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Karyotypic Characteristics of Colorectal Tumors

  • Chapter
Human Cytogenetic Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 13))

Abstract

Colorectal cancer is not only one of the most common human malignancies, but one with a high mortality rate. A variety of mechanisms have been implicated in the development of colorectal cancer, including dietary and other environmental as well as genetic factors, especially somatic cell mutations. In spite of the utilization of numerous histopathologic and other tumor markers (1–3), the management of patients with this disease is difficult and prognostication remains notoriously unreliable.

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References

  1. Jass JR, Atkin WS, Cuzick J, Bussey HJR, Morson BC, Northover JMA, Todd IP: The grading of rectal cancer: historical perspective and a multivariate analysis of 447 cases. Histopathology 10:437–459, 1986.

    Article  PubMed  CAS  Google Scholar 

  2. O’Brien MJ, O’Keane CJ, Zauber A, Gottlieb LS, Winawer SJ: Precursors of colorectal carcinoma. Biopsy and biologic markers. Cancer 70: 1317–1327, 1992.

    Article  PubMed  Google Scholar 

  3. Cohen AM, Minsky BD, Schilsky RL: Colon cancer. In: DeVita VT, Hellman S, Rosenberg SA (eds.), Cancer Principles and Practice of Oncology, 4th ed. Philadelphia: Lippincott, pp. 929–977, 1993.

    Google Scholar 

  4. Groden J, Thliveris A, Sanowitz W, Carlson M, Gelbert L, Albertsen H, Joslyn G, Stevens J, Spirio L, Robertson M, Sargeant L, Krapcho K, Wolff E, Burt R, Hughes JP, Warrington J, McPherson J, Le Paslier D, Abderrahim H, Cohen D, Leppert M, White R: Identification and characterization of the familial adenomatous polyposis gene. Cell 66: 587–600, 1991.

    Article  Google Scholar 

  5. Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P, Markham A, Krush AJ, Petersen G, Hamilton SR, Nilbert MC, Levy DB, Bryan TM, Preisinger AC, Smith KJ, Su L-K, Kinzler KW, Vogelstein B: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 253:665–669, 1991.

    Article  PubMed  CAS  Google Scholar 

  6. Hollstein M, Sidransky D, Vogelstein B, Harris CC: P53 mutations in human cancers. Science 253:1366–1370, 1991.

    Article  Google Scholar 

  7. Fearon ER, Cho KR, Nigro JM, Kern SE, Simons JW, Ruppert JM, Hamilton SR, Preisinger AC, Thamas G, Kinzler KW, Vogelstein B: Identification of a chromosome 18q gene that is altered in colorectal cancers. Science 247:49–56, 1990.

    Article  PubMed  CAS  Google Scholar 

  8. Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759–767, 1990.

    Article  PubMed  CAS  Google Scholar 

  9. Foulds L: The natural history of cancer. J Chronic Dis 8:2–37, 1958.

    Article  PubMed  CAS  Google Scholar 

  10. Heim S: Is cancer cytogenetics reducible to the molecular genetics of cancer cells? Genes Chromosome Cancer 5:188–196, 1992.

    Article  CAS  Google Scholar 

  11. Mitelman F: Catalog of Chromosome Aberrations in Cancer, 5th ed. New York: Wiley-Liss, 1994.

    Google Scholar 

  12. Reichmann A, Martin P, Levin B: Chromosomal banding patterns in human large bowel cancer. Int J Cancer 28:431–440, 1981.

    Article  PubMed  CAS  Google Scholar 

  13. Muleris M, Salmon R-J, Duttrillaux B: Cytogenetics of colorectal adenocarcinomas. Cancer Genet Cytogenet 46:143–156, 1990.

    Article  PubMed  CAS  Google Scholar 

  14. Bardi G, Sukhikh T, Pandis N, Fenger C, Kronborg O, Heim S: Karyotypic characterization of colorectal adenocarcinomas. Genes Chrom Cancer 12:97–109, 1995.

    Article  PubMed  CAS  Google Scholar 

  15. Shroy P, Cohen A, Winawer S, Friedman E: New chemotherapeutic drug sensitivity for colon carcinomas in monolayer culture. Cancer Res 48: 3236–3244, 1988.

    Google Scholar 

  16. Friedman E, Isaksson P, Rafter J, Marian B, Winawer S, Newmark H: Fecal diglycerides as selective endogenous mitogens for premalignant and malignant human colonic epithelial cells. Cancer Res 49:544–548, 1988.

    Google Scholar 

  17. Bardi G, Johansson B, Pandis N, Bak-Jensen E, Örndal C, Heim S, Mandahl N, Andrén-Sandberg Å, Mitelman F: Cytogenetic aberrations in colorectal adenocarcinomas and their correlation with clinicopathologic features. Cancer 71:306–314, 1993.

