Abstract
The gynecological tissues of a mature female, because of their reproductive function, contain examples of the most immature as well as mature cell types. Thus, representation of all three germ layers may be found in tumors originating from these tissues. Moreover, new tissue types appear in the course of pregnancy that may also develop aberrantly and give rise to neoplasms. Some of these tumors illustrate mechanisms of tumorigenesis that differ from those operating in other solid tumors and that appear uniquely related to early development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Heim S, Mitelman F: Cancer Cytogenetics, 2nd edition. New York: Wiley-Liss, 1995.
Taylor RR, Teneriello MG, Nash JD, Park RC, Birrer MJ: The molecular genetics of gynecologic malignancies. Oncology 8:63–70, 1994.
Sreekantaiah C, Chaganti RSK: Cytogenetic aberrations in solid tumors. In: Kaplan BJ, Dale KS (eds.), The Cytogenetic Symposia 1994. Burbank, CA: The Association of Cytogenetic Technologies, pp. 1–11, 1994.
Rodriquez E, Sreekantaiah C, Chaganti RSK: Genetic changes in epithelial solid neoplasia. Cancer Res 54:3398–3406, 1994.
Vanni R, Dal Cin P, Marras S, Moerman P, Andria M, Valdes E, Deprest J, Van Den Berghe H: Endometrial polyp: another benign tumor characterized by 12q13-q15 changes. Cancer Genet Cytogenet 68:32–33, 1993.
Heim S, Nibert M, Vanni R, Floderus U-M, Mandahl N, Liedgren S, Lecca U, Mitelman F: A specific translocation, t(12; 14)(q 14–15;q23–24), characterizes a subgroup of uterine leiomyomas. Cancer Genet Cytogenet 32:13–17, 1988.
Hu J, Surti U: Subgroups of uterine leiomyomas based on cytogenetic analysis. Hum Pathol 22:1009–1016, 1991.
Turc Carel C, Dal Cin P, Rao U, Karakousis C, Sandberg AA: Cytogenetic studies of adipose tissue tumors. I. A benign lipoma with reciprocal translocation t(3;12)(q28;ql4). Cancer Genet Cytogenet 23:283–289, 1986.
Zang ZK: Cytological and cytogenetical study on human meningioma. Cancer Genet Cytogenet 6:249–274, 1982.
Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowicz S, Morton CC, Chada K: Disruption of the architectural factor HMGI-C: DNA binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82:57–65, 1995.
Schoenberg Fejzo M, Ashar H, Tkachenko A, Fletcher JA, Weremowicz S, Yoong S-J, Krauter KS, Kucherlapati R, Chada K, Morton CC: HMGI-C: an architectural factor at 12ql4–15 involved in frequent chromosomal rearrangement in benign tumors. Am J Hum Genet 57:A4, 1995.
Ishwad CS, Ferrell RE, Davare J, Meloni A, Sandberg AA, Surti U: Molecular and cytogenetic analysis of chromosome 7 in uterine leiomyomas. Genes Chromosom Cancer 14:51–55, 1995.
Bardi G, Johansson B, Pandis N, Heim S, Mandahl N, Bar-Jensen E, Frederiksen H, Sandberg AA, Mitelman F: Recurrent chromosome aberrations in abdominal smooth muscle tumors. Cancer Genet Cytogenet 62:43–46, 1992.
Fotiou SK, Tserkezoglou AJ, Mahera H, Konstandinidou AE, Agnantis NJ, Pandis N, Bardi G: Chromosome aberrations and expression of ras and myc oncogenes in leiomyomas and a leiomyosarcoma of uterus. Eur J Gynecol Oncol 13:340–345, 1992.
Fletcher JA, Morton CC, Pavelka K, Lage JM: Chromosome aberrations in uterine smooth muscle tumors: potential diagnostic relevance of cytogenetic instability. Cancer Res 50:4092–4097, 1990.
Nilbert M, Jin Y, Heim S, Mandahl N, Floderus UM, Willen H, Mitelman F: Chromosome rearrangements in two uterine sarcomas. Cancer Genet Cytogenet 44:27–35, 1990.
Boghosian L, Dal Cin P, Turc-Carel C, Rao U, Karakousis C, Sait SJ, Sandberg AA: Three possible cytogenetic subgroups of leiomyosarcoma. Cancer Genet Cytogenet 43:39–49, 1989.
