Abstract
Skin is one of the largest vital organs, covering the human body. The skin is embryologically derived from ectoderm and mesoderm. Epithelial structures emanate from the ectoderm, nerves and melanocytes from the neuroectoderm, and the mesenchymal component from the mesoderm. The skin consists of three layers: a resistant and impermeable outermost layer known as the epidermis; a tough, durable but porous, connective tissue layer called the dermis; and a soft, lipid-rich, deep layer, the subcutis. The cutaneous adnexa (hair follicles, sweat glands) complement the basic function of the skin.
Keywords
- Squamous Cell Carcinoma
- Basal Cell Carcinoma
- Metastatic Melanoma
- Merkel Cell Carcinoma
- Melanocytic Nevus
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References
Penneys NS, Fulton JE, Weinstein GD, et al: Location of proliferating cells in human epidermis. Arch Dermatol 101:323–327, 1970.
Halprin KM: Epidermal turnover time. A reexamination. Br J Dermatol 86:14–19, 1972.
Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell 61:759–767, 1990.
Ledbetter DH, Cavanee WK: Molecular cytogenetics: Interface of cytogenetics and monogenic disorders. In: Schriver CR, Beaudet AL, Sly WS, Valle D. (eds.), The Metabolic Basis of Inherited Disease, Sixth ed. New York: McGraw-Hill, pp. 343–371, 1989.
Pardue ML, Gall JG: Molecular hybridization of radioactive DNA to the RNA of cytological preparations. Proc Natl Acad Sci USA 64:600–604, 1969.
SEER Cancer Statistics Review, 1973–1991. National Institutes of Health. National Cancer Institute, Bethesda, MD, June 1994.
Kwa RE, Campana K, Moy RL: Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol 26:1–26, 1992.
Miller SJ: Biology of basal cell carcinoma (Part 1). J Am Acad Dermatolol 24:1–13, 1991.
Miller SJ: Biology of basal cell carcinoma (Part 2). J Am Acad Dermatol 24:161–175, 1991.
Marks R, Rennie G, Selwood TS: Malignant transformation of solar keratoses to squamous cell carcinoma. Lancet 1:795, 796, 1988.
Mertens F, Jin Y, Heim S, Mandahl N, Honsson N, Mertens O, Persson B, Salemark L, Wennerberg J, Mitelman F: Clonal structural chromosomal aberrations in nonneoplastic cells of the skin and upper aerodigestive tract. Genes Chromosome Cancer 4:235–240, 1992.
Pavarino EC, Antonio JR, Pozzeti EM, Larranaga A, Tajara EH: Cytogenetic study of neoplastic and nonneoplastic cells of the skin. Cancer Genet Cytogenet 85:16–19, 1995.
Hoehn H. Bryant EM, Au K, Norwood TH, Boman H, Martin GM: Variegated translocation mosaicism in human skin fibroblast cultures. Cytogenet Cell Genet 15:282–298, 1982.
Littlefield LG, Mailhes JB: Observations of de novo clones of cytogeneti-cally aberrant cells in primary fibroblast cell strains from phenotypically normal women. Am J Hum Genet 27:190–197, 1975.
Harnden DG, Benn PA, Oxford JM, Taylor AMR, Webb TP: Cytogenetically marked clones in human fibroblasts cultured from normal subjects. Somat Cell Genet 2:55–62, 1976.
Salk D, Au K, Hoehn H, Martin GM: Cytogenetics of Werners’s syndrome cultured skin fibroblasts: variegated translocation mosaicism. Cytogenet Cell Genet 30:92–107, 1981.
Mertens F, Johansson B: No increased chromosome breakage in skin fibroblasts from patients with musculoskeletal sarcoma. Clin Genet 34: 20–25, 1988.
Happle R, Hoehn H: Cytogenetic studies on cultured fibroblast-like cells derived from basal cell carcinoma tissue. Clin Genet 4:17–24, 1973.
