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Direct Demonstration of Lineage Specificity in Hematologic Neoplasms

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Human Cytogenetic Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 13))

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Abstract

Approximately 150 recurrent chromosomal aberrations have been described in hematologic neoplasms (1). Many are associated with certain morphologic, immunologic, or clinical subtypes of leukemia and lymphoma. Some are of clear-cut biological importance, and about 50 specific translocations and inversions have been shown to cause gene fusions that activate cancer genes (2). To investigate the fundamental biological question of stem cells, and in view of therapeutic considerations, it is essential to identify the malignant cells among the numerous cell types in the hematopoietic system. Chromosomal aberrations are excellent cancer-specific markers. Phenotypic markers can be also used to characterize the cell lineages and stages of differentiation of malignant cells. Hematopoietic cells and malignancies are typically classified according to cell morphology and immunophenotype (3).

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Authors
  1. Sakari Knuutila
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Editors and Affiliations

  1. Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Sandra R. Wolman MD

  2. Department of Pathology, Albany Medical College, Albany, NY, USA

    Stewart Sell MD

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© 1997 Humana Press Inc.

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Knuutila, S. (1997). Direct Demonstration of Lineage Specificity in Hematologic Neoplasms. In: Wolman, S.R., Sell, S. (eds) Human Cytogenetic Cancer Markers. Contemporary Biomedicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-3952-9_5

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  • DOI: https://doi.org/10.1007/978-1-4612-3952-9_5

  • Publisher Name: Humana Press

  • Print ISBN: 978-1-4612-8437-6

  • Online ISBN: 978-1-4612-3952-9

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