Dal Cin P, Boghosian L, Sandberg AA: t(10; 17) as the sole chromosome change in a uterine leiomyosarcoma. Cancer Genet Cytogenet 32:263–266, 1988.
Havel G, Dahlenfors R, Wedell B, Mark J: Similar chromosomal evolution in a uterine stromomyosarcoma and in one of two leiomyomas from the same patient. APMIS 94:143–146, 1989.
Laxman R, Currie JL, Kurman RJ, Dudzinski M, Griffin CA: Cytogenetic profile of uterine sarcomas. Cancer 71:1283–1288, 1993.
Kajii T, Ohama K: Androgenetic origins of hydatidiform mole. Nature 268:633,634, 1977.
Wake N, Takagi N, Sasaki M: Androgenesis as a cause of hydatidiform mole. J Natl Cancer Inst 60:51, 1978.
Surti U, Szulman AE, O’Brien S: Complete (classic) hydatidiform mole with 46,XY karyotype of paternal origin. Hum Genet 51:153–155, 1979.
Surti U, Szulman AE: Cytogenetics, morphology and clinical outcome of classical and partial hydatidiform moles. Am J Hum Genet 29:104A, 1977.
Szulman AE, Surti U: The syndromes of hydatidiform moles: I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 131:665–671, 1978.
Szulman AE, Surti U: The syndromes of hydatidiform moles: II. Morphologic evolution. Am J Obstet Gynecol 132:20–27, 1978.
Jacobs PA, Angell RR, Buchanan IM, Hassold TJ: The origin of human triploids. Ann Hum Genet 42:49–57, 1978.
Szulman, AE, Surti U: Clinico-pathological profile of partial hydatidiform mole. Obstet Gynecol 59:597–602, 1982.
Doshi N, Surti U, Szulman AE: Morphologic anomalies in triploid liveborn fetuses. Hum Pathol 14:716–723, 1983.
Jacobs PA, Wilson CM, Sprenkle JA, et al.: Mechanism of origin of complete hydatidiform moles. Nature 286:714–716, 1980.
Lawler SD, Povey S, Fisher RA, et al.: Genetic studies on hydatidiform moles II. The origin of complete moles. Ann Hum Genet 46:209, 1982.
Lawler SD, Fisher RA, Pickthall VJ, et al.: Genetic studies on hydatidiform moles I. The origin of partial moles. Cancer Genet Cytogenet 5:309–320, 1982.
Ohama K, Kajii T, Okamoto E, et al.: Dispermic origin of XY hydatidiform moles. Nature 292:551–552, 1981.
Surti U, Szulman AE, O’Brien S: Dispermic origin and clinical outcome of three complete hydatidiform moles with 46,XY karyotype. Am J Obstet Gynecol 144:84–87, 1982.
Surti U, Szulman AE, Wagner K, Leppert M, White R, O’Brien S: Two tetraploid partial hydatidiform moles with triple paternal contribution and 92,XXXY karyotype. Hum Genet 72:15–21, 1986.
Vejerslev LO, Fisher RA, Surti U, Wake N: Hydatidiform mole: cytogeneti-cally unusual cases: implications for the present classification. Am J Obstet Gynecol 157:180–184, 1987.
Wallace DC, Surti U, Adams C, Szulman AE: Complete moles have paternal chromosomes but maternal mitochondrial DNA. Hum Genet 61:145–147, 1982.
Wake N, Tanaka K, Chapman V, Metsui S, Sandberg AA: Chromosomes and cellular origin of choriocarcinoma. Cancer Res 41:3137–3143, 1981.
Sheppard DM, Fisher RA, Lawler SD: Karyotypic analysis and chromosome polymorphisms in four choriocarcinoma cell lines. Cancer Genet Cytogenet 16:251–258, 1985.
Habibian R, Surti U: Cytogenetics of trophoblasts from complete hydatidiform moles. Cancer Genet Cytogenet 29:271–287, 1987.
Surti U, Habibian R: Chromosomal rearrangement in choriocarcinoma cell lines. Cancer Genet Cytogenet 38:229–240, 1989.
Bettio D, Giardino D, Rizzi N, Simoni G: Cytogenetic abnormalities detected by direct analysis in a case of choriocarcinoma. Cancer Genet Cytogenet 68:149–151, 1993.
Surti U, Juda S, Krishnan S, Alavizadeh S, Leger W: Characterization of chromosomes 7 and 12 abnormalities in gestational choriocarcinoma. Am J Hum Genet 51:4, 1992
Fisher RA, Paradinas FJ, Newland ES, Boxer GM: Genetic evidence that placental site trophoblastic tumours can originate from a hydatidiform mole or a normal conceptus. Br J Cancer 65:355–358, 1992.