    Article  PubMed  CAS  Google Scholar 

  18. Bauer KD, Lincoln ST, Vera-Roman JM, Wallemark CB, Chmiel JS, Madurski ML: Prognostic implication of proliferative activity and DNA ane-uploidy in colonic adenocarcinomas. Lab Invest 57:329–335, 1987.

    PubMed  CAS  Google Scholar 

  19. Halvorsen TB, Johannesen E: DNA ploidy, tumor site, and prognosis in colorectal cancer: A flow cytometric study of parafin-embedded tissue. Scand J Gastroenterol 25:141–148, 1990.

    Article  PubMed  CAS  Google Scholar 

  20. Ferti AD, Panani AD, Raptis S: Cytogenetic study of rectosigmoidal adenocarcinomas. Cancer Genet Cytogenet 34:101–109, 1988.

    Article  PubMed  CAS  Google Scholar 

  21. Konstantinova LN, Fleishman EW, Knisch VI, Perevozchikov AG, Kopnin BP: Karyotype peculiarities of human colorectal adenocarcinomas. Hum Genet 86:491–496, 1991.

    Article  PubMed  CAS  Google Scholar 

  22. Wang L, Li L, Zhou HY, Gao XK, Li SJ: t(13q;17p) and del(5q): possibly specific changes in Chinese patients with colorectal cancers. Cancer Genet Cytogenet 62:191–196, 1992.

    Article  PubMed  CAS  Google Scholar 

  23. Pandis N, Bardi G, Heim S: Interrelationship between methodological choices and conceptual models in solid tumor cytogenetics. Cancer Genet Cytogenet 76:77–84, 1994.

    Article  PubMed  CAS  Google Scholar 

  24. Mitelman F, Mark J, Nilsson PG, Dencker H, Norryd C, Tranberg K-G: Chromosome banding pattern in human colonic polyps. Hereditas 78: 63–68, 1974.

    Article  PubMed  CAS  Google Scholar 

  25. Reichmann A, Martin P, Levin B: Chromosomal banding patterns in human large bowel adenomas. Hum Genet 70:28–31, 1985.

    Article  PubMed  CAS  Google Scholar 

  26. Couturier-Turpin M-H, Esnous C, Louvel A, Poirier Y, Couturier D: Chromosome 1 in human colorectal tumors. Hum Genet 88:431–438, 1992.

    Article  PubMed  CAS  Google Scholar 

  27. Bardi G, Pandis N, Fenger C, Kronborg O, Bomme L, Heim S: Deletion of 1p36 as a primary chromosomal aberration in intestinal tumorigenesis. Cancer Res 53:1895–1898, 1993.

    PubMed  CAS  Google Scholar 

  28. Griffin CA, Lazer S, Hamilton SR, Giardiello FM, Long P, Krush AJ, Booker SV: Cytogenetic analysis of intestinal polyps in polyposis syndromes: Comparison with sporadic adenomas. Cancer Genet Cytogenet 67:14–20, 1993.

    Article  PubMed  CAS  Google Scholar 

  29. Longy M, Saura R, Dumas F, Leseve J-F, Taine L, Goussot J-F, Couzigou P: Chromosome analysis of adenomatous polyps of the colon: possible existence of two differently evolving cytogenetic groups. Cancer Genet Cytogenet 67:7–13, 1993.

    Article  PubMed  CAS  Google Scholar 

  30. Bomme L, Bardi G, Pandis N, Fenger C, Kronborg O, Heim S: Clonal karyotypc abnormalities in colorectal adenomas: clues to the early events in the adenoma-carcinoma sequence. Genes Chrom Cancer 10:190, 1994.

    Article  PubMed  CAS  Google Scholar 

  31. Muleris M, Zafrani B, Validire P, Girodet J, Salmon R-J, Dutrillaux B: Cytogenetic study of 30 colorectal adenomas. Cancer Genet Cytogenet 74:104–108, 1994.

    Article  PubMed  CAS  Google Scholar 

  32. Bardi G, Johansson B, Pandis N, Heim S, Mandahl N, Andren-Sandbeg Å, Hägerstrand I, Mitelman F: Trisomy 7 in short-term cultures of colorectal adenocarcinomas. Genes Chrom Cancer 3:149–152, 1991.

    Article  PubMed  CAS  Google Scholar 

  33. Johansson B, Heim S, Mandahl N, Mertens F, Mitelman F: Trisomy 7 in nonneoplastic cells. Genes Chrom Cancer 6:199–205, 1993.

    Article  PubMed  CAS  Google Scholar 

  34. Bardi G, Pandis N, Heim S: Trisomy 7 as the sole cytogenetic aberration in the epithelial component of a colonic adenoma. Cancer Genet Cytogenet 82:82–84, 1995.

