Prostate Cancer

  • Arthur R. Brothman
  • Briana J. Williams
Part of the Contemporary Biomedicine book series (CB, volume 13)


As the leading malignancy of males in Western countries, prostate cancer has become a major research focus, yet only recently have techniques become available for the accurate study of this complex tumor. Clinically, prostate tumors follow widely varying courses of progression, with a subset of tumors showing little or no advancement and rarely causing death, in contrast to aggressive tumors that metastasize to bone, lymph nodes or other sites and kill the patient. There is currently no biological marker that can distinguish the indolent from the aggressive form of this disease. Current methods for prostate cancer detection include digital rectal examination, ultrasonic analysis, and assay for serum levels of the prostatic specific antigen (PSA). Although PSA screening, combined with digital rectal examination is the most sensitive test to date, it fails to detect all tumors, gives false positive results, and cannot distinguish indolent from aggressive tumors. Treatment of early-stage prostate cancer in the United States often involves removal of the prostate gland, especially in otherwise healthy men, but the surgery is often complicated by significant side effects, including incontinence and impotence which negatively affect the quality of postsurgical life.


Comparative Genomic Hybridization Prostate Tumor Human Prostate Cancer Allelic Imbalance Androgen Receptor Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Humana Press Inc. 1997

Authors and Affiliations

  • Arthur R. Brothman
  • Briana J. Williams

There are no affiliations available

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