Arima T, Imamura T, Amada S, Tsuneyoshi M, Wake N: Genetic origin of malignant trophoblastic neoplasms. Cancer Genet Cytogenet 73:95–102, 1994.
Hashimoto K, Azuma C, Koyama M, Ohashi K, Kamiura S, Nobunaga T, Kimura T, Tokugawa Y, Kanai T, Saji F: Loss of imprinting in choriocarcinoma. Nature Genetics 9:109, 110, 1995.
Damjanov I: The pathology of human teratomas. In: Damjanov I, Knowles BB, Solter D (eds.), The Human Teratoma: Experimental and Clinical Biology. Clifton, NJ: Humana Press, pp. 23–54, 1983.
Surti U, Hoffner L, Chakravarti A, Ferrell R: Genetics of human ovarian teratomas: I. Cytogenetic analysis and mechanism of origin. Am J Human Genet 47:635–643, 1990.
Hoffner L, Deka R, Chakravarti A, Surti U: Cytogenetics and origin of pediatric germ cell tumors. Cancer Genet Cytogenet 74:54–58, 1994.
Climie ARW, Health LP: Malignant degeneration of benign cystic teratomas of the ovary. Review of the literature and report of a chondrosarcoma and carcinoid tumor. Cancer 22:824–832, 1968.
Tobon H, Surti U, Naus GJ, Hoffner L, Hemphill RW: Squamous cell carcinoma in situ arising in an ovarian mature cystic teratoma: report of one case with histopathologic, cytogenetic and flow cytometric DNA content analysis. Arch Pathol Lab Med 115:172–174, 1991.
Peterson WF, Prevost EC, Edmunds FT, Huntly JM, Morris FK: Benign cystic teratomas of the ovary: a clinicostatistical study of 1007 cases with a review of the literature. Am J Obstet Gynecol 70:368–382, 1995.
Linder D, Power J: Further evidence of post-meiotic origin of teratomas in the human female. Ann Hum Genet 34:21–30, 1970.
Patil S, Kaiser-McCaw B, Hecht F, Linder D, Lovrien E: Human benign ovarian teratomas: chromosomal and electrophoretic enzyme studies. Birth Defects Orig Article Ser 14:297–301, 1978.
Linder D, McCaw BK, Hecht F: Parthenogenic origin of benign ovarian teratomas. N Engl J Med 292:63–66, 1975.
Carritt B, Parrington JM, Welch HM, Povey S: Diverse origins of multiple ovarian teratomas in a single individual. Proc Natl Acad Sci USA 79: 7400–7404, 1982.
Parrington J, West L, Povey S: The origin of ovarian teratomas. J Med Genet 21:4–12, 1984.
Ohama K: Androgenesis and parthenogenesis in humans. In: Vogel F, Springer K (eds.), Human Genetics. Berlin, Germany: Springer, pp. 245–249, 1987.
Deka R, Chakravarti A, Surti U, Hauselman E, Reefer J, Majumder PP, Ferrell RE: Genetics and biology of human ovarian teratomas: II. Molecular analysis of origin of non-disjunction and gene-centromere mapping of chromosome 1 markers. Am J Hum Genet 47:644–655, 1990.
Chakravarti A, Majumder PP, Slaugenhaupt SA, Deka R, Warren AC, Surti U, Ferrell RE, et al.: Gene-centromere mapping and the study of non-disjunction in autosomal trisomies and ovarian teratomas. In: Hassold TJ, Epstein CJ (eds.), Molecular and Cytogenetic Studies of Non-Disjunction. New York: Liss, pp. 45–79, 1989.
Warren AC, Chakravarti A, Wong C, Slaugenhaupt SA, Halloran SL, Watkins PC, Metaxotous C, Antonarakis SE: Evidence for reduced recombination on the nondisjoined chromosomes 21 in Down syndrome. Science 237:652–654, 1987.
Dahl N, Gustavson K-H, Rune C, Gustavsson I, Pettersson U: Benign ovarian teratomas-an analysis of their cellular origin. Cancer Genet Cytogenet 46:115–123, 1990.
Arias-Bernal L: Chromosomes of a malignant ovarian teratoma. Am J Obstet Gynecol 100:785–789, 1968.