    Article  PubMed  CAS  Google Scholar 

  35. Herbergs J, de Bruine AP, Marx PTJ, Vallinga MIJ, Stockbrugger RW, Ramaekers FCS, Arends JW, Hopman AHN: Chromosome aberrations in adenomas of the colon. Proof of trisomy 7 in tumor cells by combined interphase cytogenetics and immunocytochemistry. Int J Cancer 57:781–785, 1994.

    Article  PubMed  CAS  Google Scholar 

  36. Becher R, Gibas Z, Sandberg AA: Involvement of chromosome 7 and 12 in large bowel cancer: trisomy 7 and 12q-. Cancer Genet Cytogenet 9:329–332, 1983.

    Article  PubMed  CAS  Google Scholar 

  37. Ochi H, Takeuchi J, Holyoke D, Sandberg AA: Possible specific changes in large bowel cancer. Cancer Genet Cytogenet 10:121, 122, 1983.

    Article  PubMed  CAS  Google Scholar 

  38. Schweinfest CW, Henderson KW, Suster S, Kondoh N, Papas TS: Identification of a colon mucosa gene that is down regulated in colon adenomas and adenocarcinomas. Proc Natl Acad Sci USA 90:4166–4170, 1993.

    Article  PubMed  CAS  Google Scholar 

  39. Tagushi T, Testa JR, Papas TS, Schweinfest C: Localization of a candidate colon tumor suppressor gene (DRA) to 7q22-q31.1 by fluorescence in situ hybridization. Genomics 20:146, 147, 1994.

    Google Scholar 

  40. Fox M, Lahib F, Pratt W, Attwood J, Gum J, Kim Y, Swallow DM: Regional localization of MUC3 to chromosome 7q22. Cytogenet Cell Genet 58:1920, 1921, 1991.

    Google Scholar 

  41. Couturier-Turpin MH, Louvel A, Couturier D, Esnous C, Poirier Y, Nepveux P: Tubulovillous adenoma of the colon with hyperdiploidy, double minute chromosomes, and inversion of chromosome 1. Cancer Genet Cytogenet 32:253–262, 1988.

    Article  PubMed  CAS  Google Scholar 

  42. Tanaka K, Yanoshita R, Konishi M, Oshimura M, Maeda Y, Mori T, Miyaki M: Suppression of tumorigenicity in human colon carcinoma cells by introduction of normal chromosome 1p36 region. Oncogene 8:2253–2258, 1993.

    PubMed  CAS  Google Scholar 

  43. Dietrich WF, Lander E, Smith JS, Moser AR, Gould K, Luongo C, Borenstein N, Dove W: Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse. Cell 75:631–639, 1993.

    Article  PubMed  CAS  Google Scholar 

  44. Lothe RA, Andersen SN, Hofstad B, Meling GI, Peltomäki P, Heim S, Brøgger A, Vatn M, Rognum TO, Børresen A-L: Deletion of 1p loci and microsatellite instability in colorectal polyps. Genes Chrom Cancer 14:182–188, 1995.

    Article  PubMed  CAS  Google Scholar 

  45. Jass JR, Path MRC: Do all colorectal carcinomas arise in preexisting adenomas? World J Surg 13:45–51, 1989.

    Article  PubMed  CAS  Google Scholar 

  46. Longacre TA, Fenoglio-Preiser CM: Mixed hyperplastic adenomatous polyps/serrated adenomas. A distinct form of colorectal neoplasia. Am J Surg Pathol 14:524–537, 1990.

    Article  PubMed  CAS  Google Scholar 

  47. Hamilton SR: The adenoma-adenocarcinoma sequence in the large bowel: variations on a theme. J Cell Biochem 6G (Suppl 1):41–46, 1992.

    Article  Google Scholar 

  48. Reichmann A, Levin B, Martin P: Human large-bowel cancer: correlation of clinical and histological features with banded chromosomes. Int J Cancer 29:625–629, 1982.

    Article  PubMed  CAS  Google Scholar 

  49. Delattre O, Olschwang S, Law DJ, Melot T, Remvikos Y, Salmon RJ, Sastre X, Validire P, Feinberg AP, Thomas G: Multiple genetic alterations in distal and proximal colorectal cancer. Lancet 11:353–355, 1989.

    Article  Google Scholar 

  50. Barretton G, Gille J, Oevermann E: Flow cytometric analysis of the DNA content in paraffin-embedded tissue from colorectal carcinomas and its prognostic significance. Virchows Arch B Cell Pathol 60:123, 1991.

    Article  Google Scholar 

  51. Costa A, Faranda A, Scalmati A: Autoradiographic and flow cytometric assessment of cell proliferation in primary colorectal cancer: relationship to DNA ploidy and clinicopathologic features. Int J Cancer 50:719, 1992.