Taylor AMR, Harnden DG, Fairburn EA: Chromosomal instability associated with susceptibility to malignant disease in patients with porokeratosis of Mibelli. J Natl Cancer Inst 51:371–378, 1973.
Salk D: Werner’s syndrome. A review of recent research with an analysis of connective tissue metabolism, growth control of cultured eels, and chromosomal aberrations. Hum Genet 62:1–5, 1982.
Scappaticci S, Fraccaro M, Orecchia G: Multiple clonal chromosome abnormalities ina superficial basal cell epithelioma. Cancer Genet Cytogenet 42:309–311, 1989.
Scappaticci S, Lambiase S, Fraccaro M, Orecchi G: Cancer Genet Cytogenet 43:249, 250, 1989.
Benn PA: Specific chromosome aberrations in senescent fibroblast cell lines derived from human embryos. Am J Human Genet 28:465–473, 1976.
Visfeldt J: Clone formation in tissue culture. Experience from long-term cultures of irradiated human skin. Acta Pathol Microbiol Scand 68: 305–312, 1966.
Bigger TRL, Savage JRK, Watson GE: A scheme for characterizing ASG banding and an illustration of its use in identifying complex chromosomal rearrangements in irradiated human skin. Chromosoma 39:297–309, 1972
Savage JRK, Bigger TRL: Aberration distribution and chromosomally marked clones in x-irradiated skin. In: Evans HJ, Lloyd DC, (eds), Mutagen-lnduced Chromosome Damage in Man. Edinburgh U.K. Edinburgh University, pp. 155–169, 1978.
Garewal HS, Sampliner R, Liu Y, Trent JM: Chromosomal rearrangements in Barrett’s esophagus. A premalignant lesion of esophageal adenocarcinoma. Cancer Genet Cytogenet 42:281–286, 1989.
Whang-Peng J, Banks-Schlegel SP, Lee EC: Cytogenetic studies of esophageal carcinoma cell lines. Cancer Genet Cytogenet 45:101–120, 1990.
Viegas-Pequignot E, Flury-Herard A, De Cremoux H, Chlecq C, Bignon J, Dutrillaux G: Recurrent chromosome aberrations in human lung squamous cell carcinomas. Cancer Genet Cytogenet 49:37–49, 1990.
Worsham MJ, Van Dyke DL, Grenman SE, Grenman R, Hopkins MA, Roberts JA, Gasser KM, Schwartz DR, Carey TE: Consistent chromosome abnormalities in squamous carcinoma of the vulva. Genes Chromosomes Cancer 3:420–432, 1991.
Heo DS, Snyderman C, Gollin SM, Pan S, Walker E, Deka R, Barnes EL, Johnson JT, Herberman RB, Whiteside TL: Biology, cytogenetics, and sensitivity to immunological effector cells of new head and neck squamous cell carcinoma lines. Cancer Res 49:5167–5175, 1989.
Jin Y, Heim S, Mandahl N, Biorklund A, Wennerberg J, Mitelman F: Multiple apparently unrelated clonal chromosome abnormalities in a squamous cell carcinoma of the tongue. Cancer Genet Cytogenet 32:93–100, 1988.
Jin Y, Mandahl N, Heim S, Biorklund A, Wennerberg J, Mitelman F: Unique karyotypic abnormalites in a squamous cell carcinoma of the larynx. Cancer Genet Cytogenet 30:177–179, 1988.
Jin Y, Mandahl N, Heim S, Biorklund A, Wennerberg J, Mitelman F: t(6;7)as the sole chromosomal anomaly in a vocal cord carcinoma. Cancer Genet Cytogenet 32:305–307, 1988.
Jin Y, Heim S, Mandahl N, Biorklund A, Wennerberg J, Mitelman F: Inversion inv(14)(p15q26) in a squamous cell carcinoma of the hypophar-ynx. Cancer Genet Cytogenet 36:233–234, 1988.
Jin Y, Heim S, Mandahl N, Biorklund A, Wennerberg J, Mitelman F: Multiple clonal chromosome aberrations in squamous cell carcinoma of the larynx. Cancer Genet Cytogenet 44:209–216, 1990.