Serr DM, Padeh B, Mashiach S, Shaki R: Chromosomal studies in tumors of embryonic origin. Obstet Gynecol 33:324–332, 1969.
Atkin NB, Baker MC, Robinson R, Gage SE: Chromosome studies in 14 near-diploid carcinomas of the ovary. Eur J Cancer 10:143–146, 1974.
Kusyk CJ, Terpening EL, Edwards CL, Wharton JT, Copeland LJ: Karyotype analysis of four solid gynecologic tumors. Gynecol Oncol 14:324–338, 1982.
Ihara T, Ohama K, Satoh M, Fujii T, Nomura K, Fujiwara A: A histologic grade and karyotype of immature teratoma of the ovary. Cancer 54:2944–2988, 1984.
Yang-Feng TL, Katz SN, Cacanjiu ML, Schwartz PE: Cytogenetic analysis of ependymoma and teratoma of the ovary. Cancer Genet Cytogenet 35:83–89, 1988.
King ME, DiGiovanni LM, Yung J-F, Clarke-Pearson DL: Immature teratoma of the ovary Grade 3 with karyotype analysis. Int J Gyn Pathol 9:178–184, 1990.
Gibas Z, Talerman A: Cytogenetic analysis of a metastatic immature teratoma of the ovary: Abstract No. B22. Fourth International Workshop on Chromosomes in Solid Tumors. Tucson, Arizona, 1991.
Jenkyn DJ, McCartney AJ: A chromosome study of three ovarian tumors. Cancer Genet Cytogenet 26:327–337, 1987.
Hoffner L, Shen-Schwarz S, Deka R, Chakravarti A, Surti U: Genetics and biology of human ovarian teratomas. III. Cytogenetics and origin of malignant ovarian germ cell tumors. Cancer Genet Cytogenet 62:58–65, 1992.
Oosterhuis JW, Looijenga LHJ, van Kessel AG, de Jong B: A cytogenetic classification of germ cell tumors and its biological relevance. Eur Urol 23:6–8, 1993.
Atkin NB, Baker MC: Abnormal chromosomes including small metacentric in 14 human ovarian cancers. Cancer Genet Cytogenet 26:355–361, 1987.
Speleman F, DePotter C, Dal Cin P, Mangelschots K, Ingelaere H, Laurey G, Benoit Y, Leroy J, Van den Berghe H: I(12p) in a malignant ovarian tumor. Cancer Genet Cytogenet 45:49–53, 1990.
Speleman F, Laureys G, Benoit Y, Cuvelier C, Suikerbuijk R, DeJong B: I(12p) in a near-diploid mature ovarian teratoma. Cancer Genet Cytogenet 60:216–218, 1992.
Ohama K, Normua K, Okamoto E, Fukuda Y, Ihara T, Fujiwara A: Origin of immature teratoma of the ovary. Am J Obstet Gynecol 152:869–890, 1985.
Barton SC, Surani MAH, Norris ML: Role of paternal and maternal genomes in mouse development. Nature 311:374–376, 1984.
Driscoll DJ, Waters MF, Williams CA, Zori RT, Glenn CC, Avidano KM, Nicholls RD: A DNA methylation imprint, determined by the sex of the parent, distinguishes the Angelman and Prader-Willi syndromes. Genomics 13:917–924, 1992.
Mowery-Rushton PA, Driscoll DJ, Nicholls RD, Locker J, Surti U: DNA methylation patterns in human tissues of uniparental origin using a zinc-finger gene (ZNF127) from the Angelman/Prader-Willi region. Am J Med Genet 61:140–146, 1996.
Feinberg AP, Rainier S, DeBaun MR: Genomic imprinting, DNA methylation, and cancer. J Natl Cancer Inst Monogr 17:21–26, 1995.
Wutz A, Smrzka OW, Barlow DP, Neumann B: Genomic imprinting: the parental connection. Appl Cytogenet 21:145–152, 1995.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Humana Press Inc.
About this chapter
Cite this chapter
Surti, U., Hoffner, L. (1997). Cytogenetic Markers in Selected Gynecological Malignancies. In: Wolman, S.R., Sell, S. (eds) Human Cytogenetic Cancer Markers. Contemporary Biomedicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-3952-9_9
Download citation
DOI: https://doi.org/10.1007/978-1-4612-3952-9_9
Publisher Name: Humana Press
Print ISBN: 978-1-4612-8437-6
Online ISBN: 978-1-4612-3952-9
eBook Packages: Springer Book Archive