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Molecular and Cellular Ontogeny of Distinct Pituitary Cell Types

  • Cheryl A. Pickeet
  • Authur Gutierrez-Hartmann
Part of the Contemporary Endocrinology book series (COE, volume 3)

Abstract

The development of the anterior pituitary gland has been studied extensively over several decades. With its five distinct cell types, the anterior pituitary provides a model system for investigations of the mechanisms involved in cellular commitment and tissue-specific gene expression. In recent years these studies have begun to yield fascinating information that will be valuable to our general understanding of the molecular interactions that take place during differentiation. In this chapter, we will review the current state of knowledge concerning the role of trophic/growth factors and hormones, the nuclear transcription factors, and the genetic elements required for normal development of the five distinct cell types of the anterior pituitary. We will also discuss the molecular basis of abnormal differentiation/development of the human pituitary and the potential role that aberrancy of these mechanisms may play in certain pituitary disorders. This is a broad topic, and we cannot do justice to all the many invaluable studies that have contributed to our understanding of pituitary development; instead we will concentrate on those areas in which our knowledge is most complete.

Keywords

Growth Hormone Pituitary Adenoma Anterior Pituitary Pituitary Cell Dwarf Mouse 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Humana Press Inc. 1997

Authors and Affiliations

  • Cheryl A. Pickeet
  • Authur Gutierrez-Hartmann

There are no affiliations available

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