Jin Y, Heim S, Mandahl N, Biorklund A, Wennerberg J, Mitelman F: Unrelated clonal chromosome aberrations in carcinomas of the oral cavity. Genes Chromosome Cancer 1:209–215, 1990.
Jin Y, Higashi K, Mandahl N, Heim S, Wennerberg J, Bioklund A, Dictor M, Mitelman F: Frequent rearrangement of chromosomal bands lp22 and 11q13 in squamous cell carcinomas of the head and neck. Genes Chromosome Cancer 2:198–204, 1990.
Pejovic T, Heim S, Orndal C, Jin Y, Mandahl N, Willen H, Mitelman F: Simple numerical chromosome aberrations in weli-differentiated malignant epithelial tumors. Cancer Genet Cytogenet 49:95–101, 1990.
Van Dyke DL, Worsham MJ, Benninger MS, Krause CJ, Baker SR, Wolf GT, Drumheller T, Tilley BC, Carey TE: Recurrent cytogenetic abnormalities in squamous cell carcinomas of the head and neck region. Genes Chromosome Cancer 9:192–206, 1994.
Spandidos DA, Lamothe A, Field JK: Multiple transcriptional activation of cellular oncogenes in human head and neck solid tumours. Anticancer Res 5:221–224, 1985.
Tsuda T, Nakatani H, Matsumura T, Yoshida K, Tahara E, Nishihira T, Sakamoto H, Yoshida T, Terada M, Sugimura T: Amplification of the hst-1 gene in human esophageal carcinomas. Jpn J Cancer Res 79:584–588, 1988.
Tsuda T, Nakatani H, Tahara E, Sakamoto H, Terada M, Sugimura T: HST1 and INT2 gene coamplification in a squamous cell carcinoma of the gall bladder. Jpn J Clin Oncol 19:26–29, 1989.
Kitagawa Y, Ueda M, Ando N, et al.: Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma. Cancer Res 51:1504–1508, 1991.
Yamamoto T, Kamata N, Kawano H, et al.: High incidence of amplification of epidermal growth factor receptor gene in human squamous carcinoma cell lines. Cancer Res 46:414–416, 1986.
Wagata T, Ishizaki K, Imamura M, Shimada Y, Ikenaga M, Tobe T: Deletion of 17p and amplification of the int-2 gene in esophageal carcinomas. Cancer Res 51:2113–2117, 1991.
Dolcetti R, Doglioni C, Maestro R, Gasporotto D, Barzan L, Pastore A, Romanelli M, Boiocchi M: p53 overexpression is an early event in the development of human squamous-cell carcinoma of the larynx-genetic and prognostic implications. Int J Cancer 52:178–182, 1992.
Somers KD, Merrick MA, Lopez ME, Incognito LS, Schechter GL, Casey G: Frequent p53 mutations in head and neck cancer. Cancer Res 52:5997–6000, 1992.
Yokoyama S, Yamakawa K, Tsuchiya E, Murata M, Sakiyama S, Nakamura Y: Deletion mapping on the short arm of chromosome 3 in squamous cell carcinoma and adenocarcinoma of the lung. Cancer Res 52:873–877, 1992.
Latif F, Fivash M, Glenn G, Tory K, Orcutt ML, Hampsch K, Dellisio J, Lerman M, Cowan J, Beckett M, Weichselbaum R: Chromosome 3p deletions in head and neck carcinomas: statistical ascertainment of allelic loss. Cancer Res 52:1451–1456, 1992.
Kelker W, Van Dyke DL, Worsham MJ, Christopherson PL, James CD, Conlon MR, Carey TE: Loss of 18q and homozygosity for the DCC locus: possible markers for clinically aggressive squamous cell carcinoma. Anti Cancer Res: in press.
Boynton RF, Huang Y, Blount PL, Reid B J, Raskind WH, Haggitt RC, Newkirk C, Resau JH, Yin J, McDaniel T, Meltzer SJ: Frequent loss of heterozygosity at the retinoblastoma locus in human esophageal cancers. Cancer Res 51:5766–5769, 1996.
