide hormones). The differential secretion of FSH vs LH can also be achieved by local factors produced within the pituitary gland itself (activin, in-hibin, and follistatin). Integration of these different signals by the gonadotrope results in the coordinate secretion of LH and FSH, ultimately promoting sexual maturation and normal reproductive function. Therefore, gonadotropins play a central role in reproductive biology.


Luteinizing Hormone Follicle Stimulate Hormone Luteinizing Hormone Receptor Gonadotropin Secretion Luteinizing Hormone Surge 
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© Humana Press Inc. 1997

Authors and Affiliations

  • François P. Pralong
  • William F. CrowleyJr.

There are no affiliations available

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