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Pancreatic Exocrine Tumors

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Book cover Human Cytogenetic Cancer Markers

Part of the book series: Contemporary Biomedicine ((CB,volume 13))

Abstract

The most common tumor arising from the exocrine pancreas is adenocarcinoma. Currently the fifth leading cause of cancer death in the United States (1), the overall 5-yr survival rate for this cancer is <5%. Most tumors occur in the head of the pancreas and symptoms include jaundice, weight loss, and abdominal pain. Patients with localized tumors who undergo resection (pancreaticoduodenectomy) have a 5-yr survival rate approaching 20%; positive prognostic signs include the absence of metastases to lymph nodes, negative resection margins, tumor size <2 cm, absence of blood vessel invasion, and diploid DNA content (2–6). The ability to diagnose accurately an intrabdominal carcinoma as pancreatic in origin by fine needle aspiration and one or several molecular diagnostic tests would be a valuable aid to the clinical managment of this aggressive neoplasm. Similarly, prognosticators that could be determined prior to surgery in patients might allow appropriate decisions to be made regarding which patients are most likely to benefit from aggressive surgery and which from experimental therapy. It is likely that elucidation of genetic changes will provide such information. The goal of this chapter is to review known genetic alterations in pancreatic cancer.

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Authors
  1. Constance A. Griffin
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Editors and Affiliations

  1. Department of Pathology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA

    Sandra R. Wolman MD

  2. Department of Pathology, Albany Medical College, Albany, NY, USA

    Stewart Sell MD

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Griffin, C.A. (1997). Pancreatic Exocrine Tumors. In: Wolman, S.R., Sell, S. (eds) Human Cytogenetic Cancer Markers. Contemporary Biomedicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-3952-9_15

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  • DOI: https://doi.org/10.1007/978-1-4612-3952-9_15

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