Huang Y, Boynton RF, Blount PL, Silverstein RJ, Yin J, Tong Y, McDaniel TK, Newkirk C, Resau JH, Sridhara R, Reid BJ, Meltzer SJ: Loss of heterozygosity involves multiple tumor suppressor genes in human esophageal cancers. Cancer Res 52:6525–6530, 1992.
Heim S, Mandahl N, Mitelman F: Genetic convergence and divergence in tumor progression. Cancer Res 48:5911–5916, 1988.
Heim S, Mertens F, Jin Y, Mandahl N, Johansson B, Biorklund A, Wennerberg J, Jonsson N, Mitelman F: Diverse chromosome abnormalities in squamous cell carcinoma of the skin. Cancer Genet Cytogenet 39: 69–76, 1989.
Slaughter DP, Southwick HW, Smejkal W: “Field cancerization” in oral stratified squamous epithelium: clinical implications of multicentric origin. Cancer 6:963–968, 1953.
Chung KY, Mukhopadhyay T, Kim J, Casson A, Ro JY, Goepfert H, Hong WK, Roth JA: Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodiges-tive tract. Cancer Res 53:1676–1683, 1993.
Smit VT, Cornelisse CJ, De Jong D, et al.: Analysis of tumor heterogeneity in a patient with synchronously occurring female genital tract malignancy by DNA flow cytometry, DNA fingerprinting, and immunohistochemistry. Cancer 62:1146–1152, 1988.
Mertens F, Heim S, Jin Y, Johansson B, Mandahl N, Biorklund A, Wennerberg J, Jonsson N, Mitelman F. Basosquamous papilloma-a benign epithelial skin tumor with multiple cytogenetic clones. Cancer Genet Cytogenet 37:235–239, 1989.
Therapel SA, Lester EP: Two simple translocations in a primary squamous cell carcinoma of the head and neck. Cancer Genet Cytogenet 47:131–134, 1990.
Sen P: Chromosome 9 anomalies as the primary clonal alteration in a case of squamous cell carcinoma of the epiglottis. Cancer Genet Cytogenet 66:23–27, 1993.
Worsham MJ, Benninger MJ, Zarbo RJ, Carey TE, Van Dyke DL: Deletion 9p22-pter and loss of Y as primary chromosome abnormalities in a squamous cell carcinoma of the vocal cord. Genes Chrom Cancer 7:158–164, 1993.
Worsham MJ, Carey TE, Benninger MJ, Gasser KM, Kelker W, Zarbo RJ, Van Dyke DL: Clonal cytogenetic evolution in a squamous cell carcinoma of the skin from a xeroderma pigmentosum patient. Genes Chrom Cancer 7:158–164, 1993.
Jin Y, Mertens F, Mandai N, Heim S, Olegard C, Wennerberg J, Biorklund A, Mitelman F: Chromosome abnormalities in eighty-three head and neck squamous cell carcinomas: influence of culture conditions on karyotypic pattern. Cancer Res 53:2140–2146, 1993.
Jin Y, Mertens F, Jin C, Akervall J, Wennerberg J, Gorunova L, Mandahl N, Heim S, Mitelman F: Non random chromosome abnormalities in short-term cultured primary squamous cell carcinomas of the head and neck. Cancer Res 55:3204–3210, 1995.
Zeigler A, Leffell, DJ, Kumala S, Sharma H, Gailani M, Simon JA, Halperin AJ, Baden HP, Shapiro, PE, Bale AE, Brash DE: Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci USA 90:4216–4220, 1993.
Chiba T, Takahashi T, Nau MM, D’Amico D, Curiel DT, Mitsudomi T, Buchhagen DL, Carbone D, Piantadosi S, Koga H, Reissman PT, Slamon D, Holmes EC, Minna JD: Mutations in the p53 gene are frequent in primary resected, non-small cell lung cancer. Oncogene 5:1603–1610, 1990.