    Article  PubMed  CAS  Google Scholar 

  52. Lanza G, Maestri I, Ballotta MR, Dubini A, Cavazzini L: Relationship of nuclear DNA content to clinicopathologic features in colorectal cancer. Modern Pathol 7:161–165.

    Google Scholar 

  53. Bufill JA: Colorectal cancer: evidence for distinct genetic categories based on proximal or distal tumor location. Ann Intern Med 113:779–788, 1990.

    PubMed  CAS  Google Scholar 

  54. Bardi G, Johansson B, Pandis N, Mandahl N, Bak-Jensen E, Lindström C, Törnqvist A, Frederiksen H, Andrén-Sandberg Å, Mitelman F, Heim S: Cytogenetic analysis of 52 colorectal carcinomas: non-random aberration pattern and correlation with pathologic parameters. Int J Cancer 55:422–428, 1993.

    Article  PubMed  CAS  Google Scholar 

  55. Jass JR: The large intestine. In: Morson BC (ed.), Alimentary Tract. Edinburgh; UK: Churchill Livingstone, pp. 313–395, 1987.

    Google Scholar 

  56. Laurent-Puig P, Olschwang S, Delattre O, Remvikos Y, Asselain B, Melot T, Validire P, Muleris M, Girodet J, Salmon R, Thomas G: Survival and acquired genetic alterations in colorectal cancer. Gastroenterol 102:1136–1141, 1992.

    CAS  Google Scholar 

  57. Baker SJ, Preisinger AC, Jessup JM, Paraskeva C, Markowitz S, Willson JKV: p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res 50:7717–7722, 1990.

    PubMed  CAS  Google Scholar 

  58. Hamilton SR: Molecular genetics of colorectal cancer. Cancer 70:1216–1221, 1992.

    Article  PubMed  CAS  Google Scholar 

  59. Cho KR, Vogelstein B: Genetic alterations in the adenoma-carcinoma sequence. Cancer 70:1727–1731, 1992.

    Article  PubMed  CAS  Google Scholar 

  60. Bodmer W, Bishop T, Karran P: Genetic steps in colorectal cancer. Nature Genet 6:217–219, 1994.

    Article  PubMed  CAS  Google Scholar 

  61. Kouri M, Laasonen A, Mecklin JP, Jarvinen H, Franssila K, Pyrhonen S: Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry. Cancer 65:1825–1829, 1990.

    Article  PubMed  CAS  Google Scholar 

  62. Aaltonen LA, Peltomäki P, Leach FS, Sistonen P, Pylkkanen L, Mecklin J-P, Jarvinen H, Powell SM, Jen J, Hamilton SR, Petersen GM, Kinzler KW, Vogelstein B, de la Chapelle A: Clues to the pathogenesis of familial colorectal cancer. Science 260:812–816, 1993.

    Article  PubMed  CAS  Google Scholar 

  63. Bronner CE, Baker SM, Morrison PT, Warren G, Smith LG, Lescoe MK, Kane M, Earabino C, Lipford J, Lindblom A, Tannergarg P, Bollag RJ, Godwin AR, Ward DC, Nordenskiold M, Fishel R, Kolodner R, Liskay RM: Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer. Nature 368:258–261, 1994.

    Article  PubMed  CAS  Google Scholar 

  64. Nicolaides NC, Papadopoulos N, Liu B, Wei Y-F, Carter KC, Ruben S, Rosen CA, Haseltine WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Dunlop MG, Hamilton SR, Petersen GM, de la Chapelle A, Vogelstein B, Kinzler KW: Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371:75–80, 1994.

    Article  PubMed  CAS  Google Scholar 

  65. Papadopoulos N, Nicolaides NC, Wei Y-F, Ruben SM, Carter KC, Rosen CA, Haseline WA, Fleischmann RD, Fraser CM, Adams MD, Venter JC, Hamilton SR, Petersen GM, Watson P, Lynch HT, Peltomäki P, Mecklin J-P, de la Chapelle A, Kinzler KW, Vogelstein B: Mutation of a mutL homolog in hereditary colon cancer. Science 263:1625–1629, 1994.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. Georgia Bardi
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  2. Nikos Pandis
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  3. Felix Mitelman
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  4. Sverre Heim
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Editor information

Editors and Affiliations

  1. Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Sandra R. Wolman MD

  2. Department of Pathology, Albany Medical College, Albany, NY, USA

    Stewart Sell MD

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© 1997 Humana Press Inc.

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Bardi, G., Pandis, N., Mitelman, F., Heim, S. (1997). Karyotypic Characteristics of Colorectal Tumors. In: Wolman, S.R., Sell, S. (eds) Human Cytogenetic Cancer Markers. Contemporary Biomedicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-3952-9_7

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  • DOI: https://doi.org/10.1007/978-1-4612-3952-9_7

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8437-6

  • Online ISBN: 978-1-4612-3952-9

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