Braun JE, Wanamarta AH, van den Akker E, Lafleur MV, Tetel J: C/G to A/T transversion represent the main type of mutation induced by Y-irradia-tion in double-stranded M13mpl ODNA in a nitrogen-saturated solution. Mutat Res 289:255–263, 1993.
Worsham MJ, Wolman SR, Carey TE, Zarbo RJ, Benninger MS, Van Dyke DL: Common clonal origin of synchronous primary head and neck squamous cell carcinomas: analysis by tumor karyotypes and fluorescence in situ hybridization. Hum Pathol 26:251–261, 1995.
Lever, WF, Schaumburg-Lever G: Histopathology of the skin, 7th ed. Philadelphia, PA: Lippincott, 1990.
Mertens F, Heim S, Mandahl N, Johansson B, Mertens O, Persson B, Lasemark L, Wennerberg J, Jonsson N, Mitelman F: Cytogenetic analysis of 33 basal cell carcinomas. Cance Res 51: 954–957, 1991.
Kawasaki RS, Caldeira LF, Andre FS, Gasques JAL, Castilho WH, Bozola AR, Thome JA, Tajara EH: Multiple cytogenetic clones in a basal cell carcinoma. Cancer Genet Cytogenet 54:33–38, 1991.
Kawasaki-Oyama RS, Andre FS, Caldeira LF, Castilho WH, Gasques JAL, Bozola AR, Thome JA, Tajara EH: Cytogenetic findings in two basal cell carcinomas. Cancer Genet Cytogenet 73:152–156, 1994.
Konishi K, Yamanishi K, Ishizaki K, Yamada K, Saburo K, Yasuno H: Analysis of p53 mutations and loss of heterozygosity for loci on chromosome 9q in basal cell carcinoma. Cancer Lett 9:67–72, 1994.
Quinn AG, Sikkink S, Rees JL: Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss. Cancer Res 54:4756–4759, 1994.
Gailani MR, Bale SJ, Leffell DJ, DiGiovanna JJ, Peck GL, Poliak S, Drum MA, Pastakia B, McBride OW, Kase R, Greene M, Mulvihill JJ, Bale AE: Developmental defects in Gorlins syndrome related to a putative tumour suppressor gene on chromosome 9. Cell 69:111–117, 1992.
Goudie DR, Yuille, Leversha MA, Furlong RA, Carter NP, Lush MJ, Affara NA, Ferguson-Smith MA: Multiple self-healing squamous epitheliomata (ESS 1) mapped to chromosome 9q22-q31 in families with common ancestry. Nat Genet 3:165–169, 1993.
Yuspa SH, Diugosz AA: Cutaneous carcinogenesis: natural and experimental In: Goldsmith LA. (ed.), Physiology, Biochemistry and Molecular Biology of the Skin. New York: Oxford University, pp. 1365–1400, 1991.
Boyle P, Maisonneuve P, Dore JF: Epidemiology of malignant melanoma. Br Med Bull 51:523–547, 1995.
Lee JA: Trends in melanoma incidence and mortality. Clin Dermatol 10:913, 1992.
Rigel DS: Epidemiology and prognostic factors in malignant melanoma. Ann Pias Surg 28:7–8, 1992.
Gallagher RP, Mclean DI, Yang CP, Coldman AJ, Silver HK, Spinelli JJ, Beagrie M: Suntan, sunburn, and pigmentation factors and the frequency of acquired melanocytic nevi in children. Similarities to melanoma: the Vancouver mole study. Arch Dermatol 126:770–776, 1990.
Osterlink A, Tucker MA, Stone BJ, Jensen OM: The Danish case-control study of cutaneous malignant melanoma. II. Importance of UV light exposure. Int J Cancer 42:319–324, 1988.
Elwood JM: Melanoma and ultraviolet irradiation. Clin Dermatol 10: 41–50, 1992.
Cifone MA, Fidler IJ: Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms. Proc Natl Acad Sci USA 78:6949–6952, 1981.
Megidish T, Mazurek N: A mutant protein kinase C that can transform fibroblasts. Nature 342–807–811, 1989.
Fuchs J, Packet L: Ultraviolet irradition and the skin antioxidant system. Photodermatol Photoimmunol Photomed 7:90–92, 1990.
Rabiloud T, Asselilneau D, Miquel C, Calvayrac R, Darmon M, Vuillaume M: Deficiency in catalase activity correlates with the appearance of tumor phenotype in human keratinocytes. Int J Cancer 45:952–956, 1990.
Ronai AZ, Okini E, Weinstein IB: Ultraviolet light induces the expression of oncogenes in rat fibroblast and human keratinocytes. Oncogene 2:201–204, 1988.
Penn I: Ultraviolet light and skin cancer. Immunol Today 6:206–207, 1985.
Noonan FP, DeFablo EC: Ultraviolet B dose response curves for local and systemic immunosuppression are identical. Photochem Photobiol 52: 801–810, 1990.
Kripke MI: Ultraviolet radiation and tumor immunity. J Reticuloendothel Soc 22:217–222, 1977.
Crombie IK: Racial differences in melanoma incidence. Br J Cancer 40:185–193, 1979.
Clark WH Jr, Reimer RR, Greene M, Ainsworth AM, Mastrangelo MJ: Origin of familial malignant melanomas from heritable melanocytic lesions. Arch Dermatol 114:732, 1978.
Goldstein AM, Tucker MA: Genetic epidemiology of familial melanoma. Dermatol Clin 13:605–612, 1995.
Herlyn M: Molecular and Cellular Biology of Melanoma. Austin, TX: Landes, 1993.
Clark WH Jr, Elder DE, Guerry DIV, Epstein MN, Greene MH, Van Horn M. A study of tumor progression: the precursor lesions of superficial spreading and nodular melanoma. Hum Pathol 15:1147–1165, 1984.
Clark WH Jr, Tumor progression and the nature of cancer. Br J Cancer 64:631–644, 1991.
Elder DE, Clark WH Jr, Glenitsas R, Guerry DIV, Halpern AC: The early and intermediate precursor lesions of tumor progression in melanocytic systems: Common acquired nevi and atypical (dysplastic) nevi. Sem Diagnostic Pathol 1993.
National Institutes of Health: Precursors to malignant melanoma. National Institutes of Health, Oct. 24–26, 1983. Am J Dermatol 6:169–174, 1984.
Elder DE, Greene MH, Guerry DIV, Kraemer KH, Clark WH Jr: The dysplastic nevus syndrome: our definition. Am J Dermatol 4:455–460, 1982.
NIH Consensus Development Panel on Early Melanoma: Diagnosis and treatment of early melanoma. JAMA 268:1314–1319, 1992.
Balaban GB, Herlyn M, Clark WH Jr, Nowell PC: Karyotypic evolution in human malignant melanoma. Cancer Genet Cytogenet 19:113–122, 1986.
Richmond A, Fine R, Murray D, Lawson DH, Priest JH: Growth factor and cytogenetic abnormalities in cultured nevi and malignant melanomas. J Invest Dermatol 86:295–302, 1986.
Pedersen MI, Wang N: Chromosomal evolution in the progression and metastasis of human malignant melanoma. Cancer Genet Cytogenet 41:185–201, 1989.
Kath R, Rodeck U, Menssen HD, et al.: Tumor progression in the human melanocytic system. Anticancer Res 9:865–872, 1989.
Elder DE, Rodeck U, Thurin J, et al.: Antigenic profile of tumor progression stages in human melanocytic nevi and melanomas. Cancer Res 49: 5091–5096, 1989.
Breslow A: Thickness cross-sectional areas and depth of invasion in the prognosis of cutaneous melanoma. Ann Surg 172:902–907, 1970.
Clark WH, From L, Bernardino E A, Mihm MC: The histogenesis and biologic behavior of primary humn malignant melanomas of the skin. Cancer Res 29:705, 1969.
Clark WH, Elder DE, Guerry D, et al.: Model predicting survival in stage 1 melanoma based on tumor progression. J Natl Cancer Inst 81:1893, 1989.
Herzberg AJ, Kerns B J, Horowitz MJ, Scigler HF, Kinney RB: DNA ploidy of malignant melanoma determined by image cytometry of fresh frozen and paraffin-embedded tissue. J Cutan Pathol 18:440–48, 1991.
Fountain JW, Bales SJ, Housman DE, Dracopoli NC: Genetics of melanoma. In: Franks LM (ed.), Cancer Survey: Advances and Prospects in Clinical, Epidemiological and Laboratory Oncology. London: Oxford University, Press; pp. 645–671, 1990.
Bales SJ, Dracopoli NC, Tucker MA, et al.: Mapping the gene for hereditary cutaneous malignant melanoma-dysplastic nevus to chromosome 1p. N Engl J Med 320:1367–1372, 1989.
Parmiter AH, Nowell PC: The cytogenetics of human malignant melanoma and premalignant lesons. In: Nathanson L. (ed.), Malignant melanoma: Biology, Diagnsois, and Therapy. Boston, MA: Kluwer Academic, pp. 47–61, 1988.
Dracopoli NC, Harnett P, Bale SJ, et al.: Loss of alleles from the distal short arm of chromosome 1 occurs late in melanoma tumor progression. Proc Natl Acad Sci USA 86:4614–4618, 1989.
Finger LR, Kagan J, Christopher G, et al.: Involvement of the TCL5 gene on human chromosome 1 in T-cell leukemia and melanoma. Proc Natl Acad Sci USA 86:5039–5043, 1989.
Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ: Localization of the expressed human p58 protein kinase chnDmosomal gene to chromosome lp36 and a highly related sequence to chromosome 1 5. Genomics 11: 621–629, 1991.
Millikin D, Meese E, Vogelstein B, Witkowski C, Trent J: Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma. Cancer Res 51:5449–5453, 1991.
Trent JM, Meyskens FL, Salmon SE, et al.: Relation of cytogenetic abnormalities and clinical outcome in metastatic melanoma. N Engl J Med 322:1508–1511, 1990.
Linnenbach AJ, Huebner K, Reddy EP, et al.: Structural alteration in the MYB protooncogene and deletion within the gene encoding alpha-type protein kinase C in human melanoma cell lines. Proc Natl Acad Sci USA 85:74–78, 1988.
Meese E, Meltzer PS, Witkowski CM, Trent JM: Molecular mapping of the oncogene myb and rearrangements in malignant melanoma. Genes Chromosome Cancer 1:88–94, 1989.
Koprowski H, Herlyn M, Balaban G, Parmiter A, Ross A, Nowell P: Expression of the receptor for epidermal growth factor correlates with increased dosage of chromosome 7 in malignant melanoma. Somat Cell Mol Genet 11:297–302, 1985.
Wittbrodt J, Adam D, Malitscheck B, Maueler W, Raulf F, Telling A, Robertson SM, Schartl M: Novel putative receptor tyrosine kinase encoded by the melanoma-inducing Tu locus in Xiphophorus. Nature 341:414–421, 1989.
Balaban G, Herlyn M, Guerry DIV, Bartolo R, Koprowski H, Clark WH Jr, Nowell PC: Cytogenetics of human malignant melanoma and premalignant lesions. Cancer Genet Cytogenet 11:429–439, 1984.
Collard JG, van de Poll M, Scheffer A, et al.: Localization of genes involved in invasion and metastasis on human chromosome 7. Cancer Res 47:6666–6670, 1987.
Fountain JW, Karayiorgou M, Ernstoff MS, et al.: Homozygous deletions within human chromosome band 9p21 in melanoma. Proc Natl Acad Sci USA 89:10, 557–10, 561, 1992.
Parmiter AH, Balaban G, Clark WH Jr, Nowell PC: Possible involvement of the chromosome region 10q24-q26 in early stages of melanocytic neoplasia. Cancer Genet Cytogenet 30:313–317, 1988.
Dracopoli NC, Houghton AN, Old LJ: Loss of polymorphic restriction fragments inmalignant melanoma: implications for tumor heterogeneity. Proc Natl Acad Sci USA 82:1470–1474, 1985.
Albino A, Fountain JW: Molecular genetics of human malignant melanoma. Cancer Treatment Res 65:201–255, 1993.
Yamanishi DT, Buckmeier JA, Meyskens FL Jr: Expression of c-jun, jun-B, and c-fos protooncogenes in human primary melanocytes and metastatic melanoma. J Invest Dermatol 97:349–353, 1991.
Halaban R, Moellmann G: Proliferation and malignant transformation of melanocytes. Crit Rev Oncog 2:247–258, 1991.
Chabot B, Stephenson DA, Chapman VM, Nesmer P, Bernstein A: The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335:88, 89, 1988.
Geissler EN, Ryan MA, Housman DE: The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55; 185–192, 1988.
Toker C: Trabecular carcinoma of the skin. Arch Dermatol 105: 107–110, 1972.
Andrew KE, Silvers DN, Lattes R: Merkel cell carcinoma. In: Friedman RJ, Rigel DS, Kopf AW, et al. (eds.). Cancer of the Skin. New York: Saunders, pp. 228–294, 1991.
Ratner D, Nelson BR, Brown MD, Hohnson TM: Merkel cell carcinoma. J Am Acad Dermatol 29:143–156, 1993.
Mercer D, Brander P, Liddell K: Merkel cell carcinoma: the clinical course. Ann Plast Surg 25:136–141, 1990.
Johansson L, Tenvall J, Akeman M: Immunohistochemical examination of 25 cases of Merkel cell carcinoma: a comparison with small cell carcinoma of the lung and oesophagus, and review of the literature. Acta Pathol Microbiol Immunol Scand 98:741–752, 1990.
Kusyk CJ, Romsdahl MM: Cytogenetic studies of a Merkel cell carcinoma. Cancer Genet Cytogenet 20:311–316, 1986.
Smadja N, de Gramont A, Gonzalez-Canali G, Louvet EW, Krulik M: Cytogenetic study of a bone marrow metastatic Merkel cell carcinoma. Cancer Genet Cytogenet 51:85–87, 1991.
Sandbrick F, Muler L, Fiebig HH, Kovacs F: Short communication: Deletion 7q, trisomy 6 and 11 in a case of Merkel cell carcinoma. Cancer Genet Cytogenet 33:305–309, 1988.
Harnett PR, Kearsley JH, Hay ward NK, et al.: Loss of allelic heterozygosity on distal chromosome 1p in Merkel cell carcinoma: a marker of neural crest origin? Cancer Genet Cytogenet 54:109–113, 1991.
Osella P, Carlson A, Wyandt H, Milunsky A: Cytogenetic studies of eight squamous cell carcinomas of the head and neck: deletion of 7q, a possible primary chromosomal event. Cancer Genet Cytogenet 59:73–78, 1992.
Zaslav AL, Stamberg J, Steinberg BM, Lin YJ, Abramson A: Cyotgenetic analysis of head and neck carcinomas. Cancer Genet Cytogenet 56: 181–187, 1991.
Pejovic T, Heim S, Orndal C, Jin Y, Mandahl N, Willen H, Mitelman F: Simple numerical chromosome aberrations in well-differentiated malignant epithelial tumors. Cancer Genet Cytogenet 49:95–101, 1990.
Owens W, Fild JK, Howard PJ, Stell PM: Multiple cytogenetic aberrations in squamous cell carcinomas of the head and neck. Oral Oncol Eur J Cancer 28B:1721, 1992.
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Worsham, M.J., Nathanson, S.D., Lee, M., Wolman, S.R. (1997). Cytogenetic Biomarkers in Skin Cancer. In: Wolman, S.R., Sell, S. (eds) Human Cytogenetic Cancer Markers. Contemporary Biomedicine, vol 13. Humana Press. https://doi.org/10.1007/978-1-4612-3952-9_12
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